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Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study

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Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study. / Sinnecker, Tim; Oberwahrenbrock, Timm; Metz, Imke; Zimmermann, Hanna; Pfueller, Caspar F; Harms, Lutz; Ruprecht, Klemens; Ramien, Caren; Hahn, Katrin; Brück, Wolfgang; Niendorf, Thoralf; Paul, Friedemann; Brandt, Alexander U; Dörr, Jan; Wuerfel, Jens.

In: EUR RADIOL, Vol. 25, No. 1, 01.2015, p. 122-31.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sinnecker, T, Oberwahrenbrock, T, Metz, I, Zimmermann, H, Pfueller, CF, Harms, L, Ruprecht, K, Ramien, C, Hahn, K, Brück, W, Niendorf, T, Paul, F, Brandt, AU, Dörr, J & Wuerfel, J 2015, 'Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study', EUR RADIOL, vol. 25, no. 1, pp. 122-31. https://doi.org/10.1007/s00330-014-3358-8

APA

Sinnecker, T., Oberwahrenbrock, T., Metz, I., Zimmermann, H., Pfueller, C. F., Harms, L., Ruprecht, K., Ramien, C., Hahn, K., Brück, W., Niendorf, T., Paul, F., Brandt, A. U., Dörr, J., & Wuerfel, J. (2015). Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study. EUR RADIOL, 25(1), 122-31. https://doi.org/10.1007/s00330-014-3358-8

Vancouver

Sinnecker T, Oberwahrenbrock T, Metz I, Zimmermann H, Pfueller CF, Harms L et al. Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study. EUR RADIOL. 2015 Jan;25(1):122-31. https://doi.org/10.1007/s00330-014-3358-8

Bibtex

@article{0873bb648ff24060a2e75cc1b46258b9,
title = "Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study",
abstract = "OBJECTIVE: To investigate posterior visual pathway damage in multiple sclerosis using ultrahigh-field magnetic resonance imaging (MRI) at 7 Tesla (7 T), and to determine its correlation with visual disability and retinal fibre layer (RNFL) damage detectable by optic coherence tomography (OCT).METHODS: We studied 7 T MRI, OCT, functional acuity contrast testing (FACT), and visually evoked potentials (VEP, n = 16) in 30 patients (including 26 relapsing-remitting MS and four clinically isolated syndrome patients) and 12 healthy controls to quantify RNFL thickness, optic radiation lesion volume, and optic radiation thickness.RESULTS: Optic radiation lesion volume was associated with thinning of the optic radiation (p < 0.001), delayed VEP (p = 0.031), and visual disability indicated by FACT (p = 0.020). Furthermore, we observed an inverse correlation between optic radiation lesion volume and RNFL thickness (p < 0.001), including patients without previous optic neuritis (p < 0.001).CONCLUSIONS: Anterior visual pathway damage, but also (subclinical) optic radiation integrity loss detectable by 7 T MRI are common findings in MS that are mutually affected. Given the association between optic radiation damage, visual impairment, and increased VEP latency in this exploratory study of a limited sample size, clinicians should be aware of acute lesions within the optic radiation in patients with (bilateral) visual disturbances.KEY POINTS: • Focal destruction of the optic radiation is detectable by 7 T MRI. • Focal optic radiation damage is common in MS. • Optic radiation damage is associated with RNFL thinning, detectable by OCT. • Optic radiation damage is associated with delayed VEP and visual dysfunction. • RNFL thickness in non-optic neuritis eyes correlates with optic radiation demyelination.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Evoked Potentials, Visual, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting/pathology, Nerve Fibers/pathology, Oculomotor Muscles/pathology, Optic Neuritis/pathology, Pilot Projects, Prospective Studies, Retinal Diseases/pathology, Tomography, Optical Coherence, Vision Disorders/etiology, Young Adult",
author = "Tim Sinnecker and Timm Oberwahrenbrock and Imke Metz and Hanna Zimmermann and Pfueller, {Caspar F} and Lutz Harms and Klemens Ruprecht and Caren Ramien and Katrin Hahn and Wolfgang Br{\"u}ck and Thoralf Niendorf and Friedemann Paul and Brandt, {Alexander U} and Jan D{\"o}rr and Jens Wuerfel",
year = "2015",
month = jan,
doi = "10.1007/s00330-014-3358-8",
language = "English",
volume = "25",
pages = "122--31",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study

