Research ExplorerPublicationsNon-organ-specific autoantibodies with unspecific patterns a...

Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D

Standard

Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D. / Hermanussen, Lennart; Lampalzer, Sibylle; Bockmann, Jan-Hendrik; Ziegler, Annerose E; Piecha, Felix; Dandri, Maura; Pischke, Sven; Haag, Friedrich; Lohse, Ansgar W; Lütgehetmann, Marc; Weiler-Normann, Christina; Zur Wiesch, Julian Schulze.

In: FRONT MED-LAUSANNE, Vol. 10, 2023, p. 1169096.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hermanussen, L, Lampalzer, S, Bockmann, J-H, Ziegler, AE, Piecha, F, Dandri, M, Pischke, S, Haag, F, Lohse, AW, Lütgehetmann, M, Weiler-Normann, C & Zur Wiesch, JS 2023, 'Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D', FRONT MED-LAUSANNE, vol. 10, pp. 1169096. https://doi.org/10.3389/fmed.2023.1169096

APA

Hermanussen, L., Lampalzer, S., Bockmann, J-H., Ziegler, A. E., Piecha, F., Dandri, M., Pischke, S., Haag, F., Lohse, A. W., Lütgehetmann, M., Weiler-Normann, C., & Zur Wiesch, J. S. (2023). Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D. FRONT MED-LAUSANNE, 10, 1169096. https://doi.org/10.3389/fmed.2023.1169096

Vancouver

Hermanussen L, Lampalzer S, Bockmann J-H, Ziegler AE, Piecha F, Dandri M et al. Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D. FRONT MED-LAUSANNE. 2023;10:1169096. https://doi.org/10.3389/fmed.2023.1169096

Bibtex

@article{785515e0843c4708a2ddb32e325b8055,
title = "Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D",
abstract = "Infections with hepatotropic viruses are associated with various immune phenomena. Hepatitis D virus (HDV) causes the most severe form of viral hepatitis. However, few recent data are available on non-disease-specific and non-organ-specific antibody (NOSA) titers and immunoglobulin G (IgG) levels in chronic hepatitis D (CHD) patients. Here, we examined the NOSA titers and IgG levels of 40 patients with CHD and different disease courses and compared them to 70 patients with chronic hepatitis B (CHB) infection. 43% of CHD patients had previously undergone treatment with pegylated interferon-α (IFN-α). The antibody display of 46 untreated patients diagnosed with autoimmune hepatitis (AIH) was used as a reference. The frequency of elevated NOSA titers (CHD 69% vs. CHB 43%, p < 0.01), and the median IgG levels (CHD 16.9 g/L vs. CHB 12.7 g/L, p < 0.01) were significantly higher in CHD patients than in patients with CHB, and highest in patients with AIH (96%, 19.5 g/L). Also, the antinuclear antibody pattern was homogeneous in many patients with AIH and unspecific in patients with viral hepatitis. Additionally, f-actin autoantibodies were only detectable in patients with AIH (39% of SMA). In CHD patients, IgG levels correlated with higher HDV viral loads, transaminases, and liver stiffness values. IgG levels and NOSA were similar in CHD patients irrespective of a previous IFN-α treatment. In summary, autoantibodies with an unspecific pattern are frequently detected in CHD patients with unclear clinical relevance.",
author = "Lennart Hermanussen and Sibylle Lampalzer and Jan-Hendrik Bockmann and Ziegler, {Annerose E} and Felix Piecha and Maura Dandri and Sven Pischke and Friedrich Haag and Lohse, {Ansgar W} and Marc L{\"u}tgehetmann and Christina Weiler-Normann and {Zur Wiesch}, {Julian Schulze}",
note = "Copyright {\textcopyright} 2023 Hermanussen, Lampalzer, Bockmann, Ziegler, Piecha, Dandri, Pischke, Haag, Lohse, L{\"u}tgehetmann, Weiler-Normann and Wiesch.",
year = "2023",
doi = "10.3389/fmed.2023.1169096",
language = "English",
volume = "10",
pages = "1169096",
journal = "FRONT MED-LAUSANNE",
issn = "2296-858X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Non-organ-specific autoantibodies with unspecific patterns are a frequent para-infectious feature of chronic hepatitis D

