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Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population

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Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population. / Schnabel, Renate B; Magnussen, Christina; Schulz, Andreas; Ojeda, Francisco M; Schmitt, Volker H; Arnold, Natalie; Sinning, Christoph R; Beutel, Manfred E; Schmidtmann, Irene; Pfeiffer, Norbert; Leuschner, Anja; Lackner, Karl J; Gori, Tommaso; Benjamin, Emelia J; Binder, Harald; Wild, Philipp S; Blankenberg, Stefan; Münzel, Thomas; Gutenberg Health Study investigators.

In: CARDIOVASC RES, Vol. 118, No. 3, 21.02.2022, p. 904-912.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schnabel, RB, Magnussen, C, Schulz, A, Ojeda, FM, Schmitt, VH, Arnold, N, Sinning, CR, Beutel, ME, Schmidtmann, I, Pfeiffer, N, Leuschner, A, Lackner, KJ, Gori, T, Benjamin, EJ, Binder, H, Wild, PS, Blankenberg, S, Münzel, T & Gutenberg Health Study investigators 2022, 'Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population', CARDIOVASC RES, vol. 118, no. 3, pp. 904-912. https://doi.org/10.1093/cvr/cvab087

APA

Schnabel, R. B., Magnussen, C., Schulz, A., Ojeda, F. M., Schmitt, V. H., Arnold, N., Sinning, C. R., Beutel, M. E., Schmidtmann, I., Pfeiffer, N., Leuschner, A., Lackner, K. J., Gori, T., Benjamin, E. J., Binder, H., Wild, P. S., Blankenberg, S., Münzel, T., & Gutenberg Health Study investigators (2022). Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population. CARDIOVASC RES, 118(3), 904-912. https://doi.org/10.1093/cvr/cvab087

Vancouver

Schnabel RB, Magnussen C, Schulz A, Ojeda FM, Schmitt VH, Arnold N et al. Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population. CARDIOVASC RES. 2022 Feb 21;118(3):904-912. https://doi.org/10.1093/cvr/cvab087

Bibtex

@article{3745741a5e0f437a89d6e1290b67973d,
title = "Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population",
abstract = "AIMS : Evidence suggests that peripheral vascular function is related to cardiovascular disease (CVD) and mortality. We evaluated the associations of non-invasive measures of flow-mediated dilatation and peripheral arterial tonometry with incident CVD and mortality.METHODS AND RESULTS : In a post-hoc analysis of the community-based Gutenberg Health Study, median age 55 years (25th/75th percentile 46/65) and 49.5% women, we measured brachial artery flow-mediated dilatation (N=12 599) and fingertip peripheral arterial tonometry (N=11 125). After a follow-up of up to 11.7 years, we observed 595 incident CVD events, 106 cardiac deaths, and 860 deaths in total. Survival curves showed decreased event-free survival with higher mean brachial artery diameter and baseline pulse amplitude and better survival with higher mean flow-mediated dilatation and peripheral arterial tonometry ratio (all Plog rank <0.05). In multivariable-adjusted Cox regression analyses only baseline pulse amplitude was inversely related to mortality [hazard ratio (HR) per standard deviation increase, 0.86, 95% confidence interval (95% CI), 0.79-0.94; P=0.0009]. After exclusion of individuals with prevalent CVD the association was no longer statistically significant in multivariable-adjusted models (HR 0.91, 95% CI 0.81-1.02; P=0.11). None of the vascular variables substantially increased the C-index of a model comprising clinical risk factors.CONCLUSIONS : In our cohort, non-invasive measures of peripheral vascular structure and function did not reveal clinically relevant associations with incident CVD or mortality. Whether determination of pulse amplitude by peripheral arterial tonometry improves clinical decision-making in primary prevention needs to be demonstrated.",
author = "Schnabel, {Renate B} and Christina Magnussen and Andreas Schulz and Ojeda, {Francisco M} and Schmitt, {Volker H} and Natalie Arnold and Sinning, {Christoph R} and Beutel, {Manfred E} and Irene Schmidtmann and Norbert Pfeiffer and Anja Leuschner and Lackner, {Karl J} and Tommaso Gori and Benjamin, {Emelia J} and Harald Binder and Wild, {Philipp S} and Stefan Blankenberg and Thomas M{\"u}nzel and {Gutenberg Health Study investigators}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.",
year = "2022",
month = feb,
day = "21",
doi = "10.1093/cvr/cvab087",
language = "English",
volume = "118",
pages = "904--912",
journal = "CARDIOVASC RES",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population

