Research ExplorerPublicationsOff-Hour Admission and Outcomes in Patients with Acute Intra...

Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial

Standard

Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial. / Sato, Shoichiro; Arima, Hisatomi; Heeley, Emma; Hirakawa, Yoichiro; Delcourt, Candice; Lindley, Richard I; Robinson, Thompson; Huang, Yining; Morgenstern, Lewis; Stapf, Christian; Wang, Jiguang; Chalmers, John; Anderson, Craig S; INTERACT2 investigators.

In: CEREBROVASC DIS, Vol. 40, No. 3-4, 2015, p. 114-20.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sato, S, Arima, H, Heeley, E, Hirakawa, Y, Delcourt, C, Lindley, RI, Robinson, T, Huang, Y, Morgenstern, L, Stapf, C, Wang, J, Chalmers, J, Anderson, CS & INTERACT2 investigators 2015, 'Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial', CEREBROVASC DIS, vol. 40, no. 3-4, pp. 114-20. https://doi.org/10.1159/000434690

APA

Sato, S., Arima, H., Heeley, E., Hirakawa, Y., Delcourt, C., Lindley, R. I., Robinson, T., Huang, Y., Morgenstern, L., Stapf, C., Wang, J., Chalmers, J., Anderson, C. S., & INTERACT2 investigators (2015). Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial. CEREBROVASC DIS, 40(3-4), 114-20. https://doi.org/10.1159/000434690

Vancouver

Sato S, Arima H, Heeley E, Hirakawa Y, Delcourt C, Lindley RI et al. Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial. CEREBROVASC DIS. 2015;40(3-4):114-20. https://doi.org/10.1159/000434690

Bibtex

@article{5b31d22cd8cd40f780d40ada109c06b4,
title = "Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial",
abstract = "BACKGROUND: Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off- and on-hour admissions, among participants of the Intensive BP Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).METHODS: Subsidiary analysis of INTERACT2, a multinational, multicenter, clinical trial of patients with spontaneous ICH with elevated systolic BP, randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Primary outcome was death or major disability (modified Rankin scale of 3-6) at 90 days. Off-hour admission was defined as night-time (4:30 p.m. to 8:30 a.m.) on weekdays, weekends (Saturday and Sunday), and public holidays in each participating country.RESULTS: Of 2,794 patients with information on the primary outcome, 1,770 (63%) were admitted to study centers during off-hours. Off-hour admission was not associated with risk of poor outcome at 90 days (53% off-hour vs. 55% on-hour; p = 0.49), even after adjustment for comorbid risk factors (odds ratio 0.92; 95% CI 0.76-1.12). Consistency exists in the effects of intensive BP lowering between off- and on-hour admission (p = 0.85 for homogeneity).CONCLUSIONS: Off-hour admission was not associated with increased risks of death or major disability among trial protocol participants with acute ICH. Intensive BP lowering can provide similar treatment effect irrespective of admission hours.",
author = "Shoichiro Sato and Hisatomi Arima and Emma Heeley and Yoichiro Hirakawa and Candice Delcourt and Lindley, {Richard I} and Thompson Robinson and Yining Huang and Lewis Morgenstern and Christian Stapf and Jiguang Wang and John Chalmers and Anderson, {Craig S} and {INTERACT2 investigators} and G{\"o}tz Thomalla",
note = "{\textcopyright} 2015 S. Karger AG, Basel.",
year = "2015",
doi = "10.1159/000434690",
language = "English",
volume = "40",
pages = "114--20",
journal = "CEREBROVASC DIS",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "3-4",

}

RIS

TY - JOUR

T1 - Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial

AU - Sato, Shoichiro

AU - Arima, Hisatomi

AU - Heeley, Emma

AU - Hirakawa, Yoichiro

AU - Delcourt, Candice

AU - Lindley, Richard I

AU - Robinson, Thompson

AU - Huang, Yining

AU - Morgenstern, Lewis

AU - Stapf, Christian

AU - Wang, Jiguang

AU - Chalmers, John

AU - Anderson, Craig S

AU - INTERACT2 investigators

AU - Thomalla, Götz

N1 - © 2015 S. Karger AG, Basel.

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off- and on-hour admissions, among participants of the Intensive BP Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).METHODS: Subsidiary analysis of INTERACT2, a multinational, multicenter, clinical trial of patients with spontaneous ICH with elevated systolic BP, randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Primary outcome was death or major disability (modified Rankin scale of 3-6) at 90 days. Off-hour admission was defined as night-time (4:30 p.m. to 8:30 a.m.) on weekdays, weekends (Saturday and Sunday), and public holidays in each participating country.RESULTS: Of 2,794 patients with information on the primary outcome, 1,770 (63%) were admitted to study centers during off-hours. Off-hour admission was not associated with risk of poor outcome at 90 days (53% off-hour vs. 55% on-hour; p = 0.49), even after adjustment for comorbid risk factors (odds ratio 0.92; 95% CI 0.76-1.12). Consistency exists in the effects of intensive BP lowering between off- and on-hour admission (p = 0.85 for homogeneity).CONCLUSIONS: Off-hour admission was not associated with increased risks of death or major disability among trial protocol participants with acute ICH. Intensive BP lowering can provide similar treatment effect irrespective of admission hours.

AB - BACKGROUND: Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off- and on-hour admissions, among participants of the Intensive BP Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).METHODS: Subsidiary analysis of INTERACT2, a multinational, multicenter, clinical trial of patients with spontaneous ICH with elevated systolic BP, randomly assigned to intensive (target systolic BP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Primary outcome was death or major disability (modified Rankin scale of 3-6) at 90 days. Off-hour admission was defined as night-time (4:30 p.m. to 8:30 a.m.) on weekdays, weekends (Saturday and Sunday), and public holidays in each participating country.RESULTS: Of 2,794 patients with information on the primary outcome, 1,770 (63%) were admitted to study centers during off-hours. Off-hour admission was not associated with risk of poor outcome at 90 days (53% off-hour vs. 55% on-hour; p = 0.49), even after adjustment for comorbid risk factors (odds ratio 0.92; 95% CI 0.76-1.12). Consistency exists in the effects of intensive BP lowering between off- and on-hour admission (p = 0.85 for homogeneity).CONCLUSIONS: Off-hour admission was not associated with increased risks of death or major disability among trial protocol participants with acute ICH. Intensive BP lowering can provide similar treatment effect irrespective of admission hours.

U2 - 10.1159/000434690

DO - 10.1159/000434690

M3 - SCORING: Journal article

C2 - 26202097

VL - 40

SP - 114

EP - 120

JO - CEREBROVASC DIS

JF - CEREBROVASC DIS

SN - 1015-9770

IS - 3-4

ER -