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Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit

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Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit. / Heil, J; Gondos, A; Rauch, G; Marmé, F; Rom, J; Golatta, M; Junkermann, H; Sinn, P; Aulmann, S; Debus, J; Hof, H; Schütz, F; Brenner, H; Sohn, C; Schneeweiss, A.

In: BREAST, Vol. 21, No. 3, 06.2012, p. 303-308.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heil, J, Gondos, A, Rauch, G, Marmé, F, Rom, J, Golatta, M, Junkermann, H, Sinn, P, Aulmann, S, Debus, J, Hof, H, Schütz, F, Brenner, H, Sohn, C & Schneeweiss, A 2012, 'Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit', BREAST, vol. 21, no. 3, pp. 303-308. https://doi.org/10.1016/j.breast.2012.01.009

APA

Heil, J., Gondos, A., Rauch, G., Marmé, F., Rom, J., Golatta, M., Junkermann, H., Sinn, P., Aulmann, S., Debus, J., Hof, H., Schütz, F., Brenner, H., Sohn, C., & Schneeweiss, A. (2012). Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit. BREAST, 21(3), 303-308. https://doi.org/10.1016/j.breast.2012.01.009

Vancouver

Heil J, Gondos A, Rauch G, Marmé F, Rom J, Golatta M et al. Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit. BREAST. 2012 Jun;21(3):303-308. https://doi.org/10.1016/j.breast.2012.01.009

Bibtex

@article{dbe51c3785e140788603e2a4d53f778e,
title = "Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit",
abstract = "INTRODUCTION: Evaluation of oncological outcome and prognostic factors of patients with primary breast cancer treated at a certified academic breast unit.PATIENTS AND METHODS: We prospectively collected data of 3338 patients, diagnosed with primary breast cancer between 01.01.2003 and 31.12.2010 and treated at the Breast Unit Heidelberg, Germany, in order to analyze outcome in clinical practice. We evaluated local control rate (LCR), disease-free survival (DFS), distant disease-free survival (DDFS), observed overall survival (OS) and age-adjusted relative overall survival (ROS). In addition, the impact of known prognostic factors on these outcome variables was examined in univariate and multivariate analyses.RESULTS: Of all patients, 368 (11.0%) had carcinoma in situ (CIS) and 197 (5.9%) had bilateral cancers. For the 2970 patients with invasive cancer, of which 49 patients (1.7%) had metastastic disease at time of diagnosis, DFS, LCR, DDFS, OS and ROS at 5 years were 79.8%, 84.7%, 81.2%, 86.3%, and 89.8%, respectively. In multivariate analysis age, pT category, nodal status, hormone receptor status and grading were identified as independent prognostic factors for OS.CONCLUSION: Compared with recent population-based reports from Germany, more favourable patient characteristics and nominally higher survival was found among this large cohort of patients with primary breast cancer treated at a single certified breast unit.",
keywords = "Academic Medical Centers, Adult, Age Factors, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Carcinoma, Chemotherapy, Adjuvant, Combined Modality Therapy, Disease-Free Survival, Female, Germany, Humans, Middle Aged, Prognosis, Prospective Studies, Radiotherapy, Adjuvant, Survival Rate, Treatment Outcome, Women's Health, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "J Heil and A Gondos and G Rauch and F Marm{\'e} and J Rom and M Golatta and H Junkermann and P Sinn and S Aulmann and J Debus and H Hof and F Sch{\"u}tz and H Brenner and C Sohn and A Schneeweiss",
note = "Copyright {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",
year = "2012",
month = jun,
doi = "10.1016/j.breast.2012.01.009",
language = "English",
volume = "21",
pages = "303--308",
journal = "BREAST",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "3",

}

RIS

TY - JOUR

T1 - Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit

AU - Heil, J

AU - Gondos, A

AU - Rauch, G

AU - Marmé, F

AU - Rom, J

AU - Golatta, M

AU - Junkermann, H

AU - Sinn, P

AU - Aulmann, S

AU - Debus, J

AU - Hof, H

AU - Schütz, F

AU - Brenner, H

AU - Sohn, C

AU - Schneeweiss, A

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2012/6

Y1 - 2012/6

N2 - INTRODUCTION: Evaluation of oncological outcome and prognostic factors of patients with primary breast cancer treated at a certified academic breast unit.PATIENTS AND METHODS: We prospectively collected data of 3338 patients, diagnosed with primary breast cancer between 01.01.2003 and 31.12.2010 and treated at the Breast Unit Heidelberg, Germany, in order to analyze outcome in clinical practice. We evaluated local control rate (LCR), disease-free survival (DFS), distant disease-free survival (DDFS), observed overall survival (OS) and age-adjusted relative overall survival (ROS). In addition, the impact of known prognostic factors on these outcome variables was examined in univariate and multivariate analyses.RESULTS: Of all patients, 368 (11.0%) had carcinoma in situ (CIS) and 197 (5.9%) had bilateral cancers. For the 2970 patients with invasive cancer, of which 49 patients (1.7%) had metastastic disease at time of diagnosis, DFS, LCR, DDFS, OS and ROS at 5 years were 79.8%, 84.7%, 81.2%, 86.3%, and 89.8%, respectively. In multivariate analysis age, pT category, nodal status, hormone receptor status and grading were identified as independent prognostic factors for OS.CONCLUSION: Compared with recent population-based reports from Germany, more favourable patient characteristics and nominally higher survival was found among this large cohort of patients with primary breast cancer treated at a single certified breast unit.

AB - INTRODUCTION: Evaluation of oncological outcome and prognostic factors of patients with primary breast cancer treated at a certified academic breast unit.PATIENTS AND METHODS: We prospectively collected data of 3338 patients, diagnosed with primary breast cancer between 01.01.2003 and 31.12.2010 and treated at the Breast Unit Heidelberg, Germany, in order to analyze outcome in clinical practice. We evaluated local control rate (LCR), disease-free survival (DFS), distant disease-free survival (DDFS), observed overall survival (OS) and age-adjusted relative overall survival (ROS). In addition, the impact of known prognostic factors on these outcome variables was examined in univariate and multivariate analyses.RESULTS: Of all patients, 368 (11.0%) had carcinoma in situ (CIS) and 197 (5.9%) had bilateral cancers. For the 2970 patients with invasive cancer, of which 49 patients (1.7%) had metastastic disease at time of diagnosis, DFS, LCR, DDFS, OS and ROS at 5 years were 79.8%, 84.7%, 81.2%, 86.3%, and 89.8%, respectively. In multivariate analysis age, pT category, nodal status, hormone receptor status and grading were identified as independent prognostic factors for OS.CONCLUSION: Compared with recent population-based reports from Germany, more favourable patient characteristics and nominally higher survival was found among this large cohort of patients with primary breast cancer treated at a single certified breast unit.

KW - Academic Medical Centers

KW - Adult

KW - Age Factors

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Breast Neoplasms

KW - Carcinoma

KW - Chemotherapy, Adjuvant

KW - Combined Modality Therapy

KW - Disease-Free Survival

KW - Female

KW - Germany

KW - Humans

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Radiotherapy, Adjuvant

KW - Survival Rate

KW - Treatment Outcome

KW - Women's Health

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.breast.2012.01.009

DO - 10.1016/j.breast.2012.01.009

M3 - SCORING: Journal article

C2 - 22310244

VL - 21

SP - 303

EP - 308

JO - BREAST

JF - BREAST

SN - 0960-9776

IS - 3

ER -