Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

Anna K Bonkhoff; Markus D Schirmer; Martin Bretzner; Sungmin Hong; Robert W Regenhardt; Mikael Brudfors; Kathleen L Donahue; Marco J Nardin; Adrian V Dalca; Anne-Katrin Giese; Mark R Etherton; Brandon L Hancock; Steven J T Mocking; Elissa C McIntosh; John Attia; Oscar R Benavente; Stephen Bevan; John W Cole; Amanda Donatti; Christoph J Griessenauer; Laura Heitsch; Lukas Holmegaard; Katarina Jood; Jordi Jimenez-Conde; Steven J Kittner; Robin Lemmens; Christopher R Levi; Caitrin W McDonough; James F Meschia; Chia-Ling Phuah; Arndt Rolfs; Stefan Ropele; Jonathan Rosand; Jaume Roquer; Tatjana Rundek; Ralph L Sacco; Reinhold Schmidt; Pankaj Sharma; Agnieszka Slowik; Martin Söderholm; Alessandro Sousa; Tara M Stanne; Daniel Strbian; Turgut Tatlisumak; Vincent Thijs; Achala Vagal; Johan Wasselius; Daniel Woo; Ramin Zand; Patrick F McArdle; Bradford B Worrall; Christina Jern; Arne G Lindgren; Jane Maguire; Danilo Bzdok; Ona Wu; Natalia S Rost

doi:10.1038/s41467-021-23492-3

Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

Standard

Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. / Bonkhoff, Anna K; Schirmer, Markus D; Bretzner, Martin; Hong, Sungmin; Regenhardt, Robert W; Brudfors, Mikael; Donahue, Kathleen L; Nardin, Marco J; Dalca, Adrian V; Giese, Anne-Katrin; Etherton, Mark R; Hancock, Brandon L; Mocking, Steven J T; McIntosh, Elissa C; Attia, John; Benavente, Oscar R; Bevan, Stephen; Cole, John W; Donatti, Amanda; Griessenauer, Christoph J; Heitsch, Laura; Holmegaard, Lukas; Jood, Katarina; Jimenez-Conde, Jordi; Kittner, Steven J; Lemmens, Robin; Levi, Christopher R; McDonough, Caitrin W; Meschia, James F; Phuah, Chia-Ling; Rolfs, Arndt; Ropele, Stefan; Rosand, Jonathan; Roquer, Jaume; Rundek, Tatjana; Sacco, Ralph L; Schmidt, Reinhold; Sharma, Pankaj; Slowik, Agnieszka; Söderholm, Martin; Sousa, Alessandro; Stanne, Tara M; Strbian, Daniel; Tatlisumak, Turgut; Thijs, Vincent; Vagal, Achala; Wasselius, Johan; Woo, Daniel; Zand, Ramin; McArdle, Patrick F; Worrall, Bradford B; Jern, Christina; Lindgren, Arne G; Maguire, Jane; Bzdok, Danilo; Wu, Ona; Rost, Natalia S.

In: NAT COMMUN, Vol. 12, No. 1, 3289, 02.06.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bonkhoff, AK, Schirmer, MD, Bretzner, M, Hong, S, Regenhardt, RW, Brudfors, M, Donahue, KL, Nardin, MJ, Dalca, AV, Giese, A-K, Etherton, MR, Hancock, BL, Mocking, SJT, McIntosh, EC, Attia, J, Benavente, OR, Bevan, S, Cole, JW, Donatti, A, Griessenauer, CJ, Heitsch, L, Holmegaard, L, Jood, K, Jimenez-Conde, J, Kittner, SJ, Lemmens, R, Levi, CR, McDonough, CW, Meschia, JF, Phuah, C-L, Rolfs, A, Ropele, S, Rosand, J, Roquer, J, Rundek, T, Sacco, RL, Schmidt, R, Sharma, P, Slowik, A, Söderholm, M, Sousa, A, Stanne, TM, Strbian, D, Tatlisumak, T, Thijs, V, Vagal, A, Wasselius, J, Woo, D, Zand, R, McArdle, PF, Worrall, BB, Jern, C, Lindgren, AG, Maguire, J, Bzdok, D, Wu, O & Rost, NS 2021, 'Outcome after acute ischemic stroke is linked to sex-specific lesion patterns', NAT COMMUN, vol. 12, no. 1, 3289. https://doi.org/10.1038/s41467-021-23492-3

APA

Bonkhoff, A. K., Schirmer, M. D., Bretzner, M., Hong, S., Regenhardt, R. W., Brudfors, M., Donahue, K. L., Nardin, M. J., Dalca, A. V., Giese, A-K., Etherton, M. R., Hancock, B. L., Mocking, S. J. T., McIntosh, E. C., Attia, J., Benavente, O. R., Bevan, S., Cole, J. W., Donatti, A., ... Rost, N. S. (2021). Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. NAT COMMUN, 12(1), [3289]. https://doi.org/10.1038/s41467-021-23492-3

Vancouver

Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Brudfors M et al. Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. NAT COMMUN. 2021 Jun 2;12(1). 3289. https://doi.org/10.1038/s41467-021-23492-3

