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Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO

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Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO. / Pölcher, Martin; Hauptmann, Steffen; Fotopoulou, Christina; Schmalfeldt, Barbara; Meinhold-Heerlein, Ivo; Mustea, Alexander; Runnebaum, Ingo; Sehouli, Jalid.

In: ARCH GYNECOL OBSTET, Vol. 292, No. 1, 07.2015, p. 231-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pölcher, M, Hauptmann, S, Fotopoulou, C, Schmalfeldt, B, Meinhold-Heerlein, I, Mustea, A, Runnebaum, I & Sehouli, J 2015, 'Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO', ARCH GYNECOL OBSTET, vol. 292, no. 1, pp. 231-4. https://doi.org/10.1007/s00404-015-3697-y

APA

Pölcher, M., Hauptmann, S., Fotopoulou, C., Schmalfeldt, B., Meinhold-Heerlein, I., Mustea, A., Runnebaum, I., & Sehouli, J. (2015). Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO. ARCH GYNECOL OBSTET, 292(1), 231-4. https://doi.org/10.1007/s00404-015-3697-y

Vancouver

Pölcher M, Hauptmann S, Fotopoulou C, Schmalfeldt B, Meinhold-Heerlein I, Mustea A et al. Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO. ARCH GYNECOL OBSTET. 2015 Jul;292(1):231-4. https://doi.org/10.1007/s00404-015-3697-y

Bibtex

@article{bc1d70e7fb9046a0b1c620fe726bc34d,
title = "Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO",
abstract = "The detection of premalignant cells in the epithelium of the fallopian tube has resulted in revolutionary theories regarding the origin of epithelial ovarian cancer (EOC). Serous tubal intra-epithelial carcinomas (STIC) have been detected in patients with BRCA 1 or 2 mutations and are considered as the most likely precursors of the high-grade serous ovarian cancer (HGSOC), which is the most common histological subtype in patients with EOC. A bilateral salpingo-oophorectomy is associated with a significant reduction in risk of developing EOC. According to various national guidelines, prophylactic bilateral salpingo-oophorectomy should be performed in the age group 40-45 years. As in patients with BRCA mutations, the prophylactic removal of the fallopian tubes is also performed in women without an increased genetic risk, for example, in surgical treatments of benign conditions. There is a current debate as to whether prophylactic or so-called opportunistic salpingectomy will influence the overall incidence of EOC in the coming years. Opponents of this theory warn of a higher surgical morbidity and the higher risk of a premature menopause through impaired vascular supply to the ovaries. The value of opportunistic salpingectomies has not yet been clarified since there are currently no systematic risk-benefit evaluations. This review will attempt to give an overview of the current body of evidence regarding the risks and benefits of opportunistic salpingectomies.",
keywords = "Adult, Carcinoma in Situ, Cystadenocarcinoma, Serous, Epithelium, Fallopian Tube Neoplasms, Fallopian Tubes, Female, Humans, Middle Aged, Mutation, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Ovariectomy, Salpingectomy",
author = "Martin P{\"o}lcher and Steffen Hauptmann and Christina Fotopoulou and Barbara Schmalfeldt and Ivo Meinhold-Heerlein and Alexander Mustea and Ingo Runnebaum and Jalid Sehouli",
year = "2015",
month = jul,
doi = "10.1007/s00404-015-3697-y",
language = "English",
volume = "292",
pages = "231--4",
journal = "ARCH GYNECOL OBSTET",
issn = "0932-0067",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Opportunistic salpingectomies for the prevention of a high-grade serous carcinoma: a statement by the Kommission Ovar of the AGO

AU - Pölcher, Martin

AU - Hauptmann, Steffen

AU - Fotopoulou, Christina

AU - Schmalfeldt, Barbara

AU - Meinhold-Heerlein, Ivo

AU - Mustea, Alexander

AU - Runnebaum, Ingo

AU - Sehouli, Jalid

PY - 2015/7

Y1 - 2015/7

N2 - The detection of premalignant cells in the epithelium of the fallopian tube has resulted in revolutionary theories regarding the origin of epithelial ovarian cancer (EOC). Serous tubal intra-epithelial carcinomas (STIC) have been detected in patients with BRCA 1 or 2 mutations and are considered as the most likely precursors of the high-grade serous ovarian cancer (HGSOC), which is the most common histological subtype in patients with EOC. A bilateral salpingo-oophorectomy is associated with a significant reduction in risk of developing EOC. According to various national guidelines, prophylactic bilateral salpingo-oophorectomy should be performed in the age group 40-45 years. As in patients with BRCA mutations, the prophylactic removal of the fallopian tubes is also performed in women without an increased genetic risk, for example, in surgical treatments of benign conditions. There is a current debate as to whether prophylactic or so-called opportunistic salpingectomy will influence the overall incidence of EOC in the coming years. Opponents of this theory warn of a higher surgical morbidity and the higher risk of a premature menopause through impaired vascular supply to the ovaries. The value of opportunistic salpingectomies has not yet been clarified since there are currently no systematic risk-benefit evaluations. This review will attempt to give an overview of the current body of evidence regarding the risks and benefits of opportunistic salpingectomies.

AB - The detection of premalignant cells in the epithelium of the fallopian tube has resulted in revolutionary theories regarding the origin of epithelial ovarian cancer (EOC). Serous tubal intra-epithelial carcinomas (STIC) have been detected in patients with BRCA 1 or 2 mutations and are considered as the most likely precursors of the high-grade serous ovarian cancer (HGSOC), which is the most common histological subtype in patients with EOC. A bilateral salpingo-oophorectomy is associated with a significant reduction in risk of developing EOC. According to various national guidelines, prophylactic bilateral salpingo-oophorectomy should be performed in the age group 40-45 years. As in patients with BRCA mutations, the prophylactic removal of the fallopian tubes is also performed in women without an increased genetic risk, for example, in surgical treatments of benign conditions. There is a current debate as to whether prophylactic or so-called opportunistic salpingectomy will influence the overall incidence of EOC in the coming years. Opponents of this theory warn of a higher surgical morbidity and the higher risk of a premature menopause through impaired vascular supply to the ovaries. The value of opportunistic salpingectomies has not yet been clarified since there are currently no systematic risk-benefit evaluations. This review will attempt to give an overview of the current body of evidence regarding the risks and benefits of opportunistic salpingectomies.

KW - Adult

KW - Carcinoma in Situ

KW - Cystadenocarcinoma, Serous

KW - Epithelium

KW - Fallopian Tube Neoplasms

KW - Fallopian Tubes

KW - Female

KW - Humans

KW - Middle Aged

KW - Mutation

KW - Neoplasms, Glandular and Epithelial

KW - Ovarian Neoplasms

KW - Ovariectomy

KW - Salpingectomy

U2 - 10.1007/s00404-015-3697-y

DO - 10.1007/s00404-015-3697-y

M3 - SCORING: Journal article

C2 - 25914073

VL - 292

SP - 231

EP - 234

JO - ARCH GYNECOL OBSTET

JF - ARCH GYNECOL OBSTET

SN - 0932-0067

IS - 1

ER -