Non-invasive qualitative and semiquantitative presurgical investigation of the feeding vasculature to intracranial meningiomas using superselective arterial spin labeling
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Non-invasive qualitative and semiquantitative presurgical investigation of the feeding vasculature to intracranial meningiomas using superselective arterial spin labeling. / Jensen-Kondering, Ulf; Helle, Michael; Lindner, Thomas; Jansen, Olav; Nabavi, Arya.
In: PLOS ONE, Vol. 14, No. 4, 2019, p. e0215145.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Non-invasive qualitative and semiquantitative presurgical investigation of the feeding vasculature to intracranial meningiomas using superselective arterial spin labeling
AU - Jensen-Kondering, Ulf
AU - Helle, Michael
AU - Lindner, Thomas
AU - Jansen, Olav
AU - Nabavi, Arya
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Intracranial meningiomas may be amenable to presurgical embolization to reduce bleeding complications. Detailed information usually obtained by digital subtraction angiography (DSA) on the contribution of blood supply from internal and external carotid artery branches is required to prevent non-target embolization and is helpful for pre-surgical planning.PURPOSE: To investigate the contribution of the feeding vasculature to intracranial meningiomas with superselective arterial spin labelling (sASL) as an alternative to DSA.MATERIAL AND METHODS: Consecutive patients presenting for meningioma resection were prospectively included. sASL perfusion images acquired on a clinical 3T MRI scanner were independently rated by two readers. Contribution of the external carotid artery (ECA), internal carotid artery (ICA) and vertebral/basilar artery (VA/BA) was rated as none, <50% or >50%. Correlation of sASL was performed in two patients undergoing DSA.RESULTS: 32 patients (61 ± 13 years) harboring 42 meningiomas could be included. sASL was technically successful in all patients. 19 meningiomas had ICA dominant supply, 19 had ECA dominant supply. One meningioma had mixed supply and in three meningiomas a perfusion signal could not be detected. While exclusive unilateral ECA supply was common (n = 14) and exclusive unilateral ICA was rare (n = 4), mixed supply from multiple vessels (n = 20) was a frequent finding. Interrater agreement was substantial (κ = 0.73). Agreement with DSA was perfect within our predefined categories.CONCLUSION: sASL is able to identify the presence and extent of the feeding vasculature in intracranial meningiomas.
AB - BACKGROUND: Intracranial meningiomas may be amenable to presurgical embolization to reduce bleeding complications. Detailed information usually obtained by digital subtraction angiography (DSA) on the contribution of blood supply from internal and external carotid artery branches is required to prevent non-target embolization and is helpful for pre-surgical planning.PURPOSE: To investigate the contribution of the feeding vasculature to intracranial meningiomas with superselective arterial spin labelling (sASL) as an alternative to DSA.MATERIAL AND METHODS: Consecutive patients presenting for meningioma resection were prospectively included. sASL perfusion images acquired on a clinical 3T MRI scanner were independently rated by two readers. Contribution of the external carotid artery (ECA), internal carotid artery (ICA) and vertebral/basilar artery (VA/BA) was rated as none, <50% or >50%. Correlation of sASL was performed in two patients undergoing DSA.RESULTS: 32 patients (61 ± 13 years) harboring 42 meningiomas could be included. sASL was technically successful in all patients. 19 meningiomas had ICA dominant supply, 19 had ECA dominant supply. One meningioma had mixed supply and in three meningiomas a perfusion signal could not be detected. While exclusive unilateral ECA supply was common (n = 14) and exclusive unilateral ICA was rare (n = 4), mixed supply from multiple vessels (n = 20) was a frequent finding. Interrater agreement was substantial (κ = 0.73). Agreement with DSA was perfect within our predefined categories.CONCLUSION: sASL is able to identify the presence and extent of the feeding vasculature in intracranial meningiomas.
KW - Angiography, Digital Subtraction/methods
KW - Carotid Artery, External/diagnostic imaging
KW - Carotid Artery, Internal/diagnostic imaging
KW - Embolization, Therapeutic
KW - Female
KW - Humans
KW - Male
KW - Meningeal Neoplasms/blood supply
KW - Meningioma/blood supply
KW - Middle Aged
KW - Preoperative Care
KW - Spin Labels
U2 - 10.1371/journal.pone.0215145
DO - 10.1371/journal.pone.0215145
M3 - SCORING: Journal article
C2 - 30964922
VL - 14
SP - e0215145
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 4
ER -
