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Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta

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Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta. / Aziz, Atiqullah; Gierth, Michael; Rink, Michael; Schmid, Marianne; Chun, Felix K; Dahlem, Roland; Roghmann, Florian; Palisaar, Rein-Jüri; Noldus, Joachim; Ellinger, Jörg; Müller, Stefan C; Pycha, Armin; Martini, Thomas; Bolenz, Christian; Moritz, Rudolf; Herrmann, Edwin; Keck, Bastian; Wullich, Bernd; Mayr, Roman; Fritsche, Hans-Martin; Burger, Maximilian; Bastian, Patrick J; Seitz, Christian; Brookman-May, Sabine; Xylinas, Evanguelos; Shariat, Shahrokh F; Fisch, Margit; May, Matthias; PROMETRICS 2011 study group.

In: WORLD J UROL, Vol. 33, No. 12, 07.05.2015, p. 1945-1950.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Aziz, A, Gierth, M, Rink, M, Schmid, M, Chun, FK, Dahlem, R, Roghmann, F, Palisaar, R-J, Noldus, J, Ellinger, J, Müller, SC, Pycha, A, Martini, T, Bolenz, C, Moritz, R, Herrmann, E, Keck, B, Wullich, B, Mayr, R, Fritsche, H-M, Burger, M, Bastian, PJ, Seitz, C, Brookman-May, S, Xylinas, E, Shariat, SF, Fisch, M, May, M & PROMETRICS 2011 study group 2015, 'Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta', WORLD J UROL, vol. 33, no. 12, pp. 1945-1950. https://doi.org/10.1007/s00345-015-1572-x

APA

Aziz, A., Gierth, M., Rink, M., Schmid, M., Chun, F. K., Dahlem, R., Roghmann, F., Palisaar, R-J., Noldus, J., Ellinger, J., Müller, S. C., Pycha, A., Martini, T., Bolenz, C., Moritz, R., Herrmann, E., Keck, B., Wullich, B., Mayr, R., ... PROMETRICS 2011 study group (2015). Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta. WORLD J UROL, 33(12), 1945-1950. https://doi.org/10.1007/s00345-015-1572-x

Vancouver

Aziz A, Gierth M, Rink M, Schmid M, Chun FK, Dahlem R et al. Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta. WORLD J UROL. 2015 May 7;33(12):1945-1950. https://doi.org/10.1007/s00345-015-1572-x

Bibtex

@article{e345307a197f4d8c8663830398ff0187,
title = "Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta",
abstract = "Radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB) is associated with heterogeneous functional and oncological outcomes. The aim of this study was to generate trifecta and pentafecta criteria to optimize outcome reporting after RC.METHODS: We interviewed 50 experts to consider a virtual group of patients (age ≤ 75 years, ASA score ≤ 3) undergoing RC for a cT2 UCB and a final histology of ≤pT3pN0M0. A ranking was generated for the three and five criteria with the highest sum score. The criteria were applied to the Prospective Multicenter Radical Cystectomy Series 2011. Multivariable binary logistic regression analyses were used to evaluate the impact of clinical and histopathological parameters on meeting the top selected criteria.RESULTS: The criteria with the highest sum score were negative soft tissue surgical margin, lymph node (LN) dissection of at least 16 LNs, no complications according to Clavien-Dindo grade 3-5 within 90 days after RC, treatment-free time between TUR-BT with detection of muscle-invasive UCB and RC <3 months and the absence of local UCB-recurrence in the pelvis ≤12 months. The first three criteria formed trifecta, and all five criteria pentafecta. A total of 334 patients qualified for final analysis, whereas 35.3 and 29 % met trifecta and pentafecta criteria, respectively. Multivariable analyses showed that the relative probability of meeting trifecta and pentafecta decreases with higher age (3.2 %, p = 0.043 and 3.3 %, p = 0.042) per year, respectively.CONCLUSIONS: Trifecta and pentafecta incorporate essential criteria in terms of outcome reporting and might be considered for the improvement of standardized quality assessment after RC for UCB.",
author = "Atiqullah Aziz and Michael Gierth and Michael Rink and Marianne Schmid and Chun, {Felix K} and Roland Dahlem and Florian Roghmann and Rein-J{\"u}ri Palisaar and Joachim Noldus and J{\"o}rg Ellinger and M{\"u}ller, {Stefan C} and Armin Pycha and Thomas Martini and Christian Bolenz and Rudolf Moritz and Edwin Herrmann and Bastian Keck and Bernd Wullich and Roman Mayr and Hans-Martin Fritsche and Maximilian Burger and Bastian, {Patrick J} and Christian Seitz and Sabine Brookman-May and Evanguelos Xylinas and Shariat, {Shahrokh F} and Margit Fisch and Matthias May and {PROMETRICS 2011 study group}",
year = "2015",
month = may,
day = "7",
doi = "10.1007/s00345-015-1572-x",
language = "English",
volume = "33",
pages = "1945--1950",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta

