Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect

TY - JOUR

T1 - Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect

AU - Radecke, Jan-Ole

AU - Sprenger, Andreas

AU - Stöckler, Hannah

AU - Espeter, Lisa

AU - Reichhardt, Mandy-Josephine

AU - Thomann, Lara S

AU - Erdbrügger, Tim

AU - Buschermöhle, Yvonne

AU - Borgwardt, Stefan

AU - Schneider, Till R

AU - Gross, Joachim

AU - Wolters, Carsten H

AU - Lencer, Rebekka

N1 - © 2023. The Author(s).

PY - 2023/12/4

Y1 - 2023/12/4

N2 - The neural networks subserving smooth pursuit eye movements (SPEM) provide an ideal model for investigating the interaction of sensory processing and motor control during ongoing movements. To better understand core plasticity aspects of sensorimotor processing for SPEM, normative sham, anodal or cathodal transcranial direct current stimulation (tDCS) was applied over visual area V5 and frontal eye fields (FEF) in sixty healthy participants. The identical within-subject paradigm was used to assess SPEM modulations by practice. While no specific tDCS effects were revealed, within- and between-session practice effects indicate plasticity of top-down extraretinal mechanisms that mainly affect SPEM in the absence of visual input and during SPEM initiation. To explore the potential of tDCS effects, individual electric field simulations were computed based on calibrated finite element head models and individual functional localization of V5 and FEF location (using functional MRI) and orientation (using combined EEG/MEG) was conducted. Simulations revealed only limited electric field target intensities induced by the applied normative tDCS montages but indicate the potential efficacy of personalized tDCS for the modulation of SPEM. In sum, results indicate the potential susceptibility of extraretinal SPEM control to targeted external neuromodulation (e.g., personalized tDCS) and intrinsic learning protocols.

AB - The neural networks subserving smooth pursuit eye movements (SPEM) provide an ideal model for investigating the interaction of sensory processing and motor control during ongoing movements. To better understand core plasticity aspects of sensorimotor processing for SPEM, normative sham, anodal or cathodal transcranial direct current stimulation (tDCS) was applied over visual area V5 and frontal eye fields (FEF) in sixty healthy participants. The identical within-subject paradigm was used to assess SPEM modulations by practice. While no specific tDCS effects were revealed, within- and between-session practice effects indicate plasticity of top-down extraretinal mechanisms that mainly affect SPEM in the absence of visual input and during SPEM initiation. To explore the potential of tDCS effects, individual electric field simulations were computed based on calibrated finite element head models and individual functional localization of V5 and FEF location (using functional MRI) and orientation (using combined EEG/MEG) was conducted. Simulations revealed only limited electric field target intensities induced by the applied normative tDCS montages but indicate the potential efficacy of personalized tDCS for the modulation of SPEM. In sum, results indicate the potential susceptibility of extraretinal SPEM control to targeted external neuromodulation (e.g., personalized tDCS) and intrinsic learning protocols.

KW - Humans

KW - Transcranial Direct Current Stimulation/methods

KW - Pursuit, Smooth

KW - Frontal Lobe

KW - Magnetic Resonance Imaging/methods

U2 - 10.1038/s41598-023-48313-z

DO - 10.1038/s41598-023-48313-z

M3 - SCORING: Journal article

C2 - 38049419

VL - 13

SP - 21380

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -