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Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function

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Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function. / Zink, M; Schirmbeck, F; Rausch, F; Eifler, S; Elkin, H; Solojenkina, X; Englisch, S; Wagner, M; Maier, W; Lautenschlager, M; Heinz, A; Gudlowski, Y; Janssen, B; Gaebel, W; Michel, T M; Schneider, F; Lambert, M; Naber, D; Juckel, G; Krueger-Oezguerdal, S; Wobrock, T; Hasan, A; Riedel, M; Müller, H; Klosterkötter, J; Bechdolf, A.

In: ACTA PSYCHIAT SCAND, Vol. 130, No. 3, 01.09.2014, p. 214-226.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zink, M, Schirmbeck, F, Rausch, F, Eifler, S, Elkin, H, Solojenkina, X, Englisch, S, Wagner, M, Maier, W, Lautenschlager, M, Heinz, A, Gudlowski, Y, Janssen, B, Gaebel, W, Michel, TM, Schneider, F, Lambert, M, Naber, D, Juckel, G, Krueger-Oezguerdal, S, Wobrock, T, Hasan, A, Riedel, M, Müller, H, Klosterkötter, J & Bechdolf, A 2014, 'Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function', ACTA PSYCHIAT SCAND, vol. 130, no. 3, pp. 214-226. https://doi.org/10.1111/acps.12258

APA

Zink, M., Schirmbeck, F., Rausch, F., Eifler, S., Elkin, H., Solojenkina, X., Englisch, S., Wagner, M., Maier, W., Lautenschlager, M., Heinz, A., Gudlowski, Y., Janssen, B., Gaebel, W., Michel, T. M., Schneider, F., Lambert, M., Naber, D., Juckel, G., ... Bechdolf, A. (2014). Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function. ACTA PSYCHIAT SCAND, 130(3), 214-226. https://doi.org/10.1111/acps.12258

Vancouver

Zink M, Schirmbeck F, Rausch F, Eifler S, Elkin H, Solojenkina X et al. Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function. ACTA PSYCHIAT SCAND. 2014 Sep 1;130(3):214-226. https://doi.org/10.1111/acps.12258

Bibtex

@article{a0bc6b7549254462986d13bcaddaa9af,
title = "Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function",
abstract = "OBJECTIVE: Obsessive-compulsive symptoms (OCS) constitute a major comorbidity in schizophrenia. Prevalence estimations of OCS for patients with at-risk mental states (ARMS) for psychosis vary largely. It is unclear how ARMS patients with or without comorbid OCS differ regarding general psychosocial functioning, psychotic and affective symptoms and neurocognitive abilities.METHOD: At-risk mental states patients (n = 233) from the interventional trial PREVENT (Secondary Prevention of Schizophrenia) were stratified according to the presence or absence of comorbid OCS and compared on several clinical variables.RESULTS: Patients, who fulfilled the criteria for obsessive-compulsive disorder (OCD) or presented with subclinical OCS (ARMSposOCS sample), did not significantly differ from patients without OCS (ARMSnegOCS) with regard to gender, age, premorbid verbal intelligence and levels of education. Furthermore, similar severity of depressive syndromes, basic cognitive, attenuated psychotic and brief limited intermittent psychotic symptoms were found. However, ARMSposOCS patients showed more impairment of psychosocial functioning and higher general psychopathology. In contrast, they scored higher in cognitive tasks measuring working memory and immediate verbal memory.CONCLUSION: Findings extend upon previous results due to the multidimensional assessment. Subsequent longitudinal studies might elucidate how comorbid OCS influence differential treatment response, especially to cognitive behavioural interventions and the transition rates to psychosis.",
author = "M Zink and F Schirmbeck and F Rausch and S Eifler and H Elkin and X Solojenkina and S Englisch and M Wagner and W Maier and M Lautenschlager and A Heinz and Y Gudlowski and B Janssen and W Gaebel and Michel, {T M} and F Schneider and M Lambert and D Naber and G Juckel and S Krueger-Oezguerdal and T Wobrock and A Hasan and M Riedel and H M{\"u}ller and J Klosterk{\"o}tter and A Bechdolf",
note = "{\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2014",
month = sep,
day = "1",
doi = "10.1111/acps.12258",
language = "English",
volume = "130",
pages = "214--226",
journal = "ACTA PSYCHIAT SCAND",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Obsessive-compulsive symptoms in at-risk mental states for psychosis: associations with clinical impairment and cognitive function