AU - Hermanussen, Lennart

AU - Lampalzer, Sibylle

AU - Bockmann, Jan-Hendrik

AU - Ziegler, Annerose E

AU - Piecha, Felix

AU - Dandri, Maura

AU - Pischke, Sven

AU - Haag, Friedrich

AU - Lohse, Ansgar W

AU - Lütgehetmann, Marc

AU - Weiler-Normann, Christina

AU - Zur Wiesch, Julian Schulze

N1 - Copyright © 2023 Hermanussen, Lampalzer, Bockmann, Ziegler, Piecha, Dandri, Pischke, Haag, Lohse, Lütgehetmann, Weiler-Normann and Wiesch.

PY - 2023

Y1 - 2023

N2 - Infections with hepatotropic viruses are associated with various immune phenomena. Hepatitis D virus (HDV) causes the most severe form of viral hepatitis. However, few recent data are available on non-disease-specific and non-organ-specific antibody (NOSA) titers and immunoglobulin G (IgG) levels in chronic hepatitis D (CHD) patients. Here, we examined the NOSA titers and IgG levels of 40 patients with CHD and different disease courses and compared them to 70 patients with chronic hepatitis B (CHB) infection. 43% of CHD patients had previously undergone treatment with pegylated interferon-α (IFN-α). The antibody display of 46 untreated patients diagnosed with autoimmune hepatitis (AIH) was used as a reference. The frequency of elevated NOSA titers (CHD 69% vs. CHB 43%, p < 0.01), and the median IgG levels (CHD 16.9 g/L vs. CHB 12.7 g/L, p < 0.01) were significantly higher in CHD patients than in patients with CHB, and highest in patients with AIH (96%, 19.5 g/L). Also, the antinuclear antibody pattern was homogeneous in many patients with AIH and unspecific in patients with viral hepatitis. Additionally, f-actin autoantibodies were only detectable in patients with AIH (39% of SMA). In CHD patients, IgG levels correlated with higher HDV viral loads, transaminases, and liver stiffness values. IgG levels and NOSA were similar in CHD patients irrespective of a previous IFN-α treatment. In summary, autoantibodies with an unspecific pattern are frequently detected in CHD patients with unclear clinical relevance.

AB - Infections with hepatotropic viruses are associated with various immune phenomena. Hepatitis D virus (HDV) causes the most severe form of viral hepatitis. However, few recent data are available on non-disease-specific and non-organ-specific antibody (NOSA) titers and immunoglobulin G (IgG) levels in chronic hepatitis D (CHD) patients. Here, we examined the NOSA titers and IgG levels of 40 patients with CHD and different disease courses and compared them to 70 patients with chronic hepatitis B (CHB) infection. 43% of CHD patients had previously undergone treatment with pegylated interferon-α (IFN-α). The antibody display of 46 untreated patients diagnosed with autoimmune hepatitis (AIH) was used as a reference. The frequency of elevated NOSA titers (CHD 69% vs. CHB 43%, p < 0.01), and the median IgG levels (CHD 16.9 g/L vs. CHB 12.7 g/L, p < 0.01) were significantly higher in CHD patients than in patients with CHB, and highest in patients with AIH (96%, 19.5 g/L). Also, the antinuclear antibody pattern was homogeneous in many patients with AIH and unspecific in patients with viral hepatitis. Additionally, f-actin autoantibodies were only detectable in patients with AIH (39% of SMA). In CHD patients, IgG levels correlated with higher HDV viral loads, transaminases, and liver stiffness values. IgG levels and NOSA were similar in CHD patients irrespective of a previous IFN-α treatment. In summary, autoantibodies with an unspecific pattern are frequently detected in CHD patients with unclear clinical relevance.

U2 - 10.3389/fmed.2023.1169096

DO - 10.3389/fmed.2023.1169096

M3 - SCORING: Journal article

C2 - 37387781

VL - 10

SP - 1169096

JO - FRONT MED-LAUSANNE

JF - FRONT MED-LAUSANNE

SN - 2296-858X

ER -