NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up
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NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up. / Tynkkynen, Juho; Laatikainen, Tiina; Salomaa, Veikko; Havulinna, Aki S; Blankenberg, Stefan; Zeller, Tanja; Hernesniemi, Jussi A.
In: J ALZHEIMERS DIS, Vol. 44, No. 3, 2015, p. 1007-1013.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up
AU - Tynkkynen, Juho
AU - Laatikainen, Tiina
AU - Salomaa, Veikko
AU - Havulinna, Aki S
AU - Blankenberg, Stefan
AU - Zeller, Tanja
AU - Hernesniemi, Jussi A
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Memory disorders and Alzheimer's disease (AD) share the same risk factors with cardiovascular diseases.OBJECTIVE: We tested whether elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels would predict any incident dementia or AD.METHODS: The association between NT-proBNP and the risk of dementia was evaluated in a total of 7,158 subjects without previous memory disorders in a prospective study with a median follow-up of 13.8 years.RESULTS: A total of 220 new dementia cases occurred, of which 149 were AD. Baseline logNT-proBNP levels were associated significantly with the risk of dementia in the entire study population (HR 1.32, 95%CI 1.17-1.56, p = 0.001) per 1SD difference, adjusted for multiple cardiovascular risk factors. Integrated discrimination improvement (IDI) and continuous net-reclassification improvement (continuous NRI) were improved in the study population over 40 years of age: continuous NRI was 17.5% (95%CI 4.4-30.6%, p = 0.009) and IDI was 0.005 (95%CI 0.001-0.010, p = 0.021). Regarding AD, the HR for 1SD logNT-proBNP change was 1.23 (95%CI 1.01-1.49, p = 0.040) in the entire study population, but no IDI or continuous NRI improvement was seen.CONCLUSION: NT-proBNP is also an independent risk marker for dementia, and patient discrimination regarding dementia risk could be improved by using it.
AB - BACKGROUND: Memory disorders and Alzheimer's disease (AD) share the same risk factors with cardiovascular diseases.OBJECTIVE: We tested whether elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels would predict any incident dementia or AD.METHODS: The association between NT-proBNP and the risk of dementia was evaluated in a total of 7,158 subjects without previous memory disorders in a prospective study with a median follow-up of 13.8 years.RESULTS: A total of 220 new dementia cases occurred, of which 149 were AD. Baseline logNT-proBNP levels were associated significantly with the risk of dementia in the entire study population (HR 1.32, 95%CI 1.17-1.56, p = 0.001) per 1SD difference, adjusted for multiple cardiovascular risk factors. Integrated discrimination improvement (IDI) and continuous net-reclassification improvement (continuous NRI) were improved in the study population over 40 years of age: continuous NRI was 17.5% (95%CI 4.4-30.6%, p = 0.009) and IDI was 0.005 (95%CI 0.001-0.010, p = 0.021). Regarding AD, the HR for 1SD logNT-proBNP change was 1.23 (95%CI 1.01-1.49, p = 0.040) in the entire study population, but no IDI or continuous NRI improvement was seen.CONCLUSION: NT-proBNP is also an independent risk marker for dementia, and patient discrimination regarding dementia risk could be improved by using it.
KW - Adult
KW - Age Factors
KW - Aged
KW - Cohort Studies
KW - Dementia/metabolism
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Natriuretic Peptide, Brain/metabolism
KW - Peptide Fragments/metabolism
KW - Proportional Hazards Models
KW - Risk Factors
KW - Sex Factors
U2 - 10.3233/JAD-141809
DO - 10.3233/JAD-141809
M3 - SCORING: Journal article
C2 - 25408211
VL - 44
SP - 1007
EP - 1013
JO - J ALZHEIMERS DIS
JF - J ALZHEIMERS DIS
SN - 1387-2877
IS - 3
ER -
