Research ExplorerPublicationsOrgan manifestations of COVID-19: what have we learned so fa...

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

Standard

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? / Jonigk, Danny; Werlein, Christopher; Acker, Till; Aepfelbacher, Martin; Amann, Kerstin U; Baretton, Gustavo; Barth, Peter; Bohle, Rainer M; Büttner, Andreas; Büttner, Reinhard; Dettmeyer, Reinhard; Eichhorn, Philip; Elezkurtaj, Sefer; Esposito, Irene; Evert, Katja; Evert, Matthias; Fend, Falko; Gaßler, Nikolaus; Gattenlöhner, Stefan; Glatzel, Markus; Göbel, Heike; Gradhand, Elise; Hansen, Torsten; Hartmann, Arndt; Heinemann, Axel; Heppner, Frank L; Hilsenbeck, Julia; Horst, David; Kamp, Jan C; Mall, Gita; Märkl, Bruno; Ondruschka, Benjamin; Pablik, Jessica; Pfefferle, Susanne; Quaas, Alexander; Radbruch, Helena; Röcken, Christoph; Rosenwald, Andreas; Roth, Wilfried; Rudelius, Martina; Schirmacher, Peter; Slotta-Huspenina, Julia; Smith, Kevin; Sommer, Linna; Stock, Konrad; Ströbel, Philipp; Strobl, Stephanie; Titze, Ulf; Weirich, Gregor; Weis, Joachim; Werner, Martin; Wickenhauser, Claudia; Wiech, Thorsten; Wild, Peter; Welte, Tobias; von Stillfried, Saskia; Boor, Peter.

In: VIRCHOWS ARCH, Vol. 481, No. 2, 08.2022, p. 139-159.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Jonigk, D, Werlein, C, Acker, T, Aepfelbacher, M, Amann, KU, Baretton, G, Barth, P, Bohle, RM, Büttner, A, Büttner, R, Dettmeyer, R, Eichhorn, P, Elezkurtaj, S, Esposito, I, Evert, K, Evert, M, Fend, F, Gaßler, N, Gattenlöhner, S, Glatzel, M, Göbel, H, Gradhand, E, Hansen, T, Hartmann, A, Heinemann, A, Heppner, FL, Hilsenbeck, J, Horst, D, Kamp, JC, Mall, G, Märkl, B, Ondruschka, B, Pablik, J, Pfefferle, S, Quaas, A, Radbruch, H, Röcken, C, Rosenwald, A, Roth, W, Rudelius, M, Schirmacher, P, Slotta-Huspenina, J, Smith, K, Sommer, L, Stock, K, Ströbel, P, Strobl, S, Titze, U, Weirich, G, Weis, J, Werner, M, Wickenhauser, C, Wiech, T, Wild, P, Welte, T, von Stillfried, S & Boor, P 2022, 'Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?', VIRCHOWS ARCH, vol. 481, no. 2, pp. 139-159. https://doi.org/10.1007/s00428-022-03319-2

APA

Jonigk, D., Werlein, C., Acker, T., Aepfelbacher, M., Amann, K. U., Baretton, G., Barth, P., Bohle, R. M., Büttner, A., Büttner, R., Dettmeyer, R., Eichhorn, P., Elezkurtaj, S., Esposito, I., Evert, K., Evert, M., Fend, F., Gaßler, N., Gattenlöhner, S., ... Boor, P. (2022). Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? VIRCHOWS ARCH, 481(2), 139-159. https://doi.org/10.1007/s00428-022-03319-2

Vancouver

Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G et al. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? VIRCHOWS ARCH. 2022 Aug;481(2):139-159. https://doi.org/10.1007/s00428-022-03319-2