AU - Aziz, Atiqullah

AU - Gierth, Michael

AU - Rink, Michael

AU - Schmid, Marianne

AU - Chun, Felix K

AU - Dahlem, Roland

AU - Roghmann, Florian

AU - Palisaar, Rein-Jüri

AU - Noldus, Joachim

AU - Ellinger, Jörg

AU - Müller, Stefan C

AU - Pycha, Armin

AU - Martini, Thomas

AU - Bolenz, Christian

AU - Moritz, Rudolf

AU - Herrmann, Edwin

AU - Keck, Bastian

AU - Wullich, Bernd

AU - Mayr, Roman

AU - Fritsche, Hans-Martin

AU - Burger, Maximilian

AU - Bastian, Patrick J

AU - Seitz, Christian

AU - Brookman-May, Sabine

AU - Xylinas, Evanguelos

AU - Shariat, Shahrokh F

AU - Fisch, Margit

AU - May, Matthias

AU - PROMETRICS 2011 study group

PY - 2015/5/7

Y1 - 2015/5/7

N2 - Radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB) is associated with heterogeneous functional and oncological outcomes. The aim of this study was to generate trifecta and pentafecta criteria to optimize outcome reporting after RC.METHODS: We interviewed 50 experts to consider a virtual group of patients (age ≤ 75 years, ASA score ≤ 3) undergoing RC for a cT2 UCB and a final histology of ≤pT3pN0M0. A ranking was generated for the three and five criteria with the highest sum score. The criteria were applied to the Prospective Multicenter Radical Cystectomy Series 2011. Multivariable binary logistic regression analyses were used to evaluate the impact of clinical and histopathological parameters on meeting the top selected criteria.RESULTS: The criteria with the highest sum score were negative soft tissue surgical margin, lymph node (LN) dissection of at least 16 LNs, no complications according to Clavien-Dindo grade 3-5 within 90 days after RC, treatment-free time between TUR-BT with detection of muscle-invasive UCB and RC <3 months and the absence of local UCB-recurrence in the pelvis ≤12 months. The first three criteria formed trifecta, and all five criteria pentafecta. A total of 334 patients qualified for final analysis, whereas 35.3 and 29 % met trifecta and pentafecta criteria, respectively. Multivariable analyses showed that the relative probability of meeting trifecta and pentafecta decreases with higher age (3.2 %, p = 0.043 and 3.3 %, p = 0.042) per year, respectively.CONCLUSIONS: Trifecta and pentafecta incorporate essential criteria in terms of outcome reporting and might be considered for the improvement of standardized quality assessment after RC for UCB.

AB - Radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB) is associated with heterogeneous functional and oncological outcomes. The aim of this study was to generate trifecta and pentafecta criteria to optimize outcome reporting after RC.METHODS: We interviewed 50 experts to consider a virtual group of patients (age ≤ 75 years, ASA score ≤ 3) undergoing RC for a cT2 UCB and a final histology of ≤pT3pN0M0. A ranking was generated for the three and five criteria with the highest sum score. The criteria were applied to the Prospective Multicenter Radical Cystectomy Series 2011. Multivariable binary logistic regression analyses were used to evaluate the impact of clinical and histopathological parameters on meeting the top selected criteria.RESULTS: The criteria with the highest sum score were negative soft tissue surgical margin, lymph node (LN) dissection of at least 16 LNs, no complications according to Clavien-Dindo grade 3-5 within 90 days after RC, treatment-free time between TUR-BT with detection of muscle-invasive UCB and RC <3 months and the absence of local UCB-recurrence in the pelvis ≤12 months. The first three criteria formed trifecta, and all five criteria pentafecta. A total of 334 patients qualified for final analysis, whereas 35.3 and 29 % met trifecta and pentafecta criteria, respectively. Multivariable analyses showed that the relative probability of meeting trifecta and pentafecta decreases with higher age (3.2 %, p = 0.043 and 3.3 %, p = 0.042) per year, respectively.CONCLUSIONS: Trifecta and pentafecta incorporate essential criteria in terms of outcome reporting and might be considered for the improvement of standardized quality assessment after RC for UCB.

U2 - 10.1007/s00345-015-1572-x

DO - 10.1007/s00345-015-1572-x

M3 - SCORING: Journal article

C2 - 25947885

VL - 33

SP - 1945

EP - 1950

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 12

ER -