Optische Kohärenztomographie zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg
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Optische Kohärenztomographie zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg. / Volgger, V; Arens, C; Kraft, M; Englhard, A S; Betz, C S.
In: HNO, Vol. 64, No. 1, 01.2016, p. 34-40.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Optische Kohärenztomographie zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg
AU - Volgger, V
AU - Arens, C
AU - Kraft, M
AU - Englhard, A S
AU - Betz, C S
PY - 2016/1
Y1 - 2016/1
N2 - BACKGROUND: Gold standard in the evaluation of upper aerodigestive tract (UADT) lesions is white light endoscopy followed by invasive tissue biopsy. This procedure is time consuming and expensive. Optical coherence tomography (OCT) is a noninvasive method, which provides high resolution, cross-sectional images of superficial tissue layers in real time.OBJECTIVE: This article aims to present a contemporary and comprehensive review on the role of OCT in differentiating between epithelial dysplasias and early invasive carcinomas of the UADT.MATERIALS AND METHODS: PubMed was searched using "optical coherence tomography/larynx" and other appropriate search strings in August 2015.RESULTS: OCT enables differentiation between benign, premalignant, and early malignant lesions of the UADT with high sensitivity and specificity. In addition, OCT holds promise as a clinical tool for guidance of surgical biopsies, follow-up of recurrent lesions, and for demarcation of tumor margins. Inadequate evidence and technical limitations hamper implementation of OCT into clinical routine.CONCLUSION: If the aforementioned problems are successfully solved, OCT seems to have the potential to substantially improve both diagnosis and management of precancerous and early cancerous lesions of the UADT.
AB - BACKGROUND: Gold standard in the evaluation of upper aerodigestive tract (UADT) lesions is white light endoscopy followed by invasive tissue biopsy. This procedure is time consuming and expensive. Optical coherence tomography (OCT) is a noninvasive method, which provides high resolution, cross-sectional images of superficial tissue layers in real time.OBJECTIVE: This article aims to present a contemporary and comprehensive review on the role of OCT in differentiating between epithelial dysplasias and early invasive carcinomas of the UADT.MATERIALS AND METHODS: PubMed was searched using "optical coherence tomography/larynx" and other appropriate search strings in August 2015.RESULTS: OCT enables differentiation between benign, premalignant, and early malignant lesions of the UADT with high sensitivity and specificity. In addition, OCT holds promise as a clinical tool for guidance of surgical biopsies, follow-up of recurrent lesions, and for demarcation of tumor margins. Inadequate evidence and technical limitations hamper implementation of OCT into clinical routine.CONCLUSION: If the aforementioned problems are successfully solved, OCT seems to have the potential to substantially improve both diagnosis and management of precancerous and early cancerous lesions of the UADT.
KW - Early Detection of Cancer
KW - Gastrointestinal Neoplasms
KW - Humans
KW - Image Enhancement
KW - Neoplasm Invasiveness
KW - Neoplasms, Glandular and Epithelial
KW - Precancerous Conditions
KW - Reproducibility of Results
KW - Respiratory Tract Neoplasms
KW - Sensitivity and Specificity
KW - Tomography, Optical Coherence
KW - Journal Article
KW - Review
U2 - 10.1007/s00106-015-0102-x
DO - 10.1007/s00106-015-0102-x
M3 - SCORING: Review
C2 - 26666557
VL - 64
SP - 34
EP - 40
JO - HNO
JF - HNO
SN - 0017-6192
IS - 1
ER -
