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Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients

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Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients. / Broessner, Gregor; Hasslacher, Julia; Beer, Ronny; Lackner, Peter; Lehner, Georg Franz; Harler, Ulrich; Schiefecker, Alois; Helbok, Raimund; Pfausler, Bettina; Hammerer-Lercher, Angelika; Joannidis, Michael.

In: RESUSCITATION, Vol. 89, 04.2015, p. 75-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Broessner, G, Hasslacher, J, Beer, R, Lackner, P, Lehner, GF, Harler, U, Schiefecker, A, Helbok, R, Pfausler, B, Hammerer-Lercher, A & Joannidis, M 2015, 'Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients', RESUSCITATION, vol. 89, pp. 75-80. https://doi.org/10.1016/j.resuscitation.2015.01.013

APA

Broessner, G., Hasslacher, J., Beer, R., Lackner, P., Lehner, G. F., Harler, U., Schiefecker, A., Helbok, R., Pfausler, B., Hammerer-Lercher, A., & Joannidis, M. (2015). Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients. RESUSCITATION, 89, 75-80. https://doi.org/10.1016/j.resuscitation.2015.01.013

Vancouver

Broessner G, Hasslacher J, Beer R, Lackner P, Lehner GF, Harler U et al. Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients. RESUSCITATION. 2015 Apr;89:75-80. https://doi.org/10.1016/j.resuscitation.2015.01.013

Bibtex

@article{1c158d4b2f2d43f294143aaed918d633,
title = "Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients",
abstract = "OBJECTIVE: To evaluate the prognostic potential of serum C-terminal provasopressin (CT-proAVP or Copeptin) and midregional pro-A-type natriuretic peptide (MR-proANP) to predict neurological outcome following resuscitation from cardiac arrest.METHODS: In this prospective observational study, we employed novel ultra sensitive immunoassay technology to examine serial serum samples from 134 cardiac arrest patients. Patients were either allocated to mild therapeutic hypothermia using an endovascular device or normothermia. Serial blood samples were obtained from resuscitated cardiac arrest survivors during their first 7 days in an intensive care unit, and serum Copeptin and MR-proANP were measured. Cerebral function assessments were made using cerebral performance categorization (CPC) at discharge from hospital. Copeptin and MR-proANP data were analyzed using dichotomized CPC scores (1-2 versus 3-5).RESULTS: Sixty-nine patients (51%) had a poor outcome (CPC 3-5) at hospital discharge. MR-proANP and Copeptin peaked on day 1 (i.e. 0-24h) with the medians being 249.3pmol/L and 77.2pmol/L, respectively. In the first 48h maximum levels of MR-proANP and Copeptin showed an AUC in the ROC of 0.743 (95% CI: 0.658-0.828) and 0.677 (95% CI: 0.583-0.771). Binary logistic regression revealed MR-proANP and Copeptin within 48h after ROSC being significantly associated with functional outcome (p<0.05). Copeptin within 48h was also associated with outcome in the hypothermia group (p<0.05).CONCLUSION: Systemic levels of MR-proANP and Copeptin peak early in cardiac arrest patients in the 48h post-resuscitation period. MR-proANP and Copeptin were highly predictive for poor outcome in comatose resuscitated patients.",
keywords = "Adult, Aged, Atrial Natriuretic Factor, Biomarkers, Female, Glycopeptides, Heart Arrest, Humans, Hypothermia, Induced, Male, Middle Aged, Outcome Assessment (Health Care), Predictive Value of Tests, Prognosis, Prospective Studies, Resuscitation, Journal Article, Observational Study, Research Support, Non-U.S. Gov't",
author = "Gregor Broessner and Julia Hasslacher and Ronny Beer and Peter Lackner and Lehner, {Georg Franz} and Ulrich Harler and Alois Schiefecker and Raimund Helbok and Bettina Pfausler and Angelika Hammerer-Lercher and Michael Joannidis",
note = "Copyright {\textcopyright} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = apr,
doi = "10.1016/j.resuscitation.2015.01.013",
language = "English",
volume = "89",
pages = "75--80",
journal = "RESUSCITATION",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Outcome prediction and temperature dependency of MR-proANP and Copeptin in comatose resuscitated patients

