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Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification

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Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification. / Sorajja, Paul; Gössl, Mario; Babaliaros, Vasilis; Rizik, David; Conradi, Lenard; Bae, Richard; Burke, Robert F; Schäfer, Ulrich; Lisko, John C; Riley, Robert D; Guyton, Robert; Dumonteil, Nicolas; Berthoumieu, Pierre; Tchetche, Didier; Blanke, Philipp; Cavalcante, João L; Sun, Benjamin.

In: J AM COLL CARDIOL, Vol. 74, No. 11, 17.09.2019, p. 1431-1440.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sorajja, P, Gössl, M, Babaliaros, V, Rizik, D, Conradi, L, Bae, R, Burke, RF, Schäfer, U, Lisko, JC, Riley, RD, Guyton, R, Dumonteil, N, Berthoumieu, P, Tchetche, D, Blanke, P, Cavalcante, JL & Sun, B 2019, 'Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification', J AM COLL CARDIOL, vol. 74, no. 11, pp. 1431-1440. https://doi.org/10.1016/j.jacc.2019.07.069

APA

Sorajja, P., Gössl, M., Babaliaros, V., Rizik, D., Conradi, L., Bae, R., Burke, R. F., Schäfer, U., Lisko, J. C., Riley, R. D., Guyton, R., Dumonteil, N., Berthoumieu, P., Tchetche, D., Blanke, P., Cavalcante, J. L., & Sun, B. (2019). Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification. J AM COLL CARDIOL, 74(11), 1431-1440. https://doi.org/10.1016/j.jacc.2019.07.069

Vancouver

Sorajja P, Gössl M, Babaliaros V, Rizik D, Conradi L, Bae R et al. Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification. J AM COLL CARDIOL. 2019 Sep 17;74(11):1431-1440. https://doi.org/10.1016/j.jacc.2019.07.069

Bibtex

@article{3855e4d685cd44a99563a7a4aaa59edd,
title = "Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification",
abstract = "BACKGROUND: Treatment of mitral regurgitation (MR) in the setting of severe mitral annular calcification (MAC) is challenging due to the high risk for fatal atrioventricular groove disruption and significant paravalvular leak.OBJECTIVES: The objective of this study was to evaluate the potential for transcatheter mitral valve replacement in patients with severe MAC using an anatomically designed mitral prosthesis.METHODS: Nine patients (77 ± 6 years of age; 5 men) were treated with the valve, using transapical delivery performed under general anesthesia and with guidance from transesophageal echocardiography and fluoroscopy.RESULTS: Device implantation was successful with relief of MR in all 9 patients. There were no procedural deaths. In 1 patient, left ventricular outflow tract obstruction occurred due to malrotation of the prosthesis, and successful alcohol septal ablation was performed. During a median follow-up of 12 months (range 1 to 28 months), there was 1 cardiac death, 1 noncardiac death, no other mortality, and no prosthetic dysfunction, and MR remained absent in all treated patients. Rehospitalization for heart failure occurred in 2 patients who did not die subsequently. Clinical improvement with mild or no symptoms occurred in all patients alive at the end of follow-up.CONCLUSIONS: Transcatheter mitral valve replacement in severe mitral annular calcification with a dedicated prosthesis is feasible and can result in MR relief with symptom improvement. Further evaluation of this approach for these high-risk patients is warranted.",
keywords = "Aged, Aged, 80 and over, Calcinosis/surgery, Cardiac Catheterization, Female, Heart Valve Diseases/surgery, Heart Valve Prosthesis Implantation/methods, Humans, Male, Mitral Valve/surgery, Severity of Illness Index",
author = "Paul Sorajja and Mario G{\"o}ssl and Vasilis Babaliaros and David Rizik and Lenard Conradi and Richard Bae and Burke, {Robert F} and Ulrich Sch{\"a}fer and Lisko, {John C} and Riley, {Robert D} and Robert Guyton and Nicolas Dumonteil and Pierre Berthoumieu and Didier Tchetche and Philipp Blanke and Cavalcante, {Jo{\~a}o L} and Benjamin Sun",
note = "Copyright {\textcopyright} 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = sep,
day = "17",
doi = "10.1016/j.jacc.2019.07.069",
language = "English",
volume = "74",
pages = "1431--1440",
journal = "J AM COLL CARDIOL",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "11",

