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Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation.

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Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation. / Kirchner, Gabriele I; Rifai, Kinan; Cantz, Tobias; Nashan, Björn; Terkamp, Christoph; Becker, Thomas; Strassburg, Christian; Barg-Hock, Hannelore; Wagner, Siegfried; Lück, Rainer; Klempnauer, Juergen; Manns, Michael P.

In: LIVER TRANSPLANT, Vol. 12, No. 8, 8, 2006, p. 1268-1277.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kirchner, GI, Rifai, K, Cantz, T, Nashan, B, Terkamp, C, Becker, T, Strassburg, C, Barg-Hock, H, Wagner, S, Lück, R, Klempnauer, J & Manns, MP 2006, 'Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation.', LIVER TRANSPLANT, vol. 12, no. 8, 8, pp. 1268-1277. <http://www.ncbi.nlm.nih.gov/pubmed/16741930?dopt=Citation>

APA

Kirchner, G. I., Rifai, K., Cantz, T., Nashan, B., Terkamp, C., Becker, T., Strassburg, C., Barg-Hock, H., Wagner, S., Lück, R., Klempnauer, J., & Manns, M. P. (2006). Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation. LIVER TRANSPLANT, 12(8), 1268-1277. [8]. http://www.ncbi.nlm.nih.gov/pubmed/16741930?dopt=Citation

Vancouver

Kirchner GI, Rifai K, Cantz T, Nashan B, Terkamp C, Becker T et al. Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation. LIVER TRANSPLANT. 2006;12(8):1268-1277. 8.

Bibtex

@article{44aae0432ad64cfb9928104c3fe3b4a6,
title = "Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation.",
abstract = "In advanced stages of polycystic liver disease, often associated with polycystic kidney disease, a curative therapy is liver or combined liver-kidney transplantation. However, little is known about long-term outcome and quality of life. Between 1990 and 2003, 36 patients (32 female, 4 male) with polycystic liver or combined liver-kidney disease underwent liver (n = 21) or liver-kidney (n = 15) transplantation at our center. Main indications for liver transplantation were cachexia, muscle atrophy, loss of weight, recurrent cyst infections, portal hypertension, and ascites. Apart from clinical parameters, 2 anonymous questionnaires (standard short form 36 and self-designed) addressing quality of life and social status were evaluated. Five patients (14 %) died due to sepsis or myocardial infarction with pneumonia, all within 61 days after transplantation. The follow-up time of the remaining 31 patients ranged from 5 to 156 months, with a mean of 62 months. Of the 23 (74%) answered the questionnaires, 91% of patients felt {"}much better{"} or {"}better,{"} only 9% felt {"}worse{"} than before, and 52% of patients participated in sports regularly. Fatigue, physical fitness, loss of appetite, and vomiting improved significantly after transplantation. Physical attractiveness and interest in sex increased as well. Professional occupation did not change for 71% of patients. Family situation before and after transplantation changed in 1 case only. Finally, 78% of patients said they would opt for transplantation again, while 17% were undecided; 1 patient would not repeat transplantation. In conclusion, patients with advanced polycystic liver or polycystic liver-kidney disease have an excellent survival rate and an improved quality of life after liver or combined liver-kidney transplantation.",
author = "Kirchner, {Gabriele I} and Kinan Rifai and Tobias Cantz and Bj{\"o}rn Nashan and Christoph Terkamp and Thomas Becker and Christian Strassburg and Hannelore Barg-Hock and Siegfried Wagner and Rainer L{\"u}ck and Juergen Klempnauer and Manns, {Michael P}",
year = "2006",
language = "Deutsch",
volume = "12",
pages = "1268--1277",
journal = "LIVER TRANSPLANT",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation.

AU - Kirchner, Gabriele I

AU - Rifai, Kinan

AU - Cantz, Tobias

AU - Nashan, Björn

AU - Terkamp, Christoph

AU - Becker, Thomas

AU - Strassburg, Christian

AU - Barg-Hock, Hannelore

AU - Wagner, Siegfried

AU - Lück, Rainer

AU - Klempnauer, Juergen

AU - Manns, Michael P

PY - 2006

Y1 - 2006

N2 - In advanced stages of polycystic liver disease, often associated with polycystic kidney disease, a curative therapy is liver or combined liver-kidney transplantation. However, little is known about long-term outcome and quality of life. Between 1990 and 2003, 36 patients (32 female, 4 male) with polycystic liver or combined liver-kidney disease underwent liver (n = 21) or liver-kidney (n = 15) transplantation at our center. Main indications for liver transplantation were cachexia, muscle atrophy, loss of weight, recurrent cyst infections, portal hypertension, and ascites. Apart from clinical parameters, 2 anonymous questionnaires (standard short form 36 and self-designed) addressing quality of life and social status were evaluated. Five patients (14 %) died due to sepsis or myocardial infarction with pneumonia, all within 61 days after transplantation. The follow-up time of the remaining 31 patients ranged from 5 to 156 months, with a mean of 62 months. Of the 23 (74%) answered the questionnaires, 91% of patients felt "much better" or "better," only 9% felt "worse" than before, and 52% of patients participated in sports regularly. Fatigue, physical fitness, loss of appetite, and vomiting improved significantly after transplantation. Physical attractiveness and interest in sex increased as well. Professional occupation did not change for 71% of patients. Family situation before and after transplantation changed in 1 case only. Finally, 78% of patients said they would opt for transplantation again, while 17% were undecided; 1 patient would not repeat transplantation. In conclusion, patients with advanced polycystic liver or polycystic liver-kidney disease have an excellent survival rate and an improved quality of life after liver or combined liver-kidney transplantation.

AB - In advanced stages of polycystic liver disease, often associated with polycystic kidney disease, a curative therapy is liver or combined liver-kidney transplantation. However, little is known about long-term outcome and quality of life. Between 1990 and 2003, 36 patients (32 female, 4 male) with polycystic liver or combined liver-kidney disease underwent liver (n = 21) or liver-kidney (n = 15) transplantation at our center. Main indications for liver transplantation were cachexia, muscle atrophy, loss of weight, recurrent cyst infections, portal hypertension, and ascites. Apart from clinical parameters, 2 anonymous questionnaires (standard short form 36 and self-designed) addressing quality of life and social status were evaluated. Five patients (14 %) died due to sepsis or myocardial infarction with pneumonia, all within 61 days after transplantation. The follow-up time of the remaining 31 patients ranged from 5 to 156 months, with a mean of 62 months. Of the 23 (74%) answered the questionnaires, 91% of patients felt "much better" or "better," only 9% felt "worse" than before, and 52% of patients participated in sports regularly. Fatigue, physical fitness, loss of appetite, and vomiting improved significantly after transplantation. Physical attractiveness and interest in sex increased as well. Professional occupation did not change for 71% of patients. Family situation before and after transplantation changed in 1 case only. Finally, 78% of patients said they would opt for transplantation again, while 17% were undecided; 1 patient would not repeat transplantation. In conclusion, patients with advanced polycystic liver or polycystic liver-kidney disease have an excellent survival rate and an improved quality of life after liver or combined liver-kidney transplantation.

M3 - SCORING: Zeitschriftenaufsatz

VL - 12

SP - 1268

EP - 1277

JO - LIVER TRANSPLANT

JF - LIVER TRANSPLANT

SN - 1527-6465

IS - 8

M1 - 8

ER -