Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern
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Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern. / Kanawade, Rajesh; Klämpfl, Florian; Riemann, Max; Knipfer, Christian; Tangermann-Gerk, Katja; Schmidt, Michael; Stelzle, Florian.
In: J BIOPHOTONICS, Vol. 7, No. 10, 10.2014, p. 841-9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern
AU - Kanawade, Rajesh
AU - Klämpfl, Florian
AU - Riemann, Max
AU - Knipfer, Christian
AU - Tangermann-Gerk, Katja
AU - Schmidt, Michael
AU - Stelzle, Florian
N1 - Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2014/10
Y1 - 2014/10
N2 - The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The preliminary study has shown that this method can monitor the spatial distribution of capillary/vessel spatial patterns through local blood volume fractions of reduced hemoglobin and oxyhemoglobin. This method can be used as a real-time and non-invasive tool for the monitoring of shock development and feedback on the therapeutic intervention.
AB - The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The preliminary study has shown that this method can monitor the spatial distribution of capillary/vessel spatial patterns through local blood volume fractions of reduced hemoglobin and oxyhemoglobin. This method can be used as a real-time and non-invasive tool for the monitoring of shock development and feedback on the therapeutic intervention.
KW - Blood Volume
KW - Blood Volume Determination
KW - Capillaries
KW - Hemoglobins
KW - Models, Anatomic
KW - Models, Biological
KW - Monitoring, Physiologic
KW - Optical Imaging
KW - Oxyhemoglobins
KW - Regional Blood Flow
KW - Shock
KW - Skin Physiological Phenomena
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/jbio.201300065
DO - 10.1002/jbio.201300065
M3 - SCORING: Journal article
C2 - 23843326
VL - 7
SP - 841
EP - 849
JO - J BIOPHOTONICS
JF - J BIOPHOTONICS
SN - 1864-063X
IS - 10
ER -