Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients.
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Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients. / Kramme, Stefanie; An, Le Van; Khoa, Nguyen Dinh; Trin, Le Van; Tannich, Egbert; Rybniker, Jan; Fleischer, Bernhard; Drosten, Christian; Panning, Marcus.
In: J CLIN MICROBIOL, Vol. 47, No. 3, 3, 2009, p. 586-589.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients.
AU - Kramme, Stefanie
AU - An, Le Van
AU - Khoa, Nguyen Dinh
AU - Trin, Le Van
AU - Tannich, Egbert
AU - Rybniker, Jan
AU - Fleischer, Bernhard
AU - Drosten, Christian
AU - Panning, Marcus
PY - 2009
Y1 - 2009
N2 - Scrub typhus, caused by the intracellular bacterium Orientia tsutsugamushi, is a major cause of febrile illness in the Asia/Pacific region. Here, we implemented a novel real-time PCR and determined the relation of DNA target gene concentration with serum cytokine levels. The limit of detection of the novel real-time PCR was 1,062 DNA copies per ml of EDTA whole blood. Specificity was excellent as determined on a panel of blood- and skin-borne bacteria, including Rickettsia spp. as well as healthy Vietnamese blood donors. Bacterial DNA concentrations after 9 to 12 days from symptoms onset were significantly higher than in earlier or later periods (P
AB - Scrub typhus, caused by the intracellular bacterium Orientia tsutsugamushi, is a major cause of febrile illness in the Asia/Pacific region. Here, we implemented a novel real-time PCR and determined the relation of DNA target gene concentration with serum cytokine levels. The limit of detection of the novel real-time PCR was 1,062 DNA copies per ml of EDTA whole blood. Specificity was excellent as determined on a panel of blood- and skin-borne bacteria, including Rickettsia spp. as well as healthy Vietnamese blood donors. Bacterial DNA concentrations after 9 to 12 days from symptoms onset were significantly higher than in earlier or later periods (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 47
SP - 586
EP - 589
JO - J CLIN MICROBIOL
JF - J CLIN MICROBIOL
SN - 0095-1137
IS - 3
M1 - 3
ER -