AU - Broessner, Gregor

AU - Hasslacher, Julia

AU - Beer, Ronny

AU - Lackner, Peter

AU - Lehner, Georg Franz

AU - Harler, Ulrich

AU - Schiefecker, Alois

AU - Helbok, Raimund

AU - Pfausler, Bettina

AU - Hammerer-Lercher, Angelika

AU - Joannidis, Michael

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/4

Y1 - 2015/4

N2 - OBJECTIVE: To evaluate the prognostic potential of serum C-terminal provasopressin (CT-proAVP or Copeptin) and midregional pro-A-type natriuretic peptide (MR-proANP) to predict neurological outcome following resuscitation from cardiac arrest.METHODS: In this prospective observational study, we employed novel ultra sensitive immunoassay technology to examine serial serum samples from 134 cardiac arrest patients. Patients were either allocated to mild therapeutic hypothermia using an endovascular device or normothermia. Serial blood samples were obtained from resuscitated cardiac arrest survivors during their first 7 days in an intensive care unit, and serum Copeptin and MR-proANP were measured. Cerebral function assessments were made using cerebral performance categorization (CPC) at discharge from hospital. Copeptin and MR-proANP data were analyzed using dichotomized CPC scores (1-2 versus 3-5).RESULTS: Sixty-nine patients (51%) had a poor outcome (CPC 3-5) at hospital discharge. MR-proANP and Copeptin peaked on day 1 (i.e. 0-24h) with the medians being 249.3pmol/L and 77.2pmol/L, respectively. In the first 48h maximum levels of MR-proANP and Copeptin showed an AUC in the ROC of 0.743 (95% CI: 0.658-0.828) and 0.677 (95% CI: 0.583-0.771). Binary logistic regression revealed MR-proANP and Copeptin within 48h after ROSC being significantly associated with functional outcome (p<0.05). Copeptin within 48h was also associated with outcome in the hypothermia group (p<0.05).CONCLUSION: Systemic levels of MR-proANP and Copeptin peak early in cardiac arrest patients in the 48h post-resuscitation period. MR-proANP and Copeptin were highly predictive for poor outcome in comatose resuscitated patients.

AB - OBJECTIVE: To evaluate the prognostic potential of serum C-terminal provasopressin (CT-proAVP or Copeptin) and midregional pro-A-type natriuretic peptide (MR-proANP) to predict neurological outcome following resuscitation from cardiac arrest.METHODS: In this prospective observational study, we employed novel ultra sensitive immunoassay technology to examine serial serum samples from 134 cardiac arrest patients. Patients were either allocated to mild therapeutic hypothermia using an endovascular device or normothermia. Serial blood samples were obtained from resuscitated cardiac arrest survivors during their first 7 days in an intensive care unit, and serum Copeptin and MR-proANP were measured. Cerebral function assessments were made using cerebral performance categorization (CPC) at discharge from hospital. Copeptin and MR-proANP data were analyzed using dichotomized CPC scores (1-2 versus 3-5).RESULTS: Sixty-nine patients (51%) had a poor outcome (CPC 3-5) at hospital discharge. MR-proANP and Copeptin peaked on day 1 (i.e. 0-24h) with the medians being 249.3pmol/L and 77.2pmol/L, respectively. In the first 48h maximum levels of MR-proANP and Copeptin showed an AUC in the ROC of 0.743 (95% CI: 0.658-0.828) and 0.677 (95% CI: 0.583-0.771). Binary logistic regression revealed MR-proANP and Copeptin within 48h after ROSC being significantly associated with functional outcome (p<0.05). Copeptin within 48h was also associated with outcome in the hypothermia group (p<0.05).CONCLUSION: Systemic levels of MR-proANP and Copeptin peak early in cardiac arrest patients in the 48h post-resuscitation period. MR-proANP and Copeptin were highly predictive for poor outcome in comatose resuscitated patients.

KW - Adult

KW - Aged

KW - Atrial Natriuretic Factor

KW - Biomarkers

KW - Female

KW - Glycopeptides

KW - Heart Arrest

KW - Humans

KW - Hypothermia, Induced

KW - Male

KW - Middle Aged

KW - Outcome Assessment (Health Care)

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Resuscitation

KW - Journal Article

KW - Observational Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.resuscitation.2015.01.013

DO - 10.1016/j.resuscitation.2015.01.013

M3 - SCORING: Journal article

C2 - 25619444

VL - 89

SP - 75

EP - 80

JO - RESUSCITATION

JF - RESUSCITATION

SN - 0300-9572

ER -