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Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III

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Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III. / Bach, Thorsten; Bastian, Patrick J; Blana, Andreas; Kaminsky, Angelika; Keller, Stefan; Knoll, Thomas; Lang, Christoph; Promnitz, Soeren; Ubrig, Burkhard; Keller, Thomas; Qvick, Bryan; Burger, Maximilian; OPTIC III Study Group.

In: WORLD J UROL, Vol. 35, No. 5, 05.2017, p. 737-744.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bach, T, Bastian, PJ, Blana, A, Kaminsky, A, Keller, S, Knoll, T, Lang, C, Promnitz, S, Ubrig, B, Keller, T, Qvick, B, Burger, M & OPTIC III Study Group 2017, 'Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III', WORLD J UROL, vol. 35, no. 5, pp. 737-744. https://doi.org/10.1007/s00345-016-1925-0

APA

Bach, T., Bastian, P. J., Blana, A., Kaminsky, A., Keller, S., Knoll, T., Lang, C., Promnitz, S., Ubrig, B., Keller, T., Qvick, B., Burger, M., & OPTIC III Study Group (2017). Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III. WORLD J UROL, 35(5), 737-744. https://doi.org/10.1007/s00345-016-1925-0

Vancouver

Bach T, Bastian PJ, Blana A, Kaminsky A, Keller S, Knoll T et al. Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III. WORLD J UROL. 2017 May;35(5):737-744. https://doi.org/10.1007/s00345-016-1925-0

Bibtex

@article{241f8b66bdcd48f9a80ff5794fdc7f9c,
title = "Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III",
abstract = "PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix({\textregistered}), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use.METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone.RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed.CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS.",
author = "Thorsten Bach and Bastian, {Patrick J} and Andreas Blana and Angelika Kaminsky and Stefan Keller and Thomas Knoll and Christoph Lang and Soeren Promnitz and Burkhard Ubrig and Thomas Keller and Bryan Qvick and Maximilian Burger and {OPTIC III Study Group} and Michael Rink",
year = "2017",
month = may,
doi = "10.1007/s00345-016-1925-0",
language = "English",
volume = "35",
pages = "737--744",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Optimised photodynamic diagnosis for transurethral resection of the bladder (TURB) in German clinical practice: results of the noninterventional study OPTIC III

AU - Bach, Thorsten

AU - Bastian, Patrick J

AU - Blana, Andreas

AU - Kaminsky, Angelika

AU - Keller, Stefan

AU - Knoll, Thomas

AU - Lang, Christoph

AU - Promnitz, Soeren

AU - Ubrig, Burkhard

AU - Keller, Thomas

AU - Qvick, Bryan

AU - Burger, Maximilian

AU - OPTIC III Study Group

AU - Rink, Michael

PY - 2017/5

Y1 - 2017/5

N2 - PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use.METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone.RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed.CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS.

AB - PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use.METHODS: From May 2013 to April 2014, 403 patients with suspected NMIBC were screened from 30 German centres to perform an unprecedented detailed assessment of the additional detection of cancer lesions with HALC versus WLC alone.RESULTS: Among the histological results for 929 biopsy samples, 94.3 % were obtained from suspected cancerous lesions under either WLC or HALC: 59.5 % were carcinoma tissue and 40.5 % were non-cancerous tissue. Of all cancer lesions, 62.2 % were staged as Ta, 20.1 % as T1, 9.3 % as T2, 7.3 % as carcinoma in situ (CIS), and 1.2 % were unknown. Additional cancer lesions (+6.8 %) and CIS lesions (+25 %, p < 0.0001) were detected by HALC plus WLC versus WLC alone. In 10.0 % of patients, ≥1 additional positive lesion was detected with HALC, and 2.2 % of NMIBC patients would have been missed with WLC alone. No adverse events were observed.CONCLUSIONS: The results of this study demonstrate that HALC significantly improves the detection of NMIBC versus WLC alone in routine clinical practice in Germany. While this benefit is statistically significant across all types of NMIBC, it seems most relevant in CIS.

U2 - 10.1007/s00345-016-1925-0

DO - 10.1007/s00345-016-1925-0

M3 - SCORING: Journal article

C2 - 27578233

VL - 35

SP - 737

EP - 744

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 5

ER -