Obesity management: sex-specific considerations
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Obesity management: sex-specific considerations. / Kantowski, Tobias; Schulze Zur Wiesch, Clarissa; Aberle, Jens; Lautenbach, Anne.
In: ARCH GYNECOL OBSTET, Vol. 309, No. 5, 05.2024, p. 1745-1752.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Obesity management: sex-specific considerations
AU - Kantowski, Tobias
AU - Schulze Zur Wiesch, Clarissa
AU - Aberle, Jens
AU - Lautenbach, Anne
N1 - © 2024. The Author(s).
PY - 2024/5
Y1 - 2024/5
N2 - Obesity is a global health issue that has grown to epidemic proportions. According to World Health Organisation (WHO), overweight and obesity are responsible for more than 1.2 million deaths in Europe each year, representing > 13% of the region's total mortality. Highly processed, calorie-dense foods and reduced physical activity are considered as primary drivers of obesity, but genetic predisposition also plays a significant role. Notably, obesity is more prevalent in women than in men in most countries, and several obesity-related comorbidities exhibit sex-specific pathways. Treatment indication depends on BMI (body mass index), as well as existing comorbidities and risk factors. To reduce obesity-associated comorbidities, a permanent reduction in body weight of (at least) 5-10% is recommended. Treatment guidelines suggest an escalating stepwise approach including lifestyle intervention, pharmacotherapy, and bariatric-metabolic surgery. As cumulative evidence suggests differences in weight loss outcomes, there is growing interest in sex-specific considerations in obesity management. However, most trials do not report weight loss or changes in body composition separately for women and men. Here, we discuss state-of-the-art obesity management and focus on current data about the impact of sex on weight loss outcomes.
AB - Obesity is a global health issue that has grown to epidemic proportions. According to World Health Organisation (WHO), overweight and obesity are responsible for more than 1.2 million deaths in Europe each year, representing > 13% of the region's total mortality. Highly processed, calorie-dense foods and reduced physical activity are considered as primary drivers of obesity, but genetic predisposition also plays a significant role. Notably, obesity is more prevalent in women than in men in most countries, and several obesity-related comorbidities exhibit sex-specific pathways. Treatment indication depends on BMI (body mass index), as well as existing comorbidities and risk factors. To reduce obesity-associated comorbidities, a permanent reduction in body weight of (at least) 5-10% is recommended. Treatment guidelines suggest an escalating stepwise approach including lifestyle intervention, pharmacotherapy, and bariatric-metabolic surgery. As cumulative evidence suggests differences in weight loss outcomes, there is growing interest in sex-specific considerations in obesity management. However, most trials do not report weight loss or changes in body composition separately for women and men. Here, we discuss state-of-the-art obesity management and focus on current data about the impact of sex on weight loss outcomes.
U2 - 10.1007/s00404-023-07367-0
DO - 10.1007/s00404-023-07367-0
M3 - SCORING: Review article
C2 - 38329549
VL - 309
SP - 1745
EP - 1752
JO - ARCH GYNECOL OBSTET
JF - ARCH GYNECOL OBSTET
SN - 0932-0067
IS - 5
ER -