Research ExplorerPublicationsOncological outcome of primary versus secondary muscle-invas...

Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy

Standard

Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy. / Aziz, A; Gierth, M; Fritsche, H M; May, M; Otto, W; Denzinger, S; Wieland, W F; Merseburger, A; Riedmiller, H; Kocot, A; Burger, M.

In: UROL INT, Vol. 91, No. 1, 2013, p. 97-102.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Aziz, A, Gierth, M, Fritsche, HM, May, M, Otto, W, Denzinger, S, Wieland, WF, Merseburger, A, Riedmiller, H, Kocot, A & Burger, M 2013, 'Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy', UROL INT, vol. 91, no. 1, pp. 97-102. https://doi.org/10.1159/000350232

APA

Aziz, A., Gierth, M., Fritsche, H. M., May, M., Otto, W., Denzinger, S., Wieland, W. F., Merseburger, A., Riedmiller, H., Kocot, A., & Burger, M. (2013). Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy. UROL INT, 91(1), 97-102. https://doi.org/10.1159/000350232

Vancouver

Aziz A, Gierth M, Fritsche HM, May M, Otto W, Denzinger S et al. Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy. UROL INT. 2013;91(1):97-102. https://doi.org/10.1159/000350232

Bibtex

@article{10db21456a294c72b1e771e844d2f9c1,
title = "Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy",
abstract = "BACKGROUND: High-risk non-muscle-invasive bladder cancer (NMIBC) progressing to muscle-invasive bladder cancer (MIBC) is associated with adverse tumour biology. It is unclear, however, whether outcome of NMIBC progressing to MIBC is adverse compared to primary MIBC and whether NMIBC of higher risk of progression to MIBC is adverse compared to NMIBC of lower risk.OBJECTIVE: Our objective was to assess cancer-specific survival (CSS) following radical cystectomy (RC) for primary MIBC and for NMIBC progressing to MIBC in dependence of EORTC risk score.MATERIALS AND METHODS: Clinical and histopathological characteristics and CSS of 150 patients were assessed. Secondary MIBCs were stratified by EORTC risk score at the last transurethral resection of bladder tumour for NMIBC.RESULTS: CSS did not differ significantly between primary and secondary MIBC (p = 0.521). Secondary MIBC with high EORTC score had significantly shorter CSS compared to secondary MIBC with intermediate EORTC score (p = 0.029). In multivariable analysis, pathological tumour stage (HR = 3.77; p = 0.020) and lymph node stage (HR = 2.34; p = 0.022) were significantly correlated with CSS.CONCLUSION: While the outcome of secondary MIBC is not generally adverse compared to primary MIBC, the EORTC risk score not only reflects high risk of progression of NMIBC to MIBC, but also worse outcome following RC for secondary MIBC. Timely RC should thus be debated in high-risk NMIBC.",
keywords = "Aged, Cystectomy, Disease Progression, Female, Humans, Male, Middle Aged, Multivariate Analysis, Muscles, Neoplasm Invasiveness, Probability, Proportional Hazards Models, Risk, Time Factors, Treatment Outcome, Urinary Bladder Neoplasms, Journal Article",
author = "A Aziz and M Gierth and Fritsche, {H M} and M May and W Otto and S Denzinger and Wieland, {W F} and A Merseburger and H Riedmiller and A Kocot and M Burger",
note = "Copyright {\textcopyright} 2013 S. Karger AG, Basel.",
year = "2013",
doi = "10.1159/000350232",
language = "English",
volume = "91",
pages = "97--102",
journal = "UROL INT",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Oncological outcome of primary versus secondary muscle-invasive bladder cancer is comparable after radical cystectomy

AU - Aziz, A

AU - Gierth, M

AU - Fritsche, H M

AU - May, M

AU - Otto, W

AU - Denzinger, S

AU - Wieland, W F

AU - Merseburger, A

AU - Riedmiller, H

AU - Kocot, A

AU - Burger, M

N1 - Copyright © 2013 S. Karger AG, Basel.

PY - 2013

Y1 - 2013

N2 - BACKGROUND: High-risk non-muscle-invasive bladder cancer (NMIBC) progressing to muscle-invasive bladder cancer (MIBC) is associated with adverse tumour biology. It is unclear, however, whether outcome of NMIBC progressing to MIBC is adverse compared to primary MIBC and whether NMIBC of higher risk of progression to MIBC is adverse compared to NMIBC of lower risk.OBJECTIVE: Our objective was to assess cancer-specific survival (CSS) following radical cystectomy (RC) for primary MIBC and for NMIBC progressing to MIBC in dependence of EORTC risk score.MATERIALS AND METHODS: Clinical and histopathological characteristics and CSS of 150 patients were assessed. Secondary MIBCs were stratified by EORTC risk score at the last transurethral resection of bladder tumour for NMIBC.RESULTS: CSS did not differ significantly between primary and secondary MIBC (p = 0.521). Secondary MIBC with high EORTC score had significantly shorter CSS compared to secondary MIBC with intermediate EORTC score (p = 0.029). In multivariable analysis, pathological tumour stage (HR = 3.77; p = 0.020) and lymph node stage (HR = 2.34; p = 0.022) were significantly correlated with CSS.CONCLUSION: While the outcome of secondary MIBC is not generally adverse compared to primary MIBC, the EORTC risk score not only reflects high risk of progression of NMIBC to MIBC, but also worse outcome following RC for secondary MIBC. Timely RC should thus be debated in high-risk NMIBC.

AB - BACKGROUND: High-risk non-muscle-invasive bladder cancer (NMIBC) progressing to muscle-invasive bladder cancer (MIBC) is associated with adverse tumour biology. It is unclear, however, whether outcome of NMIBC progressing to MIBC is adverse compared to primary MIBC and whether NMIBC of higher risk of progression to MIBC is adverse compared to NMIBC of lower risk.OBJECTIVE: Our objective was to assess cancer-specific survival (CSS) following radical cystectomy (RC) for primary MIBC and for NMIBC progressing to MIBC in dependence of EORTC risk score.MATERIALS AND METHODS: Clinical and histopathological characteristics and CSS of 150 patients were assessed. Secondary MIBCs were stratified by EORTC risk score at the last transurethral resection of bladder tumour for NMIBC.RESULTS: CSS did not differ significantly between primary and secondary MIBC (p = 0.521). Secondary MIBC with high EORTC score had significantly shorter CSS compared to secondary MIBC with intermediate EORTC score (p = 0.029). In multivariable analysis, pathological tumour stage (HR = 3.77; p = 0.020) and lymph node stage (HR = 2.34; p = 0.022) were significantly correlated with CSS.CONCLUSION: While the outcome of secondary MIBC is not generally adverse compared to primary MIBC, the EORTC risk score not only reflects high risk of progression of NMIBC to MIBC, but also worse outcome following RC for secondary MIBC. Timely RC should thus be debated in high-risk NMIBC.

KW - Aged

KW - Cystectomy

KW - Disease Progression

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Muscles

KW - Neoplasm Invasiveness

KW - Probability

KW - Proportional Hazards Models

KW - Risk

KW - Time Factors

KW - Treatment Outcome

KW - Urinary Bladder Neoplasms

KW - Journal Article

U2 - 10.1159/000350232

DO - 10.1159/000350232

M3 - SCORING: Journal article

C2 - 23751372

VL - 91

SP - 97

EP - 102

JO - UROL INT

JF - UROL INT

SN - 0042-1138

IS - 1

ER -