Orthotopic models of esophageal carcinoma and their use in drug discovery.
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Orthotopic models of esophageal carcinoma and their use in drug discovery. / Gros, Stephanie; Stephanie, J.
In: Curr Protoc Pharmacol, Vol. Chapter 14, 2011, p. 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Orthotopic models of esophageal carcinoma and their use in drug discovery.
AU - Gros, Stephanie
AU - Stephanie, J
PY - 2011
Y1 - 2011
N2 - The protocol detailed in this unit is for the establishment of an orthotopic model of human esophageal adenocarcinoma in NMRI/nu mice. The resultant tumor has high metastatic potential, spreading readily to liver, lungs, and lymph nodes. This model is useful for studying primary esophageal carcinoma, tumor biology, pathogenesis, tumor progression, metastatic homing, and the efficacy of therapeutic approaches for treating this condition. The practical use of this preclinical model for drug discovery is illustrated with data from a study on the chemotherapeutic effects of HER2-targeted therapy.
AB - The protocol detailed in this unit is for the establishment of an orthotopic model of human esophageal adenocarcinoma in NMRI/nu mice. The resultant tumor has high metastatic potential, spreading readily to liver, lungs, and lymph nodes. This model is useful for studying primary esophageal carcinoma, tumor biology, pathogenesis, tumor progression, metastatic homing, and the efficacy of therapeutic approaches for treating this condition. The practical use of this preclinical model for drug discovery is illustrated with data from a study on the chemotherapeutic effects of HER2-targeted therapy.
KW - Animals
KW - Humans
KW - Mice
KW - Cell Line, Tumor
KW - Mice, Nude
KW - Antineoplastic Agents/therapeutic use
KW - Adenocarcinoma/drug therapy/pathology
KW - Drug Discovery/methods
KW - Esophageal Neoplasms/drug therapy/pathology
KW - Xenograft Model Antitumor Assays/methods
KW - Animals
KW - Humans
KW - Mice
KW - Cell Line, Tumor
KW - Mice, Nude
KW - Antineoplastic Agents/therapeutic use
KW - Adenocarcinoma/drug therapy/pathology
KW - Drug Discovery/methods
KW - Esophageal Neoplasms/drug therapy/pathology
KW - Xenograft Model Antitumor Assays/methods
M3 - SCORING: Journal article
VL - Chapter 14
SP - 20
JO - Curr Protoc Pharmacol
JF - Curr Protoc Pharmacol
SN - 1934-8290
ER -
