Occurrence of papillomavirus structural antigens in oral papillomas and leukoplakias.
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Occurrence of papillomavirus structural antigens in oral papillomas and leukoplakias. / Löning, Thomas; Reichart, P; Staquet, M J; Becker, J; Thivolet, J.
In: J Oral Pathol, Vol. 13, No. 2, 2, 1984, p. 155-165.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Occurrence of papillomavirus structural antigens in oral papillomas and leukoplakias.
AU - Löning, Thomas
AU - Reichart, P
AU - Staquet, M J
AU - Becker, J
AU - Thivolet, J
PY - 1984
Y1 - 1984
N2 - Six oral papillomas and 7 oral leukoplakias were studied with genus-specific antibodies against detergent-disrupted papillomaviruses. Indirect immunofluorescence staining was applied to frozen sections. Distinct nuclear staining of superficial keratinocytes was seen in 5 of 6 oral papillomas, 2 of 5 homogenous leukoplakias, and in 2 cases of nodular leukoplakia, one of these showing transition into an invasive carcinoma. Papillomavirus antibodies offer a new way to detect and localize papillomaviruses in epithelial hyperplasias. The relevance of the immunomorphological identification of papillomavirus-associated antigens is discussed with special reference to the molecular hybridization technique.
AB - Six oral papillomas and 7 oral leukoplakias were studied with genus-specific antibodies against detergent-disrupted papillomaviruses. Indirect immunofluorescence staining was applied to frozen sections. Distinct nuclear staining of superficial keratinocytes was seen in 5 of 6 oral papillomas, 2 of 5 homogenous leukoplakias, and in 2 cases of nodular leukoplakia, one of these showing transition into an invasive carcinoma. Papillomavirus antibodies offer a new way to detect and localize papillomaviruses in epithelial hyperplasias. The relevance of the immunomorphological identification of papillomavirus-associated antigens is discussed with special reference to the molecular hybridization technique.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 155
EP - 165
IS - 2
M1 - 2
ER -