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Outcomes and treatment of acute hepatitis C virus infection in a United States population

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Outcomes and treatment of acute hepatitis C virus infection in a United States population. / Corey, Kathleen E; Ross, Andrew S; Wurcel, Alysse; Schulze Zur Wiesch, Julian; Kim, Arthur Y; Lauer, Georg M; Chung, Raymond T.

In: CLIN GASTROENTEROL H, Vol. 4, No. 10, 10.2006, p. 1278-82.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Corey, KE, Ross, AS, Wurcel, A, Schulze Zur Wiesch, J, Kim, AY, Lauer, GM & Chung, RT 2006, 'Outcomes and treatment of acute hepatitis C virus infection in a United States population', CLIN GASTROENTEROL H, vol. 4, no. 10, pp. 1278-82. https://doi.org/10.1016/j.cgh.2006.06.026

APA

Corey, K. E., Ross, A. S., Wurcel, A., Schulze Zur Wiesch, J., Kim, A. Y., Lauer, G. M., & Chung, R. T. (2006). Outcomes and treatment of acute hepatitis C virus infection in a United States population. CLIN GASTROENTEROL H, 4(10), 1278-82. https://doi.org/10.1016/j.cgh.2006.06.026

Vancouver

Corey KE, Ross AS, Wurcel A, Schulze Zur Wiesch J, Kim AY, Lauer GM et al. Outcomes and treatment of acute hepatitis C virus infection in a United States population. CLIN GASTROENTEROL H. 2006 Oct;4(10):1278-82. https://doi.org/10.1016/j.cgh.2006.06.026

Bibtex

@article{4da585b18cbf4a039e678562d71a253a,
title = "Outcomes and treatment of acute hepatitis C virus infection in a United States population",
abstract = "BACKGROUND & AIMS: Acute hepatitis C infection progresses to chronic infection in up to 80% of infected persons. Reports from Europe indicate that early treatment of acute hepatitis C infection produces sustained virologic response rates as high as 80%-98%. However, the outcome of acute hepatitis C infection in United States cohorts is not well-characterized.METHODS: We describe the clinical course of 28 episodes of acute hepatitis C infection in 24 persons at our institution.RESULTS: Of the 28 infections, 7 episodes resolved spontaneously. Of the remaining 21 episodes, 16 were treated, and 5 did not receive treatment. Of the 16 treated episodes, 4 received interferon and ribavirin, 11 received pegylated interferon and ribavirin, and 1 was treated initially with interferon monotherapy followed by pegylated interferon monotherapy. Among those episodes treated with interferon, 3 of 4 experienced sustained virologic response. Among those episodes treated with pegylated interferon, all 12 achieved SVR. In total, 15 of 16 treated patients (94%) experienced SVR. In all, 18 of the 24 patients (75%) experienced spontaneous or treatment-induced sustained virologic clearance.CONCLUSIONS: Our experience with treated and untreated acute HCV infection is comparable to that observed in Europe. Patients treated with antiviral therapy had an excellent response. Randomized trials to investigate immediate versus delayed treatment of acute hepatitis C infection are warranted. In view of these strongly positive outcomes, increased vigilance for acute hepatitis C becomes essential.",
keywords = "Acute Disease, Adolescent, Adult, Antiviral Agents/therapeutic use, DNA, Viral/analysis, Female, Follow-Up Studies, Genotype, Hepacivirus/genetics, Hepatitis C/drug therapy, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Treatment Outcome, United States/epidemiology, Viral Load",
author = "Corey, {Kathleen E} and Ross, {Andrew S} and Alysse Wurcel and {Schulze Zur Wiesch}, Julian and Kim, {Arthur Y} and Lauer, {Georg M} and Chung, {Raymond T}",
year = "2006",
month = oct,
doi = "10.1016/j.cgh.2006.06.026",
language = "English",
volume = "4",
pages = "1278--82",
journal = "CLIN GASTROENTEROL H",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "10",

