Osteosarcoma of the mobile spine
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Osteosarcoma of the mobile spine. / Zils, K; Bielack, S; Wilhelm, M; Werner, M; Schwarz, Rudolf; Windhager, R; Hofmann-Wackersreuther, G; Andus, T; Kager, L; Kuehne, T; Reichardt, P; von Kalle, T.
In: ANN ONCOL, Vol. 24, No. 8, 01.08.2013, p. 2190-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Osteosarcoma of the mobile spine
AU - Zils, K
AU - Bielack, S
AU - Wilhelm, M
AU - Werner, M
AU - Schwarz, Rudolf
AU - Windhager, R
AU - Hofmann-Wackersreuther, G
AU - Andus, T
AU - Kager, L
AU - Kuehne, T
AU - Reichardt, P
AU - von Kalle, T
PY - 2013/8/1
Y1 - 2013/8/1
N2 - BACKGROUND: The aims of this analysis were to investigate features and outcome of high-grade osteosarcomas of the mobile spine.PATIENTS AND METHODS: Since 1977, 20 Cooperative Osteosarcoma Study Group patients had a diagnosis of high-grade osteosarcomas of the mobile spine and were included in this retrospective analysis of patient-, tumor- and treatment-related variables and outcome.RESULTS: The median age was 29 years (range 5-58). Most frequent tumor sites were thoracic and lumbar spine. All but three patients had nonmetastatic disease at diagnosis. Treatment included surgery and chemotherapy for all patients, 13 were also irradiated. Eight patients failed to achieve a macroscopically complete surgical remission (five local, one primary metastases, two both), six died, two are alive, both with radiotherapy. Of 12 patients with complete remission at all sites, three had a recurrence (two local, one metastases) and died. The median follow-up of the 11 survivors was 8.7 years (range 3.1-22.3), 5-year overall and event-free survival rates were 60% and 43%. Age <40 years, nonmetastatic disease at diagnosis and complete remission predicted for better overall survival (OS, P < 0.05).CONCLUSIONS: Osteosarcomas of the mobile spine are rare. With complete resection (and potentially radiotherapy) and chemotherapy, prognosis may be comparable with that of appendicular osteosarcomas.
AB - BACKGROUND: The aims of this analysis were to investigate features and outcome of high-grade osteosarcomas of the mobile spine.PATIENTS AND METHODS: Since 1977, 20 Cooperative Osteosarcoma Study Group patients had a diagnosis of high-grade osteosarcomas of the mobile spine and were included in this retrospective analysis of patient-, tumor- and treatment-related variables and outcome.RESULTS: The median age was 29 years (range 5-58). Most frequent tumor sites were thoracic and lumbar spine. All but three patients had nonmetastatic disease at diagnosis. Treatment included surgery and chemotherapy for all patients, 13 were also irradiated. Eight patients failed to achieve a macroscopically complete surgical remission (five local, one primary metastases, two both), six died, two are alive, both with radiotherapy. Of 12 patients with complete remission at all sites, three had a recurrence (two local, one metastases) and died. The median follow-up of the 11 survivors was 8.7 years (range 3.1-22.3), 5-year overall and event-free survival rates were 60% and 43%. Age <40 years, nonmetastatic disease at diagnosis and complete remission predicted for better overall survival (OS, P < 0.05).CONCLUSIONS: Osteosarcomas of the mobile spine are rare. With complete resection (and potentially radiotherapy) and chemotherapy, prognosis may be comparable with that of appendicular osteosarcomas.
KW - Adolescent
KW - Adult
KW - Child
KW - Child, Preschool
KW - Disease-Free Survival
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Neoplasm Recurrence, Local
KW - Osteosarcoma
KW - Pain
KW - Retrospective Studies
KW - Spine
KW - Survival Rate
KW - Treatment Outcome
KW - Young Adult
U2 - 10.1093/annonc/mdt154
DO - 10.1093/annonc/mdt154
M3 - SCORING: Journal article
C2 - 23613478
VL - 24
SP - 2190
EP - 2195
JO - ANN ONCOL
JF - ANN ONCOL
SN - 0923-7534
IS - 8
ER -
