Novel gene hKCNE4 slows the activation of the KCNQ1 channel.
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Novel gene hKCNE4 slows the activation of the KCNQ1 channel. / Teng, Siyong; Ma, Lijuan; Zhen, Yisong; Lin, ChunXia; Bähring, Robert; Vardanyan, Vitya; Pongs, Olaf; Hui, Rutai.
In: BIOCHEM BIOPH RES CO, Vol. 303, No. 3, 3, 2003, p. 808-813.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Novel gene hKCNE4 slows the activation of the KCNQ1 channel.
AU - Teng, Siyong
AU - Ma, Lijuan
AU - Zhen, Yisong
AU - Lin, ChunXia
AU - Bähring, Robert
AU - Vardanyan, Vitya
AU - Pongs, Olaf
AU - Hui, Rutai
PY - 2003
Y1 - 2003
N2 - The KCNE genes encode small, single transmembrane domain peptides that associate with pore-forming potassium channel subunits to form mixed complexes with unique characteristics. We have identified a novel member of the human KCNE gene family, hKCNE4. The hKCNE4 gene encodes 170 amino acid protein and is localized to chromosome 2q35-36. The protein sequence shows 90% homology to mouse KCNE4 and 38% identity to human KCNE1. Northern blot analysis revealed that hKCNE4 is expressed strongly in heart, skeletal muscle, and kidney, less in placenta, lung, and liver, and weakly in brain and blood cells. Electrophysiological study showed that hKCNE4 modulates the activation of the KCNQ1 channel.
AB - The KCNE genes encode small, single transmembrane domain peptides that associate with pore-forming potassium channel subunits to form mixed complexes with unique characteristics. We have identified a novel member of the human KCNE gene family, hKCNE4. The hKCNE4 gene encodes 170 amino acid protein and is localized to chromosome 2q35-36. The protein sequence shows 90% homology to mouse KCNE4 and 38% identity to human KCNE1. Northern blot analysis revealed that hKCNE4 is expressed strongly in heart, skeletal muscle, and kidney, less in placenta, lung, and liver, and weakly in brain and blood cells. Electrophysiological study showed that hKCNE4 modulates the activation of the KCNQ1 channel.
M3 - SCORING: Zeitschriftenaufsatz
VL - 303
SP - 808
EP - 813
JO - BIOCHEM BIOPH RES CO
JF - BIOCHEM BIOPH RES CO
SN - 0006-291X
IS - 3
M1 - 3
ER -