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[One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]

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[One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]. / Tilki, D; Oliveira-Ferrer, Leticia; Kilic, Nerbil; Friedrich, Martin; Stief, C G; Ergun, S.

In: UROLOGE, Vol. 46, No. 9, 9, 2007, p. 1128-1134.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tilki, D, Oliveira-Ferrer, L, Kilic, N, Friedrich, M, Stief, CG & Ergun, S 2007, '[One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]', UROLOGE, vol. 46, no. 9, 9, pp. 1128-1134. <http://www.ncbi.nlm.nih.gov/pubmed/17605118?dopt=Citation>

APA

Tilki, D., Oliveira-Ferrer, L., Kilic, N., Friedrich, M., Stief, C. G., & Ergun, S. (2007). [One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]. UROLOGE, 46(9), 1128-1134. [9]. http://www.ncbi.nlm.nih.gov/pubmed/17605118?dopt=Citation

Vancouver

Tilki D, Oliveira-Ferrer L, Kilic N, Friedrich M, Stief CG, Ergun S. [One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]. UROLOGE. 2007;46(9):1128-1134. 9.

Bibtex

@article{1e3e8344bad84db8927e7ba1095ceabe,
title = "[One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]",
abstract = "BACKGROUND: Angiogenesis is a prerequisite for tumor growth and metastasis in which CEACAM1 plays an essential role. PATIENTS AND METHODS: The role of CEACAM1 in vascularization and invasion of prostate and bladder cancer was studied. RESULTS: Our analyses demonstrate an epithelial downregulation of CEACAM1 in superficial bladder tumors and in PIN of the prostate. Concurrently, CEACAM1 is upregulated in endothelial cells of tumor blood vessels. CEACAM1 knockdown in tumor cell lines of the prostate and urinary bladder via siRNA results in an increase of tumor vascularization while CEACAM1 overexpression in these cells suppresses it. CONCLUSIONS: CEACAM1-induced signaling mechanisms play a role in induction of angiogenesis in superficial tumors of the prostate and bladder. Strategies to either conserve the epithelial CEACAM1 or to target endothelial CEACAM1 might be useful for an antiangiogenic therapy of bladder and prostate cancer.",
author = "D Tilki and Leticia Oliveira-Ferrer and Nerbil Kilic and Martin Friedrich and Stief, {C G} and S Ergun",
year = "2007",
language = "Deutsch",
volume = "46",
pages = "1128--1134",
journal = "UROLOGE",
issn = "0340-2592",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - [One molecule, two faces. Epithelial loss of cell adhesion molecule CEACAM1 activates angiogenesis in bladder and prostate cancer]

AU - Tilki, D

AU - Oliveira-Ferrer, Leticia

AU - Kilic, Nerbil

AU - Friedrich, Martin

AU - Stief, C G

AU - Ergun, S

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Angiogenesis is a prerequisite for tumor growth and metastasis in which CEACAM1 plays an essential role. PATIENTS AND METHODS: The role of CEACAM1 in vascularization and invasion of prostate and bladder cancer was studied. RESULTS: Our analyses demonstrate an epithelial downregulation of CEACAM1 in superficial bladder tumors and in PIN of the prostate. Concurrently, CEACAM1 is upregulated in endothelial cells of tumor blood vessels. CEACAM1 knockdown in tumor cell lines of the prostate and urinary bladder via siRNA results in an increase of tumor vascularization while CEACAM1 overexpression in these cells suppresses it. CONCLUSIONS: CEACAM1-induced signaling mechanisms play a role in induction of angiogenesis in superficial tumors of the prostate and bladder. Strategies to either conserve the epithelial CEACAM1 or to target endothelial CEACAM1 might be useful for an antiangiogenic therapy of bladder and prostate cancer.

AB - BACKGROUND: Angiogenesis is a prerequisite for tumor growth and metastasis in which CEACAM1 plays an essential role. PATIENTS AND METHODS: The role of CEACAM1 in vascularization and invasion of prostate and bladder cancer was studied. RESULTS: Our analyses demonstrate an epithelial downregulation of CEACAM1 in superficial bladder tumors and in PIN of the prostate. Concurrently, CEACAM1 is upregulated in endothelial cells of tumor blood vessels. CEACAM1 knockdown in tumor cell lines of the prostate and urinary bladder via siRNA results in an increase of tumor vascularization while CEACAM1 overexpression in these cells suppresses it. CONCLUSIONS: CEACAM1-induced signaling mechanisms play a role in induction of angiogenesis in superficial tumors of the prostate and bladder. Strategies to either conserve the epithelial CEACAM1 or to target endothelial CEACAM1 might be useful for an antiangiogenic therapy of bladder and prostate cancer.

M3 - SCORING: Zeitschriftenaufsatz

VL - 46

SP - 1128

EP - 1134

JO - UROLOGE

JF - UROLOGE

SN - 0340-2592

IS - 9

M1 - 9

ER -