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Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls

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Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls. / Dell, Leigh-Anne; Spocter, Muhammad A; Patzke, Nina; Karlson, Karl Æ; Alagaili, Abdulaziz N; Bennett, Nigel C; Muhammed, Osama B; Bertelsen, Mads F; Siegel, Jerome M; Manger, Paul R.

In: J CHEM NEUROANAT, Vol. 68, 10.2015, p. 61-76.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dell, L-A, Spocter, MA, Patzke, N, Karlson, KÆ, Alagaili, AN, Bennett, NC, Muhammed, OB, Bertelsen, MF, Siegel, JM & Manger, PR 2015, 'Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls', J CHEM NEUROANAT, vol. 68, pp. 61-76. https://doi.org/10.1016/j.jchemneu.2015.07.007

APA

Dell, L-A., Spocter, M. A., Patzke, N., Karlson, K. Æ., Alagaili, A. N., Bennett, N. C., Muhammed, O. B., Bertelsen, M. F., Siegel, J. M., & Manger, P. R. (2015). Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls. J CHEM NEUROANAT, 68, 61-76. https://doi.org/10.1016/j.jchemneu.2015.07.007

Vancouver

Dell L-A, Spocter MA, Patzke N, Karlson KÆ, Alagaili AN, Bennett NC et al. Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls. J CHEM NEUROANAT. 2015 Oct;68:61-76. https://doi.org/10.1016/j.jchemneu.2015.07.007

Bibtex

@article{4a0cb7eaf77a49fb8bedf8ee98449f73,
title = "Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls",
abstract = "The species of the cetacean and artiodactyl suborders, which constitute the order Cetartiodactyla, exhibit very different sleep phenomenology, with artiodactyls showing typical bihemispheric slow wave and REM sleep, while cetaceans show unihemispheric slow wave sleep and appear to lack REM sleep. The aim of this study was to determine whether cetaceans and artiodactyls have differently organized orexinergic arousal systems by examining the density of orexinergic innervation to the cerebral cortex, as this projection will be involved in various aspects of cortical arousal. This study provides a comparison of orexinergic bouton density in the cerebral cortex of twelve Cetartiodactyla species (ten artiodactyls and two cetaceans) by means of immunohistochemical staining and stereological analysis. It was found that the morphology of the axonal projections of the orexinergic system to the cerebral cortex was similar across all species, as the presence, size and proportion of large and small orexinergic boutons were similar. Despite this, orexinergic bouton density was lower in the cerebral cortex of the cetaceans studied compared to the artiodactyls studied, even when corrected for brain mass, neuron density, glial density and glial:neuron ratio. Results from correlational and principal component analyses indicate that glial density is a major determinant of the observed differences between artiodactyl and cetacean cortical orexinergic bouton density. ",
keywords = "Animals, Artiodactyla, Biological Evolution, Cell Count, Cell Size, Cerebral Cortex, Cetacea, Immunohistochemistry, Neuroglia, Neurons, Orexins, Presynaptic Terminals, Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Leigh-Anne Dell and Spocter, {Muhammad A} and Nina Patzke and Karlson, {Karl {\AE}} and Alagaili, {Abdulaziz N} and Bennett, {Nigel C} and Muhammed, {Osama B} and Bertelsen, {Mads F} and Siegel, {Jerome M} and Manger, {Paul R}",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2015",
month = oct,
doi = "10.1016/j.jchemneu.2015.07.007",
language = "English",
volume = "68",
pages = "61--76",
journal = "J CHEM NEUROANAT",
issn = "0891-0618",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls

AU - Dell, Leigh-Anne

AU - Spocter, Muhammad A

AU - Patzke, Nina

AU - Karlson, Karl Æ

AU - Alagaili, Abdulaziz N

AU - Bennett, Nigel C

AU - Muhammed, Osama B

AU - Bertelsen, Mads F

AU - Siegel, Jerome M

AU - Manger, Paul R

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2015/10

Y1 - 2015/10

N2 - The species of the cetacean and artiodactyl suborders, which constitute the order Cetartiodactyla, exhibit very different sleep phenomenology, with artiodactyls showing typical bihemispheric slow wave and REM sleep, while cetaceans show unihemispheric slow wave sleep and appear to lack REM sleep. The aim of this study was to determine whether cetaceans and artiodactyls have differently organized orexinergic arousal systems by examining the density of orexinergic innervation to the cerebral cortex, as this projection will be involved in various aspects of cortical arousal. This study provides a comparison of orexinergic bouton density in the cerebral cortex of twelve Cetartiodactyla species (ten artiodactyls and two cetaceans) by means of immunohistochemical staining and stereological analysis. It was found that the morphology of the axonal projections of the orexinergic system to the cerebral cortex was similar across all species, as the presence, size and proportion of large and small orexinergic boutons were similar. Despite this, orexinergic bouton density was lower in the cerebral cortex of the cetaceans studied compared to the artiodactyls studied, even when corrected for brain mass, neuron density, glial density and glial:neuron ratio. Results from correlational and principal component analyses indicate that glial density is a major determinant of the observed differences between artiodactyl and cetacean cortical orexinergic bouton density.

AB - The species of the cetacean and artiodactyl suborders, which constitute the order Cetartiodactyla, exhibit very different sleep phenomenology, with artiodactyls showing typical bihemispheric slow wave and REM sleep, while cetaceans show unihemispheric slow wave sleep and appear to lack REM sleep. The aim of this study was to determine whether cetaceans and artiodactyls have differently organized orexinergic arousal systems by examining the density of orexinergic innervation to the cerebral cortex, as this projection will be involved in various aspects of cortical arousal. This study provides a comparison of orexinergic bouton density in the cerebral cortex of twelve Cetartiodactyla species (ten artiodactyls and two cetaceans) by means of immunohistochemical staining and stereological analysis. It was found that the morphology of the axonal projections of the orexinergic system to the cerebral cortex was similar across all species, as the presence, size and proportion of large and small orexinergic boutons were similar. Despite this, orexinergic bouton density was lower in the cerebral cortex of the cetaceans studied compared to the artiodactyls studied, even when corrected for brain mass, neuron density, glial density and glial:neuron ratio. Results from correlational and principal component analyses indicate that glial density is a major determinant of the observed differences between artiodactyl and cetacean cortical orexinergic bouton density.

KW - Animals

KW - Artiodactyla

KW - Biological Evolution

KW - Cell Count

KW - Cell Size

KW - Cerebral Cortex

KW - Cetacea

KW - Immunohistochemistry

KW - Neuroglia

KW - Neurons

KW - Orexins

KW - Presynaptic Terminals

KW - Comparative Study

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jchemneu.2015.07.007

DO - 10.1016/j.jchemneu.2015.07.007

M3 - SCORING: Journal article

C2 - 26232521

VL - 68

SP - 61

EP - 76

JO - J CHEM NEUROANAT

JF - J CHEM NEUROANAT

SN - 0891-0618

ER -