Optical coherence tomography angiography analysis of macular flow density in glaucoma

Robert Kromer; Philipp Glusa; Carsten Framme; Amelie Pielen; Bernd Junker

doi:10.1111/aos.13914

Optical coherence tomography angiography analysis of macular flow density in glaucoma

Standard

Optical coherence tomography angiography analysis of macular flow density in glaucoma. / Kromer, Robert; Glusa, Philipp; Framme, Carsten; Pielen, Amelie; Junker, Bernd.

In: ACTA OPHTHALMOL, Vol. 97, No. 2, 03.2019, p. e199-e206.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kromer, R, Glusa, P, Framme, C, Pielen, A & Junker, B 2019, 'Optical coherence tomography angiography analysis of macular flow density in glaucoma', ACTA OPHTHALMOL, vol. 97, no. 2, pp. e199-e206. https://doi.org/10.1111/aos.13914

APA

Kromer, R., Glusa, P., Framme, C., Pielen, A., & Junker, B. (2019). Optical coherence tomography angiography analysis of macular flow density in glaucoma. ACTA OPHTHALMOL, 97(2), e199-e206. https://doi.org/10.1111/aos.13914

Vancouver

Kromer R, Glusa P, Framme C, Pielen A, Junker B. Optical coherence tomography angiography analysis of macular flow density in glaucoma. ACTA OPHTHALMOL. 2019 Mar;97(2):e199-e206. https://doi.org/10.1111/aos.13914

Bibtex

@article{1d414aa33da0463eab2991415036f7c3,

title = "Optical coherence tomography angiography analysis of macular flow density in glaucoma",

abstract = "PURPOSE: Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT-A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients.METHODS: Thirty patients with primary open-angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited. Patients received perimetry and OCT measurements of the peripapillary retinal nerve fibre layer thickness (RNFLT) and macular retinal thickness and OCT-A of the macular area in the superficial and deep retinal (DR) plexus. Flow density of the OCT-A scan was calculated by binarisation and quantification of the pixel density.RESULTS: Macular flow density was globally and nasally reduced in glaucoma patients in the superficial (globally: p = 0.0203; nasally: p = 0.0003) and DR plexus (globally: p = 0.0113, nasally: p < 0.0001). There was no significant difference between the superficial retina and the DR concerning the flow density. Flow density showed no significant correlation with perimetry results, RNFLT or retinal segment thickness.CONCLUSION: Patients with glaucoma exhibit a reduced macular flow density measured by OCT-A compared to controls. The independence of the macular flow density of the retinal segment thickness changes could indicate an altered vascular element in patients with glaucoma.",

keywords = "Aged, Blood Flow Velocity/physiology, Female, Fluorescein Angiography/methods, Follow-Up Studies, Fundus Oculi, Glaucoma, Open-Angle/diagnosis, Humans, Macula Lutea/blood supply, Male, Nerve Fibers/pathology, Optic Disk/pathology, Prospective Studies, Retinal Vessels/diagnostic imaging, Tomography, Optical Coherence/methods, Visual Field Tests, Visual Fields/physiology",

author = "Robert Kromer and Philipp Glusa and Carsten Framme and Amelie Pielen and Bernd Junker",

note = "{\textcopyright} 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",

year = "2019",

month = mar,

doi = "10.1111/aos.13914",

language = "English",

volume = "97",

pages = "e199--e206",

journal = "ACTA OPHTHALMOL",

issn = "1755-375X",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - Optical coherence tomography angiography analysis of macular flow density in glaucoma

AU - Kromer, Robert

AU - Glusa, Philipp

AU - Framme, Carsten

AU - Pielen, Amelie

AU - Junker, Bernd

PY - 2019/3

Y1 - 2019/3

N2 - PURPOSE: Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT-A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients.METHODS: Thirty patients with primary open-angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited. Patients received perimetry and OCT measurements of the peripapillary retinal nerve fibre layer thickness (RNFLT) and macular retinal thickness and OCT-A of the macular area in the superficial and deep retinal (DR) plexus. Flow density of the OCT-A scan was calculated by binarisation and quantification of the pixel density.RESULTS: Macular flow density was globally and nasally reduced in glaucoma patients in the superficial (globally: p = 0.0203; nasally: p = 0.0003) and DR plexus (globally: p = 0.0113, nasally: p < 0.0001). There was no significant difference between the superficial retina and the DR concerning the flow density. Flow density showed no significant correlation with perimetry results, RNFLT or retinal segment thickness.CONCLUSION: Patients with glaucoma exhibit a reduced macular flow density measured by OCT-A compared to controls. The independence of the macular flow density of the retinal segment thickness changes could indicate an altered vascular element in patients with glaucoma.

AB - PURPOSE: Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT-A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients.METHODS: Thirty patients with primary open-angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited. Patients received perimetry and OCT measurements of the peripapillary retinal nerve fibre layer thickness (RNFLT) and macular retinal thickness and OCT-A of the macular area in the superficial and deep retinal (DR) plexus. Flow density of the OCT-A scan was calculated by binarisation and quantification of the pixel density.RESULTS: Macular flow density was globally and nasally reduced in glaucoma patients in the superficial (globally: p = 0.0203; nasally: p = 0.0003) and DR plexus (globally: p = 0.0113, nasally: p < 0.0001). There was no significant difference between the superficial retina and the DR concerning the flow density. Flow density showed no significant correlation with perimetry results, RNFLT or retinal segment thickness.CONCLUSION: Patients with glaucoma exhibit a reduced macular flow density measured by OCT-A compared to controls. The independence of the macular flow density of the retinal segment thickness changes could indicate an altered vascular element in patients with glaucoma.

KW - Aged

KW - Blood Flow Velocity/physiology

KW - Female

KW - Fluorescein Angiography/methods

KW - Follow-Up Studies

KW - Fundus Oculi

KW - Glaucoma, Open-Angle/diagnosis

KW - Humans

KW - Macula Lutea/blood supply

KW - Male

KW - Nerve Fibers/pathology

KW - Optic Disk/pathology

KW - Prospective Studies

KW - Retinal Vessels/diagnostic imaging

KW - Tomography, Optical Coherence/methods

KW - Visual Field Tests

KW - Visual Fields/physiology

U2 - 10.1111/aos.13914

DO - 10.1111/aos.13914

M3 - SCORING: Journal article

C2 - 30178601

VL - 97

SP - e199-e206

JO - ACTA OPHTHALMOL

JF - ACTA OPHTHALMOL

SN - 1755-375X

IS - 2

ER -