Bibtex

@article{edb4172481404099b524f3543859e92b,
title = "Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?",
abstract = "The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autopsy techniques, the applicability of modern analytical methods to understand the pathophysiology of COVID-19, the major pathological organ findings, limitations or current studies, and open questions. This article summarizes published literature and the consented experience of the nationwide network of clinical, neuro-, and forensic pathologists from 27 German autopsy centers with more than 1200 COVID-19 autopsies. The autopsy tissues revealed that SARS-CoV-2 can be found in virtually all human organs and tissues, and the majority of cells. Autopsies have revealed the organ and tissue tropism of SARS-CoV-2, and the morphological features of COVID-19. This is characterized by diffuse alveolar damage, combined with angiocentric disease, which in turn is characterized by endothelial dysfunction, vascular inflammation, (micro-) thrombosis, vasoconstriction, and intussusceptive angiogenesis. These findings explained the increased pulmonary resistance in COVID-19 and supported the recommendations for antithrombotic treatment in COVID-19. In contrast, in extra-respiratory organs, pathological changes are often nonspecific and unclear to which extent these changes are due to direct infection vs. indirect/secondary mechanisms of organ injury, or a combination thereof. Ongoing research using autopsies aims at answering questions on disease mechanisms, e.g., focusing on variants of concern, and future challenges, such as post-COVID conditions. Autopsies are an invaluable tool in medicine and national and international interdisciplinary collaborative autopsy-based research initiatives are essential.",
keywords = "Autopsy, COVID-19, Humans, Lung/pathology, Pandemics, SARS-CoV-2",
author = "Danny Jonigk and Christopher Werlein and Till Acker and Martin Aepfelbacher and Amann, {Kerstin U} and Gustavo Baretton and Peter Barth and Bohle, {Rainer M} and Andreas B{\"u}ttner and Reinhard B{\"u}ttner and Reinhard Dettmeyer and Philip Eichhorn and Sefer Elezkurtaj and Irene Esposito and Katja Evert and Matthias Evert and Falko Fend and Nikolaus Ga{\ss}ler and Stefan Gattenl{\"o}hner and Markus Glatzel and Heike G{\"o}bel and Elise Gradhand and Torsten Hansen and Arndt Hartmann and Axel Heinemann and Heppner, {Frank L} and Julia Hilsenbeck and David Horst and Kamp, {Jan C} and Gita Mall and Bruno M{\"a}rkl and Benjamin Ondruschka and Jessica Pablik and Susanne Pfefferle and Alexander Quaas and Helena Radbruch and Christoph R{\"o}cken and Andreas Rosenwald and Wilfried Roth and Martina Rudelius and Peter Schirmacher and Julia Slotta-Huspenina and Kevin Smith and Linna Sommer and Konrad Stock and Philipp Str{\"o}bel and Stephanie Strobl and Ulf Titze and Gregor Weirich and Joachim Weis and Martin Werner and Claudia Wickenhauser and Thorsten Wiech and Peter Wild and Tobias Welte and {von Stillfried}, Saskia and Peter Boor",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = aug,
doi = "10.1007/s00428-022-03319-2",
language = "English",
volume = "481",
pages = "139--159",
journal = "VIRCHOWS ARCH",
issn = "0945-6317",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

