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Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism

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Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. / Bozec, Aline; Bakiri, Latifa; Jimenez, Maria; Rosen, Evan D; Catalá-Lehnen, Philip; Schinke, Thorsten; Schett, Georg; Amling, Michael; Wagner, Erwin F.

In: J CELL SCI, Vol. 126, No. Pt 23, 01.12.2013, p. 5432-40.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bozec, A, Bakiri, L, Jimenez, M, Rosen, ED, Catalá-Lehnen, P, Schinke, T, Schett, G, Amling, M & Wagner, EF 2013, 'Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism', J CELL SCI, vol. 126, no. Pt 23, pp. 5432-40. https://doi.org/10.1242/jcs.134510

APA

Bozec, A., Bakiri, L., Jimenez, M., Rosen, E. D., Catalá-Lehnen, P., Schinke, T., Schett, G., Amling, M., & Wagner, E. F. (2013). Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. J CELL SCI, 126(Pt 23), 5432-40. https://doi.org/10.1242/jcs.134510

Vancouver

Bozec A, Bakiri L, Jimenez M, Rosen ED, Catalá-Lehnen P, Schinke T et al. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. J CELL SCI. 2013 Dec 1;126(Pt 23):5432-40. https://doi.org/10.1242/jcs.134510

Bibtex

@article{afc0b608fc194e47b4b064cbb98cf4d1,
title = "Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism",
abstract = "Recent studies have established that the skeleton functions as an endocrine organ affecting metabolism through the osteoblast-derived hormone osteocalcin (Ocn). However, it is not fully understood how many transcription factors expressed in osteoblasts regulate the endocrine function. Here, we show that mice with osteoblast-specific deletion of Fra-2 (Fosl2) have low bone mass but increased body weight. In contrast, transgenic expression of Fra-2 in osteoblasts leads to increased bone mass and decreased body weight accompanied by reduced serum glucose and insulin levels, improved glucose tolerance and insulin sensitivity. In addition, mice lacking Fra-2 have reduced levels of circulating Ocn, but high adiponectin (Adipoq), whereas Fra-2 transgenic mice exhibit high Ocn and low Adipoq levels. Moreover, we found that Adipoq was expressed in osteoblasts and that this expression was transcriptionally repressed by Fra-2. These results demonstrate that Fra-2 expression in osteoblasts represents a novel paradigm for a transcription factor controlling the endocrine function of the skeleton.",
author = "Aline Bozec and Latifa Bakiri and Maria Jimenez and Rosen, {Evan D} and Philip Catal{\'a}-Lehnen and Thorsten Schinke and Georg Schett and Michael Amling and Wagner, {Erwin F}",
year = "2013",
month = dec,
day = "1",
doi = "10.1242/jcs.134510",
language = "English",
volume = "126",
pages = "5432--40",
journal = "J CELL SCI",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "Pt 23",

}

RIS

TY - JOUR

T1 - Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism

AU - Bozec, Aline

AU - Bakiri, Latifa

AU - Jimenez, Maria

AU - Rosen, Evan D

AU - Catalá-Lehnen, Philip

AU - Schinke, Thorsten

AU - Schett, Georg

AU - Amling, Michael

AU - Wagner, Erwin F

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Recent studies have established that the skeleton functions as an endocrine organ affecting metabolism through the osteoblast-derived hormone osteocalcin (Ocn). However, it is not fully understood how many transcription factors expressed in osteoblasts regulate the endocrine function. Here, we show that mice with osteoblast-specific deletion of Fra-2 (Fosl2) have low bone mass but increased body weight. In contrast, transgenic expression of Fra-2 in osteoblasts leads to increased bone mass and decreased body weight accompanied by reduced serum glucose and insulin levels, improved glucose tolerance and insulin sensitivity. In addition, mice lacking Fra-2 have reduced levels of circulating Ocn, but high adiponectin (Adipoq), whereas Fra-2 transgenic mice exhibit high Ocn and low Adipoq levels. Moreover, we found that Adipoq was expressed in osteoblasts and that this expression was transcriptionally repressed by Fra-2. These results demonstrate that Fra-2 expression in osteoblasts represents a novel paradigm for a transcription factor controlling the endocrine function of the skeleton.

AB - Recent studies have established that the skeleton functions as an endocrine organ affecting metabolism through the osteoblast-derived hormone osteocalcin (Ocn). However, it is not fully understood how many transcription factors expressed in osteoblasts regulate the endocrine function. Here, we show that mice with osteoblast-specific deletion of Fra-2 (Fosl2) have low bone mass but increased body weight. In contrast, transgenic expression of Fra-2 in osteoblasts leads to increased bone mass and decreased body weight accompanied by reduced serum glucose and insulin levels, improved glucose tolerance and insulin sensitivity. In addition, mice lacking Fra-2 have reduced levels of circulating Ocn, but high adiponectin (Adipoq), whereas Fra-2 transgenic mice exhibit high Ocn and low Adipoq levels. Moreover, we found that Adipoq was expressed in osteoblasts and that this expression was transcriptionally repressed by Fra-2. These results demonstrate that Fra-2 expression in osteoblasts represents a novel paradigm for a transcription factor controlling the endocrine function of the skeleton.

U2 - 10.1242/jcs.134510

DO - 10.1242/jcs.134510

M3 - SCORING: Journal article

C2 - 24046454

VL - 126

SP - 5432

EP - 5440

JO - J CELL SCI

JF - J CELL SCI

SN - 0021-9533

IS - Pt 23

ER -