AU - Schnabel, Renate B

AU - Magnussen, Christina

AU - Schulz, Andreas

AU - Ojeda, Francisco M

AU - Schmitt, Volker H

AU - Arnold, Natalie

AU - Sinning, Christoph R

AU - Beutel, Manfred E

AU - Schmidtmann, Irene

AU - Pfeiffer, Norbert

AU - Leuschner, Anja

AU - Lackner, Karl J

AU - Gori, Tommaso

AU - Benjamin, Emelia J

AU - Binder, Harald

AU - Wild, Philipp S

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Gutenberg Health Study investigators

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

PY - 2022/2/21

Y1 - 2022/2/21

N2 - AIMS : Evidence suggests that peripheral vascular function is related to cardiovascular disease (CVD) and mortality. We evaluated the associations of non-invasive measures of flow-mediated dilatation and peripheral arterial tonometry with incident CVD and mortality.METHODS AND RESULTS : In a post-hoc analysis of the community-based Gutenberg Health Study, median age 55 years (25th/75th percentile 46/65) and 49.5% women, we measured brachial artery flow-mediated dilatation (N=12 599) and fingertip peripheral arterial tonometry (N=11 125). After a follow-up of up to 11.7 years, we observed 595 incident CVD events, 106 cardiac deaths, and 860 deaths in total. Survival curves showed decreased event-free survival with higher mean brachial artery diameter and baseline pulse amplitude and better survival with higher mean flow-mediated dilatation and peripheral arterial tonometry ratio (all Plog rank <0.05). In multivariable-adjusted Cox regression analyses only baseline pulse amplitude was inversely related to mortality [hazard ratio (HR) per standard deviation increase, 0.86, 95% confidence interval (95% CI), 0.79-0.94; P=0.0009]. After exclusion of individuals with prevalent CVD the association was no longer statistically significant in multivariable-adjusted models (HR 0.91, 95% CI 0.81-1.02; P=0.11). None of the vascular variables substantially increased the C-index of a model comprising clinical risk factors.CONCLUSIONS : In our cohort, non-invasive measures of peripheral vascular structure and function did not reveal clinically relevant associations with incident CVD or mortality. Whether determination of pulse amplitude by peripheral arterial tonometry improves clinical decision-making in primary prevention needs to be demonstrated.

AB - AIMS : Evidence suggests that peripheral vascular function is related to cardiovascular disease (CVD) and mortality. We evaluated the associations of non-invasive measures of flow-mediated dilatation and peripheral arterial tonometry with incident CVD and mortality.METHODS AND RESULTS : In a post-hoc analysis of the community-based Gutenberg Health Study, median age 55 years (25th/75th percentile 46/65) and 49.5% women, we measured brachial artery flow-mediated dilatation (N=12 599) and fingertip peripheral arterial tonometry (N=11 125). After a follow-up of up to 11.7 years, we observed 595 incident CVD events, 106 cardiac deaths, and 860 deaths in total. Survival curves showed decreased event-free survival with higher mean brachial artery diameter and baseline pulse amplitude and better survival with higher mean flow-mediated dilatation and peripheral arterial tonometry ratio (all Plog rank <0.05). In multivariable-adjusted Cox regression analyses only baseline pulse amplitude was inversely related to mortality [hazard ratio (HR) per standard deviation increase, 0.86, 95% confidence interval (95% CI), 0.79-0.94; P=0.0009]. After exclusion of individuals with prevalent CVD the association was no longer statistically significant in multivariable-adjusted models (HR 0.91, 95% CI 0.81-1.02; P=0.11). None of the vascular variables substantially increased the C-index of a model comprising clinical risk factors.CONCLUSIONS : In our cohort, non-invasive measures of peripheral vascular structure and function did not reveal clinically relevant associations with incident CVD or mortality. Whether determination of pulse amplitude by peripheral arterial tonometry improves clinical decision-making in primary prevention needs to be demonstrated.

U2 - 10.1093/cvr/cvab087

DO - 10.1093/cvr/cvab087

M3 - SCORING: Journal article

C2 - 33724298

VL - 118

SP - 904

EP - 912

JO - CARDIOVASC RES

JF - CARDIOVASC RES

SN - 0008-6363

IS - 3

ER -