AU - Zink, M

AU - Schirmbeck, F

AU - Rausch, F

AU - Eifler, S

AU - Elkin, H

AU - Solojenkina, X

AU - Englisch, S

AU - Wagner, M

AU - Maier, W

AU - Lautenschlager, M

AU - Heinz, A

AU - Gudlowski, Y

AU - Janssen, B

AU - Gaebel, W

AU - Michel, T M

AU - Schneider, F

AU - Lambert, M

AU - Naber, D

AU - Juckel, G

AU - Krueger-Oezguerdal, S

AU - Wobrock, T

AU - Hasan, A

AU - Riedel, M

AU - Müller, H

AU - Klosterkötter, J

AU - Bechdolf, A

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - OBJECTIVE: Obsessive-compulsive symptoms (OCS) constitute a major comorbidity in schizophrenia. Prevalence estimations of OCS for patients with at-risk mental states (ARMS) for psychosis vary largely. It is unclear how ARMS patients with or without comorbid OCS differ regarding general psychosocial functioning, psychotic and affective symptoms and neurocognitive abilities.METHOD: At-risk mental states patients (n = 233) from the interventional trial PREVENT (Secondary Prevention of Schizophrenia) were stratified according to the presence or absence of comorbid OCS and compared on several clinical variables.RESULTS: Patients, who fulfilled the criteria for obsessive-compulsive disorder (OCD) or presented with subclinical OCS (ARMSposOCS sample), did not significantly differ from patients without OCS (ARMSnegOCS) with regard to gender, age, premorbid verbal intelligence and levels of education. Furthermore, similar severity of depressive syndromes, basic cognitive, attenuated psychotic and brief limited intermittent psychotic symptoms were found. However, ARMSposOCS patients showed more impairment of psychosocial functioning and higher general psychopathology. In contrast, they scored higher in cognitive tasks measuring working memory and immediate verbal memory.CONCLUSION: Findings extend upon previous results due to the multidimensional assessment. Subsequent longitudinal studies might elucidate how comorbid OCS influence differential treatment response, especially to cognitive behavioural interventions and the transition rates to psychosis.

AB - OBJECTIVE: Obsessive-compulsive symptoms (OCS) constitute a major comorbidity in schizophrenia. Prevalence estimations of OCS for patients with at-risk mental states (ARMS) for psychosis vary largely. It is unclear how ARMS patients with or without comorbid OCS differ regarding general psychosocial functioning, psychotic and affective symptoms and neurocognitive abilities.METHOD: At-risk mental states patients (n = 233) from the interventional trial PREVENT (Secondary Prevention of Schizophrenia) were stratified according to the presence or absence of comorbid OCS and compared on several clinical variables.RESULTS: Patients, who fulfilled the criteria for obsessive-compulsive disorder (OCD) or presented with subclinical OCS (ARMSposOCS sample), did not significantly differ from patients without OCS (ARMSnegOCS) with regard to gender, age, premorbid verbal intelligence and levels of education. Furthermore, similar severity of depressive syndromes, basic cognitive, attenuated psychotic and brief limited intermittent psychotic symptoms were found. However, ARMSposOCS patients showed more impairment of psychosocial functioning and higher general psychopathology. In contrast, they scored higher in cognitive tasks measuring working memory and immediate verbal memory.CONCLUSION: Findings extend upon previous results due to the multidimensional assessment. Subsequent longitudinal studies might elucidate how comorbid OCS influence differential treatment response, especially to cognitive behavioural interventions and the transition rates to psychosis.

U2 - 10.1111/acps.12258

DO - 10.1111/acps.12258

M3 - SCORING: Journal article

C2 - 24571191

VL - 130

SP - 214

EP - 226

JO - ACTA PSYCHIAT SCAND

JF - ACTA PSYCHIAT SCAND

SN - 0001-690X

IS - 3

ER -