AU - Sinnecker, Tim

AU - Oberwahrenbrock, Timm

AU - Metz, Imke

AU - Zimmermann, Hanna

AU - Pfueller, Caspar F

AU - Harms, Lutz

AU - Ruprecht, Klemens

AU - Ramien, Caren

AU - Hahn, Katrin

AU - Brück, Wolfgang

AU - Niendorf, Thoralf

AU - Paul, Friedemann

AU - Brandt, Alexander U

AU - Dörr, Jan

AU - Wuerfel, Jens

PY - 2015/1

Y1 - 2015/1

N2 - OBJECTIVE: To investigate posterior visual pathway damage in multiple sclerosis using ultrahigh-field magnetic resonance imaging (MRI) at 7 Tesla (7 T), and to determine its correlation with visual disability and retinal fibre layer (RNFL) damage detectable by optic coherence tomography (OCT).METHODS: We studied 7 T MRI, OCT, functional acuity contrast testing (FACT), and visually evoked potentials (VEP, n = 16) in 30 patients (including 26 relapsing-remitting MS and four clinically isolated syndrome patients) and 12 healthy controls to quantify RNFL thickness, optic radiation lesion volume, and optic radiation thickness.RESULTS: Optic radiation lesion volume was associated with thinning of the optic radiation (p < 0.001), delayed VEP (p = 0.031), and visual disability indicated by FACT (p = 0.020). Furthermore, we observed an inverse correlation between optic radiation lesion volume and RNFL thickness (p < 0.001), including patients without previous optic neuritis (p < 0.001).CONCLUSIONS: Anterior visual pathway damage, but also (subclinical) optic radiation integrity loss detectable by 7 T MRI are common findings in MS that are mutually affected. Given the association between optic radiation damage, visual impairment, and increased VEP latency in this exploratory study of a limited sample size, clinicians should be aware of acute lesions within the optic radiation in patients with (bilateral) visual disturbances.KEY POINTS: • Focal destruction of the optic radiation is detectable by 7 T MRI. • Focal optic radiation damage is common in MS. • Optic radiation damage is associated with RNFL thinning, detectable by OCT. • Optic radiation damage is associated with delayed VEP and visual dysfunction. • RNFL thickness in non-optic neuritis eyes correlates with optic radiation demyelination.

AB - OBJECTIVE: To investigate posterior visual pathway damage in multiple sclerosis using ultrahigh-field magnetic resonance imaging (MRI) at 7 Tesla (7 T), and to determine its correlation with visual disability and retinal fibre layer (RNFL) damage detectable by optic coherence tomography (OCT).METHODS: We studied 7 T MRI, OCT, functional acuity contrast testing (FACT), and visually evoked potentials (VEP, n = 16) in 30 patients (including 26 relapsing-remitting MS and four clinically isolated syndrome patients) and 12 healthy controls to quantify RNFL thickness, optic radiation lesion volume, and optic radiation thickness.RESULTS: Optic radiation lesion volume was associated with thinning of the optic radiation (p < 0.001), delayed VEP (p = 0.031), and visual disability indicated by FACT (p = 0.020). Furthermore, we observed an inverse correlation between optic radiation lesion volume and RNFL thickness (p < 0.001), including patients without previous optic neuritis (p < 0.001).CONCLUSIONS: Anterior visual pathway damage, but also (subclinical) optic radiation integrity loss detectable by 7 T MRI are common findings in MS that are mutually affected. Given the association between optic radiation damage, visual impairment, and increased VEP latency in this exploratory study of a limited sample size, clinicians should be aware of acute lesions within the optic radiation in patients with (bilateral) visual disturbances.KEY POINTS: • Focal destruction of the optic radiation is detectable by 7 T MRI. • Focal optic radiation damage is common in MS. • Optic radiation damage is associated with RNFL thinning, detectable by OCT. • Optic radiation damage is associated with delayed VEP and visual dysfunction. • RNFL thickness in non-optic neuritis eyes correlates with optic radiation demyelination.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Evoked Potentials, Visual

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Relapsing-Remitting/pathology

KW - Nerve Fibers/pathology

KW - Oculomotor Muscles/pathology

KW - Optic Neuritis/pathology

KW - Pilot Projects

KW - Prospective Studies

KW - Retinal Diseases/pathology

KW - Tomography, Optical Coherence

KW - Vision Disorders/etiology

KW - Young Adult

U2 - 10.1007/s00330-014-3358-8

DO - 10.1007/s00330-014-3358-8

M3 - SCORING: Journal article

C2 - 25129119

VL - 25

SP - 122

EP - 131

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 1

ER -