O2-Utilisation während und nach hyperthermer Extremitätenperfusion mit rhTNF alpha und Melphalan
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O2-Utilisation während und nach hyperthermer Extremitätenperfusion mit rhTNF alpha und Melphalan. / Haier, J; Hohenberger, P; Beck, K; Schlag, P M.
In: LANGENBECK ARCH SURG, Vol. 382, No. 3, 1997, p. 128-33.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - O2-Utilisation während und nach hyperthermer Extremitätenperfusion mit rhTNF alpha und Melphalan
AU - Haier, J
AU - Hohenberger, P
AU - Beck, K
AU - Schlag, P M
PY - 1997
Y1 - 1997
N2 - During isolated limb perfusion (ILP) severe metabolic impairment with a subsequent alteration in oxygen consumption can be observed. The mechanisms responsible for this may be extracorporeal circulation, hyperthermia, and application of cytostatic drugs and cytokines. Thirty-three patients underwent ILP with rhTNF alpha and melphalan for melanoma or soft-tissue sarcoma. Cardiopulmonary monitoring consisted of arterial and mixed venous blood-gas analysis and a Swan-Ganz catheter was inserted after induction of general anesthesia prior to any surgical intervention. Arterial (SaO2) and mixed venous (SvO2) oxygen saturation, serum lactate and end-expiratory CO2 concentration were determined peri- and postoperatively for 72 h. Oxygen supply and consumption rates were measured systemically (DO2I, VO2I) and in the extracorporeal circuit ('DO2I, 'VO2I). For statistical analysis we used the t-test. During extracorporal circulation an increase of DO2I and VO2I was observed. A slight increase of lactate values began during the wash-out phase. Immediately after reperfusion. DO2I, VO2I and lactate increased significantly with normalization until the 2nd postoperative day. SaO2 and SvO2 remained unchanged. A significant correlation between regional toxicity and the postoperative maximum of serum lactate values was found. The increase of DO2I and VO2I in the tissues during ILP and after reperfusion was achieved by a significant increase in cardiac output while the oxygen extraction rate was not altered. Elevation of lactate values after reperfusion and the increase in oxygen utilization might be due to oxygen depletion in the perfused limb. This could contribute to the development of lactacidosis or rhabdomyolysis. Therefore, to minimize toxicity it seems to be mandatory to measure adequate tissue oxygen supply during ILP.
AB - During isolated limb perfusion (ILP) severe metabolic impairment with a subsequent alteration in oxygen consumption can be observed. The mechanisms responsible for this may be extracorporeal circulation, hyperthermia, and application of cytostatic drugs and cytokines. Thirty-three patients underwent ILP with rhTNF alpha and melphalan for melanoma or soft-tissue sarcoma. Cardiopulmonary monitoring consisted of arterial and mixed venous blood-gas analysis and a Swan-Ganz catheter was inserted after induction of general anesthesia prior to any surgical intervention. Arterial (SaO2) and mixed venous (SvO2) oxygen saturation, serum lactate and end-expiratory CO2 concentration were determined peri- and postoperatively for 72 h. Oxygen supply and consumption rates were measured systemically (DO2I, VO2I) and in the extracorporeal circuit ('DO2I, 'VO2I). For statistical analysis we used the t-test. During extracorporal circulation an increase of DO2I and VO2I was observed. A slight increase of lactate values began during the wash-out phase. Immediately after reperfusion. DO2I, VO2I and lactate increased significantly with normalization until the 2nd postoperative day. SaO2 and SvO2 remained unchanged. A significant correlation between regional toxicity and the postoperative maximum of serum lactate values was found. The increase of DO2I and VO2I in the tissues during ILP and after reperfusion was achieved by a significant increase in cardiac output while the oxygen extraction rate was not altered. Elevation of lactate values after reperfusion and the increase in oxygen utilization might be due to oxygen depletion in the perfused limb. This could contribute to the development of lactacidosis or rhabdomyolysis. Therefore, to minimize toxicity it seems to be mandatory to measure adequate tissue oxygen supply during ILP.
KW - Adolescent
KW - Adult
KW - Aged
KW - Antineoplastic Agents, Alkylating
KW - Carbon Dioxide
KW - Chemotherapy, Cancer, Regional Perfusion
KW - Combined Modality Therapy
KW - Extremities
KW - Female
KW - Humans
KW - Hyperthermia, Induced
KW - Lactic Acid
KW - Male
KW - Melanoma
KW - Melphalan
KW - Middle Aged
KW - Oxygen
KW - Oxygen Consumption
KW - Reperfusion Injury
KW - Sarcoma
KW - Skin Neoplasms
KW - Soft Tissue Neoplasms
KW - Treatment Outcome
KW - Tumor Necrosis Factor-alpha
M3 - SCORING: Zeitschriftenaufsatz
C2 - 9324610
VL - 382
SP - 128
EP - 133
JO - LANGENBECK ARCH SURG
JF - LANGENBECK ARCH SURG
SN - 1435-2443
IS - 3
ER -