Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes.
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Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes. / Li, Lingjun; Siebrands, Cornelia; Yang, Zhenjun; Zhang, Liangren; Guse, Andreas H.; Zhang, Lihe.
In: ORG BIOMOL CHEM, Vol. 8, No. 8, 8, 2010, p. 1843-1848.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes.
AU - Li, Lingjun
AU - Siebrands, Cornelia
AU - Yang, Zhenjun
AU - Zhang, Liangren
AU - Guse, Andreas H.
AU - Zhang, Lihe
PY - 2010
Y1 - 2010
N2 - A purine nucleobase-simplified cyclic ADP ribose (cADPR) analogue was synthesized, in which a 1,2,3-triazole-4-amide was constructed, instead of a purine moiety, and the northern ribose was replaced by an ether strand. Compound exhibits calcium release activity in intact T-lymphocytes and indicates that it is a membrane-permeable cADPR mimic. Thus, the cADPR analogue containing 1,2,3-triazole-4-amide provides a novel template for further designing cADPR analogues and elucidating their structure-activity relationships.
AB - A purine nucleobase-simplified cyclic ADP ribose (cADPR) analogue was synthesized, in which a 1,2,3-triazole-4-amide was constructed, instead of a purine moiety, and the northern ribose was replaced by an ether strand. Compound exhibits calcium release activity in intact T-lymphocytes and indicates that it is a membrane-permeable cADPR mimic. Thus, the cADPR analogue containing 1,2,3-triazole-4-amide provides a novel template for further designing cADPR analogues and elucidating their structure-activity relationships.
M3 - SCORING: Zeitschriftenaufsatz
VL - 8
SP - 1843
EP - 1848
IS - 8
M1 - 8
ER -
