Oscillatory neuronal synchronization in primary visual cortex as a correlate of stimulus selection
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Oscillatory neuronal synchronization in primary visual cortex as a correlate of stimulus selection. / Fries, Pascal; Schröder, Jan-Hinrich; Roelfsema, Pieter R; Singer, Wolf; Engel, Andreas K.
In: J NEUROSCI, Vol. 22, No. 9, 01.05.2002, p. 3739-54.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Oscillatory neuronal synchronization in primary visual cortex as a correlate of stimulus selection
AU - Fries, Pascal
AU - Schröder, Jan-Hinrich
AU - Roelfsema, Pieter R
AU - Singer, Wolf
AU - Engel, Andreas K
PY - 2002/5/1
Y1 - 2002/5/1
N2 - Spike and local field potential activity were recorded simultaneously from multiple sites in primary visual cortex of strabismic cats, while monocular stimulation alternated with dichoptic stimulation, inducing interocular rivalry. During interocular rivalry, there is competition between the two nonfusible stimuli presented to the two eyes, and only one stimulus is selected at any time. We biased this competition in three different ways: (1) we exploited the condition that in strabismic cats there is often one dominant eye that is selected for most of the time. (2) We presented the two stimuli with a temporal offset, which biases competition in favor of the newly appearing stimulus. (3) We presented the two stimuli with highly different contrasts, which biases competition in favor of the stimulus with higher contrast. Whenever competition was biased in favor of the stimulus activating the recorded neurons, gamma-frequency synchronization of the respective responses was enhanced, and vice versa. Firing rates showed some differences between stimulation conditions. However, when present, these changes were inversely related to a competitive advantage of the respective stimulus. We hypothesize that enhanced gamma-frequency synchronization in primary visual cortex is a correlate of stimulus selection. Synchronization is likely to be translated into firing rate changes at later processing stages.
AB - Spike and local field potential activity were recorded simultaneously from multiple sites in primary visual cortex of strabismic cats, while monocular stimulation alternated with dichoptic stimulation, inducing interocular rivalry. During interocular rivalry, there is competition between the two nonfusible stimuli presented to the two eyes, and only one stimulus is selected at any time. We biased this competition in three different ways: (1) we exploited the condition that in strabismic cats there is often one dominant eye that is selected for most of the time. (2) We presented the two stimuli with a temporal offset, which biases competition in favor of the newly appearing stimulus. (3) We presented the two stimuli with highly different contrasts, which biases competition in favor of the stimulus with higher contrast. Whenever competition was biased in favor of the stimulus activating the recorded neurons, gamma-frequency synchronization of the respective responses was enhanced, and vice versa. Firing rates showed some differences between stimulation conditions. However, when present, these changes were inversely related to a competitive advantage of the respective stimulus. We hypothesize that enhanced gamma-frequency synchronization in primary visual cortex is a correlate of stimulus selection. Synchronization is likely to be translated into firing rate changes at later processing stages.
KW - Action Potentials
KW - Animals
KW - Biological Clocks
KW - Cats
KW - Contrast Sensitivity
KW - Convergence, Ocular
KW - Dominance, Ocular
KW - Electrooculography
KW - Eye Movements
KW - Neurons
KW - Photic Stimulation
KW - Signal Processing, Computer-Assisted
KW - Strabismus
KW - Visual Cortex
KW - Wakefulness
U2 - 20026318
DO - 20026318
M3 - SCORING: Journal article
C2 - 11978850
VL - 22
SP - 3739
EP - 3754
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 9
ER -