}

RIS

TY - JOUR

T1 - Outcomes and treatment of acute hepatitis C virus infection in a United States population

AU - Corey, Kathleen E

AU - Ross, Andrew S

AU - Wurcel, Alysse

AU - Schulze Zur Wiesch, Julian

AU - Kim, Arthur Y

AU - Lauer, Georg M

AU - Chung, Raymond T

PY - 2006/10

Y1 - 2006/10

N2 - BACKGROUND & AIMS: Acute hepatitis C infection progresses to chronic infection in up to 80% of infected persons. Reports from Europe indicate that early treatment of acute hepatitis C infection produces sustained virologic response rates as high as 80%-98%. However, the outcome of acute hepatitis C infection in United States cohorts is not well-characterized.METHODS: We describe the clinical course of 28 episodes of acute hepatitis C infection in 24 persons at our institution.RESULTS: Of the 28 infections, 7 episodes resolved spontaneously. Of the remaining 21 episodes, 16 were treated, and 5 did not receive treatment. Of the 16 treated episodes, 4 received interferon and ribavirin, 11 received pegylated interferon and ribavirin, and 1 was treated initially with interferon monotherapy followed by pegylated interferon monotherapy. Among those episodes treated with interferon, 3 of 4 experienced sustained virologic response. Among those episodes treated with pegylated interferon, all 12 achieved SVR. In total, 15 of 16 treated patients (94%) experienced SVR. In all, 18 of the 24 patients (75%) experienced spontaneous or treatment-induced sustained virologic clearance.CONCLUSIONS: Our experience with treated and untreated acute HCV infection is comparable to that observed in Europe. Patients treated with antiviral therapy had an excellent response. Randomized trials to investigate immediate versus delayed treatment of acute hepatitis C infection are warranted. In view of these strongly positive outcomes, increased vigilance for acute hepatitis C becomes essential.

AB - BACKGROUND & AIMS: Acute hepatitis C infection progresses to chronic infection in up to 80% of infected persons. Reports from Europe indicate that early treatment of acute hepatitis C infection produces sustained virologic response rates as high as 80%-98%. However, the outcome of acute hepatitis C infection in United States cohorts is not well-characterized.METHODS: We describe the clinical course of 28 episodes of acute hepatitis C infection in 24 persons at our institution.RESULTS: Of the 28 infections, 7 episodes resolved spontaneously. Of the remaining 21 episodes, 16 were treated, and 5 did not receive treatment. Of the 16 treated episodes, 4 received interferon and ribavirin, 11 received pegylated interferon and ribavirin, and 1 was treated initially with interferon monotherapy followed by pegylated interferon monotherapy. Among those episodes treated with interferon, 3 of 4 experienced sustained virologic response. Among those episodes treated with pegylated interferon, all 12 achieved SVR. In total, 15 of 16 treated patients (94%) experienced SVR. In all, 18 of the 24 patients (75%) experienced spontaneous or treatment-induced sustained virologic clearance.CONCLUSIONS: Our experience with treated and untreated acute HCV infection is comparable to that observed in Europe. Patients treated with antiviral therapy had an excellent response. Randomized trials to investigate immediate versus delayed treatment of acute hepatitis C infection are warranted. In view of these strongly positive outcomes, increased vigilance for acute hepatitis C becomes essential.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Antiviral Agents/therapeutic use

KW - DNA, Viral/analysis

KW - Female

KW - Follow-Up Studies

KW - Genotype

KW - Hepacivirus/genetics

KW - Hepatitis C/drug therapy

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Treatment Outcome

KW - United States/epidemiology

KW - Viral Load

U2 - 10.1016/j.cgh.2006.06.026

DO - 10.1016/j.cgh.2006.06.026

M3 - SCORING: Journal article

C2 - 16931171

VL - 4

SP - 1278

EP - 1282

JO - CLIN GASTROENTEROL H

JF - CLIN GASTROENTEROL H

SN - 1542-3565

IS - 10

ER -