N-terminal tagging of two-pore channels interferes with NAADP action
Related Research units
Abstract
NAADP (nicotinic acid-adenine dinucleotide phosphate) is the most potent Ca2+-releasing second messenger known to date. Since its discovery in 1995 identifying the NAADP receptor protein/Ca2+ channel has been a major persuit of the Ca2+ signalling community. In their paper 'The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP' published in this issue of the Biochemical Journal Patel and colleagues describe that the N-terminus of one of the NAADP receptor protein/Ca2+ channel candidates, TPC1 (two-pore channel 1), is crucial for protein targeting and for sensitivity to NAADP.
Bibliographical data
Original language | English |
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ISSN | 0264-6021 |
DOIs | |
Publication status | Published - 01.07.2013 |
Comment Deanary
Commentary, nicht OA
PubMed | 23763317 |
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