Nontransferrin-bound iron in serum of patients receiving bone marrow transplants.
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Nontransferrin-bound iron in serum of patients receiving bone marrow transplants. / Dürken, M; Nielsen, Peter; Knobel, S; Finckh, B; Herrnring, C; Dresow, B; Kohlschütter, B; Stockschläder, M; Krüger, W H; Kohlschütter, A; Zander, A R.
In: FREE RADICAL BIO MED, Vol. 22, No. 7, 7, 1997, p. 1159-1163.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Nontransferrin-bound iron in serum of patients receiving bone marrow transplants.
AU - Dürken, M
AU - Nielsen, Peter
AU - Knobel, S
AU - Finckh, B
AU - Herrnring, C
AU - Dresow, B
AU - Kohlschütter, B
AU - Stockschläder, M
AU - Krüger, W H
AU - Kohlschütter, A
AU - Zander, A R
PY - 1997
Y1 - 1997
N2 - Nontransferrin-bound iron (NTBI) and other parameters of iron status were measured in 40 patients undergoing bone marrow transplantation (BMT) prior to conditioning therapy (between day -10 and -7), at the time of BMT (day 0), and 2 weeks later (day + 14). Serum iron and transferrin saturation values were normal before conditioning therapy. At day 0 serum iron values were high and median transferrin saturation was 98% (changes in the values of both serum iron and transferrin saturation, p <.0001). Transferrin saturation values were still elevated 2 weeks posttransplant (day +14 vs. baseline values, p = .0001). Starting at low NTBI levels pretransplant (median 0.4 micromol/l, range 0-4.2 micromol/l, controls: <or = 0.4 micromol/l), all patients revealed high levels on day 0 (median 4.0 micromol/l, range 1.9-6.9 micromol/l, p <.0001) and 2 weeks posttransplant (median 2.7 micromol/l, range 0-6.2 micromol/l, p <.0001). These observations indicate that the plasma iron pool in patients undergoing BMT increases to a level at which the normal ability to sequestrate iron becomes exhausted and considerable amounts of NTBI appear in serum. This "free" form of iron can mediate the production of reactive oxygen species and may cause organ toxicity in the early posttransplantation period.
AB - Nontransferrin-bound iron (NTBI) and other parameters of iron status were measured in 40 patients undergoing bone marrow transplantation (BMT) prior to conditioning therapy (between day -10 and -7), at the time of BMT (day 0), and 2 weeks later (day + 14). Serum iron and transferrin saturation values were normal before conditioning therapy. At day 0 serum iron values were high and median transferrin saturation was 98% (changes in the values of both serum iron and transferrin saturation, p <.0001). Transferrin saturation values were still elevated 2 weeks posttransplant (day +14 vs. baseline values, p = .0001). Starting at low NTBI levels pretransplant (median 0.4 micromol/l, range 0-4.2 micromol/l, controls: <or = 0.4 micromol/l), all patients revealed high levels on day 0 (median 4.0 micromol/l, range 1.9-6.9 micromol/l, p <.0001) and 2 weeks posttransplant (median 2.7 micromol/l, range 0-6.2 micromol/l, p <.0001). These observations indicate that the plasma iron pool in patients undergoing BMT increases to a level at which the normal ability to sequestrate iron becomes exhausted and considerable amounts of NTBI appear in serum. This "free" form of iron can mediate the production of reactive oxygen species and may cause organ toxicity in the early posttransplantation period.
M3 - SCORING: Zeitschriftenaufsatz
VL - 22
SP - 1159
EP - 1163
JO - FREE RADICAL BIO MED
JF - FREE RADICAL BIO MED
SN - 0891-5849
IS - 7
M1 - 7
ER -
