[Opioids in anesthesia]
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[Opioids in anesthesia]. / Zöllner, Christian; Schäfer, M.
In: ANAESTHESIST, Vol. 57, No. 7, 7, 2008, p. 722-729.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - [Opioids in anesthesia]
AU - Zöllner, Christian
AU - Schäfer, M
PY - 2008
Y1 - 2008
N2 - Opioids are the most effective and widely used drugs in the treatment of severe acute and chronic pain. They act through opioid receptors that belong to the family of G protein-coupled receptors. Three classes of opioid receptors (mu, delta, kappa), expressed in the central and peripheral nervous system, have been identified. The analgesic effect of opioids is mediated through multiple pathways of opioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca(++) channel inhibition). The standard exogenous opioid analgesics used in the operating room are fentanyl, sufentanil, morphine, alfentanil, and remifentanil. Preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
AB - Opioids are the most effective and widely used drugs in the treatment of severe acute and chronic pain. They act through opioid receptors that belong to the family of G protein-coupled receptors. Three classes of opioid receptors (mu, delta, kappa), expressed in the central and peripheral nervous system, have been identified. The analgesic effect of opioids is mediated through multiple pathways of opioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca(++) channel inhibition). The standard exogenous opioid analgesics used in the operating room are fentanyl, sufentanil, morphine, alfentanil, and remifentanil. Preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
M3 - SCORING: Zeitschriftenaufsatz
VL - 57
SP - 722
EP - 729
JO - ANAESTHESIST
JF - ANAESTHESIST
SN - 0003-2417
IS - 7
M1 - 7
ER -