AU - Jonigk, Danny

AU - Werlein, Christopher

AU - Acker, Till

AU - Aepfelbacher, Martin

AU - Amann, Kerstin U

AU - Baretton, Gustavo

AU - Barth, Peter

AU - Bohle, Rainer M

AU - Büttner, Andreas

AU - Büttner, Reinhard

AU - Dettmeyer, Reinhard

AU - Eichhorn, Philip

AU - Elezkurtaj, Sefer

AU - Esposito, Irene

AU - Evert, Katja

AU - Evert, Matthias

AU - Fend, Falko

AU - Gaßler, Nikolaus

AU - Gattenlöhner, Stefan

AU - Glatzel, Markus

AU - Göbel, Heike

AU - Gradhand, Elise

AU - Hansen, Torsten

AU - Hartmann, Arndt

AU - Heinemann, Axel

AU - Heppner, Frank L

AU - Hilsenbeck, Julia

AU - Horst, David

AU - Kamp, Jan C

AU - Mall, Gita

AU - Märkl, Bruno

AU - Ondruschka, Benjamin

AU - Pablik, Jessica

AU - Pfefferle, Susanne

AU - Quaas, Alexander

AU - Radbruch, Helena

AU - Röcken, Christoph

AU - Rosenwald, Andreas

AU - Roth, Wilfried

AU - Rudelius, Martina

AU - Schirmacher, Peter

AU - Slotta-Huspenina, Julia

AU - Smith, Kevin

AU - Sommer, Linna

AU - Stock, Konrad

AU - Ströbel, Philipp

AU - Strobl, Stephanie

AU - Titze, Ulf

AU - Weirich, Gregor

AU - Weis, Joachim

AU - Werner, Martin

AU - Wickenhauser, Claudia

AU - Wiech, Thorsten

AU - Wild, Peter

AU - Welte, Tobias

AU - von Stillfried, Saskia

AU - Boor, Peter

N1 - © 2022. The Author(s).

PY - 2022/8

Y1 - 2022/8

N2 - The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autopsy techniques, the applicability of modern analytical methods to understand the pathophysiology of COVID-19, the major pathological organ findings, limitations or current studies, and open questions. This article summarizes published literature and the consented experience of the nationwide network of clinical, neuro-, and forensic pathologists from 27 German autopsy centers with more than 1200 COVID-19 autopsies. The autopsy tissues revealed that SARS-CoV-2 can be found in virtually all human organs and tissues, and the majority of cells. Autopsies have revealed the organ and tissue tropism of SARS-CoV-2, and the morphological features of COVID-19. This is characterized by diffuse alveolar damage, combined with angiocentric disease, which in turn is characterized by endothelial dysfunction, vascular inflammation, (micro-) thrombosis, vasoconstriction, and intussusceptive angiogenesis. These findings explained the increased pulmonary resistance in COVID-19 and supported the recommendations for antithrombotic treatment in COVID-19. In contrast, in extra-respiratory organs, pathological changes are often nonspecific and unclear to which extent these changes are due to direct infection vs. indirect/secondary mechanisms of organ injury, or a combination thereof. Ongoing research using autopsies aims at answering questions on disease mechanisms, e.g., focusing on variants of concern, and future challenges, such as post-COVID conditions. Autopsies are an invaluable tool in medicine and national and international interdisciplinary collaborative autopsy-based research initiatives are essential.

AB - The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autopsy techniques, the applicability of modern analytical methods to understand the pathophysiology of COVID-19, the major pathological organ findings, limitations or current studies, and open questions. This article summarizes published literature and the consented experience of the nationwide network of clinical, neuro-, and forensic pathologists from 27 German autopsy centers with more than 1200 COVID-19 autopsies. The autopsy tissues revealed that SARS-CoV-2 can be found in virtually all human organs and tissues, and the majority of cells. Autopsies have revealed the organ and tissue tropism of SARS-CoV-2, and the morphological features of COVID-19. This is characterized by diffuse alveolar damage, combined with angiocentric disease, which in turn is characterized by endothelial dysfunction, vascular inflammation, (micro-) thrombosis, vasoconstriction, and intussusceptive angiogenesis. These findings explained the increased pulmonary resistance in COVID-19 and supported the recommendations for antithrombotic treatment in COVID-19. In contrast, in extra-respiratory organs, pathological changes are often nonspecific and unclear to which extent these changes are due to direct infection vs. indirect/secondary mechanisms of organ injury, or a combination thereof. Ongoing research using autopsies aims at answering questions on disease mechanisms, e.g., focusing on variants of concern, and future challenges, such as post-COVID conditions. Autopsies are an invaluable tool in medicine and national and international interdisciplinary collaborative autopsy-based research initiatives are essential.

KW - Autopsy

KW - COVID-19

KW - Humans

KW - Lung/pathology

KW - Pandemics

KW - SARS-CoV-2

U2 - 10.1007/s00428-022-03319-2

DO - 10.1007/s00428-022-03319-2

M3 - SCORING: Review article

C2 - 35364700

VL - 481

SP - 139

EP - 159

JO - VIRCHOWS ARCH

JF - VIRCHOWS ARCH

SN - 0945-6317

IS - 2

ER -