}

RIS

TY - JOUR

T1 - Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification

AU - Sorajja, Paul

AU - Gössl, Mario

AU - Babaliaros, Vasilis

AU - Rizik, David

AU - Conradi, Lenard

AU - Bae, Richard

AU - Burke, Robert F

AU - Schäfer, Ulrich

AU - Lisko, John C

AU - Riley, Robert D

AU - Guyton, Robert

AU - Dumonteil, Nicolas

AU - Berthoumieu, Pierre

AU - Tchetche, Didier

AU - Blanke, Philipp

AU - Cavalcante, João L

AU - Sun, Benjamin

N1 - Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2019/9/17

Y1 - 2019/9/17

N2 - BACKGROUND: Treatment of mitral regurgitation (MR) in the setting of severe mitral annular calcification (MAC) is challenging due to the high risk for fatal atrioventricular groove disruption and significant paravalvular leak.OBJECTIVES: The objective of this study was to evaluate the potential for transcatheter mitral valve replacement in patients with severe MAC using an anatomically designed mitral prosthesis.METHODS: Nine patients (77 ± 6 years of age; 5 men) were treated with the valve, using transapical delivery performed under general anesthesia and with guidance from transesophageal echocardiography and fluoroscopy.RESULTS: Device implantation was successful with relief of MR in all 9 patients. There were no procedural deaths. In 1 patient, left ventricular outflow tract obstruction occurred due to malrotation of the prosthesis, and successful alcohol septal ablation was performed. During a median follow-up of 12 months (range 1 to 28 months), there was 1 cardiac death, 1 noncardiac death, no other mortality, and no prosthetic dysfunction, and MR remained absent in all treated patients. Rehospitalization for heart failure occurred in 2 patients who did not die subsequently. Clinical improvement with mild or no symptoms occurred in all patients alive at the end of follow-up.CONCLUSIONS: Transcatheter mitral valve replacement in severe mitral annular calcification with a dedicated prosthesis is feasible and can result in MR relief with symptom improvement. Further evaluation of this approach for these high-risk patients is warranted.

AB - BACKGROUND: Treatment of mitral regurgitation (MR) in the setting of severe mitral annular calcification (MAC) is challenging due to the high risk for fatal atrioventricular groove disruption and significant paravalvular leak.OBJECTIVES: The objective of this study was to evaluate the potential for transcatheter mitral valve replacement in patients with severe MAC using an anatomically designed mitral prosthesis.METHODS: Nine patients (77 ± 6 years of age; 5 men) were treated with the valve, using transapical delivery performed under general anesthesia and with guidance from transesophageal echocardiography and fluoroscopy.RESULTS: Device implantation was successful with relief of MR in all 9 patients. There were no procedural deaths. In 1 patient, left ventricular outflow tract obstruction occurred due to malrotation of the prosthesis, and successful alcohol septal ablation was performed. During a median follow-up of 12 months (range 1 to 28 months), there was 1 cardiac death, 1 noncardiac death, no other mortality, and no prosthetic dysfunction, and MR remained absent in all treated patients. Rehospitalization for heart failure occurred in 2 patients who did not die subsequently. Clinical improvement with mild or no symptoms occurred in all patients alive at the end of follow-up.CONCLUSIONS: Transcatheter mitral valve replacement in severe mitral annular calcification with a dedicated prosthesis is feasible and can result in MR relief with symptom improvement. Further evaluation of this approach for these high-risk patients is warranted.

KW - Aged

KW - Aged, 80 and over

KW - Calcinosis/surgery

KW - Cardiac Catheterization

KW - Female

KW - Heart Valve Diseases/surgery

KW - Heart Valve Prosthesis Implantation/methods

KW - Humans

KW - Male

KW - Mitral Valve/surgery

KW - Severity of Illness Index

U2 - 10.1016/j.jacc.2019.07.069

DO - 10.1016/j.jacc.2019.07.069

M3 - SCORING: Journal article

C2 - 31514943

VL - 74

SP - 1431

EP - 1440

JO - J AM COLL CARDIOL

JF - J AM COLL CARDIOL

SN - 0735-1097

IS - 11

ER -