Bibtex

@article{b385db57b5054dfabbe5bd3ba4919933,

title = "Outcome after acute ischemic stroke is linked to sex-specific lesion patterns",

abstract = "Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.",

keywords = "Aged, Aged, 80 and over, Bayes Theorem, Brain Mapping, Brain Stem/blood supply, Cerebral Revascularization/methods, Cohort Studies, Female, Humans, Image Processing, Computer-Assisted, Ischemic Stroke/diagnostic imaging, Magnetic Resonance Imaging, Male, Middle Aged, Risk Factors, Sensorimotor Cortex/blood supply, Severity of Illness Index, Sex Factors, Thalamus/blood supply, Treatment Outcome",

author = "Bonkhoff, {Anna K} and Schirmer, {Markus D} and Martin Bretzner and Sungmin Hong and Regenhardt, {Robert W} and Mikael Brudfors and Donahue, {Kathleen L} and Nardin, {Marco J} and Dalca, {Adrian V} and Anne-Katrin Giese and Etherton, {Mark R} and Hancock, {Brandon L} and Mocking, {Steven J T} and McIntosh, {Elissa C} and John Attia and Benavente, {Oscar R} and Stephen Bevan and Cole, {John W} and Amanda Donatti and Griessenauer, {Christoph J} and Laura Heitsch and Lukas Holmegaard and Katarina Jood and Jordi Jimenez-Conde and Kittner, {Steven J} and Robin Lemmens and Levi, {Christopher R} and McDonough, {Caitrin W} and Meschia, {James F} and Chia-Ling Phuah and Arndt Rolfs and Stefan Ropele and Jonathan Rosand and Jaume Roquer and Tatjana Rundek and Sacco, {Ralph L} and Reinhold Schmidt and Pankaj Sharma and Agnieszka Slowik and Martin S{\"o}derholm and Alessandro Sousa and Stanne, {Tara M} and Daniel Strbian and Turgut Tatlisumak and Vincent Thijs and Achala Vagal and Johan Wasselius and Daniel Woo and Ramin Zand and McArdle, {Patrick F} and Worrall, {Bradford B} and Christina Jern and Lindgren, {Arne G} and Jane Maguire and Danilo Bzdok and Ona Wu and Rost, {Natalia S}",

year = "2021",

month = jun,

day = "2",

doi = "10.1038/s41467-021-23492-3",

language = "English",

volume = "12",

journal = "NAT COMMUN",

issn = "2041-1723",

publisher = "NATURE PUBLISHING GROUP",

number = "1",

}

RIS

TY - JOUR

T1 - Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

AU - Bonkhoff, Anna K

AU - Schirmer, Markus D

AU - Bretzner, Martin

AU - Hong, Sungmin

AU - Regenhardt, Robert W

AU - Brudfors, Mikael

AU - Donahue, Kathleen L

AU - Nardin, Marco J

AU - Dalca, Adrian V

AU - Giese, Anne-Katrin

AU - Etherton, Mark R

AU - Hancock, Brandon L

AU - Mocking, Steven J T

AU - McIntosh, Elissa C

AU - Attia, John

AU - Benavente, Oscar R

AU - Bevan, Stephen

AU - Cole, John W

AU - Donatti, Amanda

AU - Griessenauer, Christoph J

AU - Heitsch, Laura

AU - Holmegaard, Lukas

AU - Jood, Katarina

AU - Jimenez-Conde, Jordi

AU - Kittner, Steven J

AU - Lemmens, Robin

AU - Levi, Christopher R

AU - McDonough, Caitrin W

AU - Meschia, James F

AU - Phuah, Chia-Ling

AU - Rolfs, Arndt

AU - Ropele, Stefan

AU - Rosand, Jonathan

AU - Roquer, Jaume

AU - Rundek, Tatjana

AU - Sacco, Ralph L

AU - Schmidt, Reinhold

AU - Sharma, Pankaj

AU - Slowik, Agnieszka

AU - Söderholm, Martin

AU - Sousa, Alessandro

AU - Stanne, Tara M

AU - Strbian, Daniel

AU - Tatlisumak, Turgut

AU - Thijs, Vincent

AU - Vagal, Achala

AU - Wasselius, Johan

AU - Woo, Daniel

AU - Zand, Ramin

AU - McArdle, Patrick F

AU - Worrall, Bradford B

AU - Jern, Christina

AU - Lindgren, Arne G

AU - Maguire, Jane

AU - Bzdok, Danilo

AU - Wu, Ona

AU - Rost, Natalia S

PY - 2021/6/2

Y1 - 2021/6/2

N2 - Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.

AB - Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.

KW - Aged

KW - Aged, 80 and over

KW - Bayes Theorem

KW - Brain Mapping

KW - Brain Stem/blood supply

KW - Cerebral Revascularization/methods

KW - Cohort Studies

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Ischemic Stroke/diagnostic imaging

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Sensorimotor Cortex/blood supply

KW - Severity of Illness Index

KW - Sex Factors

KW - Thalamus/blood supply

KW - Treatment Outcome

U2 - 10.1038/s41467-021-23492-3

DO - 10.1038/s41467-021-23492-3

M3 - SCORING: Journal article

C2 - 34078897

VL - 12

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 3289

ER -