Research ExplorerPublicationsOptimal achieved blood pressure in acute intracerebral hemor...

Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2

Standard

Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2. / Arima, Hisatomi; Heeley, Emma; Delcourt, Candice; Hirakawa, Yoichiro; Wang, Xia; Woodward, Mark; Robinson, Thompson; Stapf, Christian; Parsons, Mark; Lavados, Pablo M; Huang, Yining; Wang, Jiguang; Chalmers, John; Anderson, Craig S; INTERACT2 investigators.

In: NEUROLOGY, Vol. 84, No. 5, 03.02.2015, p. 464-71.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Arima, H, Heeley, E, Delcourt, C, Hirakawa, Y, Wang, X, Woodward, M, Robinson, T, Stapf, C, Parsons, M, Lavados, PM, Huang, Y, Wang, J, Chalmers, J, Anderson, CS & INTERACT2 investigators 2015, 'Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2', NEUROLOGY, vol. 84, no. 5, pp. 464-71. https://doi.org/10.1212/WNL.0000000000001205

APA

Arima, H., Heeley, E., Delcourt, C., Hirakawa, Y., Wang, X., Woodward, M., Robinson, T., Stapf, C., Parsons, M., Lavados, P. M., Huang, Y., Wang, J., Chalmers, J., Anderson, C. S., & INTERACT2 investigators (2015). Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2. NEUROLOGY, 84(5), 464-71. https://doi.org/10.1212/WNL.0000000000001205

Vancouver

Arima H, Heeley E, Delcourt C, Hirakawa Y, Wang X, Woodward M et al. Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2. NEUROLOGY. 2015 Feb 3;84(5):464-71. https://doi.org/10.1212/WNL.0000000000001205

Bibtex

@article{02f60828aea24474a23f580dbed6052c,
title = "Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2",
abstract = "OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days.RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg.CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH.CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.",
author = "Hisatomi Arima and Emma Heeley and Candice Delcourt and Yoichiro Hirakawa and Xia Wang and Mark Woodward and Thompson Robinson and Christian Stapf and Mark Parsons and Lavados, {Pablo M} and Yining Huang and Jiguang Wang and John Chalmers and Anderson, {Craig S} and {INTERACT2 investigators} and G{\"o}tz Thomalla",
note = "{\textcopyright} 2014 American Academy of Neurology.",
year = "2015",
month = feb,
day = "3",
doi = "10.1212/WNL.0000000000001205",
language = "English",
volume = "84",
pages = "464--71",
journal = "NEUROLOGY",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2

AU - Arima, Hisatomi

AU - Heeley, Emma

AU - Delcourt, Candice

AU - Hirakawa, Yoichiro

AU - Wang, Xia

AU - Woodward, Mark

AU - Robinson, Thompson

AU - Stapf, Christian

AU - Parsons, Mark

AU - Lavados, Pablo M

AU - Huang, Yining

AU - Wang, Jiguang

AU - Chalmers, John

AU - Anderson, Craig S

AU - INTERACT2 investigators

AU - Thomalla, Götz

N1 - © 2014 American Academy of Neurology.

PY - 2015/2/3

Y1 - 2015/2/3

N2 - OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days.RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg.CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH.CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.

AB - OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days.RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg.CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH.CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.

U2 - 10.1212/WNL.0000000000001205

DO - 10.1212/WNL.0000000000001205

M3 - SCORING: Journal article

C2 - 25552575

VL - 84

SP - 464

EP - 471

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 5

ER -