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Noninvasive fluorescence imaging in animal models of stroke

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Noninvasive fluorescence imaging in animal models of stroke. / Stemmer, N; Mehnert, Jan; Steinbrink, J; Wunder, A.

In: CURR TOP MED CHEM, Vol. 19, No. 28, 2012, p. 4786-4793.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stemmer, N, Mehnert, J, Steinbrink, J & Wunder, A 2012, 'Noninvasive fluorescence imaging in animal models of stroke', CURR TOP MED CHEM, vol. 19, no. 28, pp. 4786-4793. https://doi.org/10.2174/092986712803341494

APA

Stemmer, N., Mehnert, J., Steinbrink, J., & Wunder, A. (2012). Noninvasive fluorescence imaging in animal models of stroke. CURR TOP MED CHEM, 19(28), 4786-4793. https://doi.org/10.2174/092986712803341494

Vancouver

Stemmer N, Mehnert J, Steinbrink J, Wunder A. Noninvasive fluorescence imaging in animal models of stroke. CURR TOP MED CHEM. 2012;19(28):4786-4793. https://doi.org/10.2174/092986712803341494

Bibtex

@article{c4d7938cd1024885a9031d1e3d085aa8,
title = "Noninvasive fluorescence imaging in animal models of stroke",
abstract = "Noninvasive fluorescence imaging (NFI) is a powerful tool to study physiology and pathophysiology in animal disease models. NFI has been successfully applied in a number of animal disease models including cancer, arthritis, and stroke. Furthermore, several applications in humans have been described. NFI is widely available in research laboratories because it has a number of advantages: It uses non-ionizing radiation and requires comparably simple, inexpensive instrumentation, and easy to handle. Fluorochromes can be detected with high sensitivity, and image acquisition time is relatively short. Furthermore, a plethora of fluorescent imaging agents is available including unspecific, target-specific, and activatable imaging probes. With these probes, biological processes such as inflammation, cell death or enzyme activity, and many others can be visualized in living animals. This review offers an overview of current approaches in NFI of stroke pathophysiology in animal models of cerebral ischemia. First, the instrumentation and the different types of imaging agents for NFI are described. Second, a short introduction to animal models of stroke is provided. Third, examples for NFI in animal models of stroke are given. Finally, the use of NFI in human stroke is critically discussed.",
author = "N Stemmer and Jan Mehnert and J Steinbrink and A Wunder",
year = "2012",
doi = "10.2174/092986712803341494",
language = "English",
volume = "19",
pages = "4786--4793",
journal = "CURR TOP MED CHEM",
issn = "1568-0266",
publisher = "Bentham Science Publishers B.V.",
number = "28",

}

RIS

TY - JOUR

T1 - Noninvasive fluorescence imaging in animal models of stroke

AU - Stemmer, N

AU - Mehnert, Jan

AU - Steinbrink, J

AU - Wunder, A

PY - 2012

Y1 - 2012

N2 - Noninvasive fluorescence imaging (NFI) is a powerful tool to study physiology and pathophysiology in animal disease models. NFI has been successfully applied in a number of animal disease models including cancer, arthritis, and stroke. Furthermore, several applications in humans have been described. NFI is widely available in research laboratories because it has a number of advantages: It uses non-ionizing radiation and requires comparably simple, inexpensive instrumentation, and easy to handle. Fluorochromes can be detected with high sensitivity, and image acquisition time is relatively short. Furthermore, a plethora of fluorescent imaging agents is available including unspecific, target-specific, and activatable imaging probes. With these probes, biological processes such as inflammation, cell death or enzyme activity, and many others can be visualized in living animals. This review offers an overview of current approaches in NFI of stroke pathophysiology in animal models of cerebral ischemia. First, the instrumentation and the different types of imaging agents for NFI are described. Second, a short introduction to animal models of stroke is provided. Third, examples for NFI in animal models of stroke are given. Finally, the use of NFI in human stroke is critically discussed.

AB - Noninvasive fluorescence imaging (NFI) is a powerful tool to study physiology and pathophysiology in animal disease models. NFI has been successfully applied in a number of animal disease models including cancer, arthritis, and stroke. Furthermore, several applications in humans have been described. NFI is widely available in research laboratories because it has a number of advantages: It uses non-ionizing radiation and requires comparably simple, inexpensive instrumentation, and easy to handle. Fluorochromes can be detected with high sensitivity, and image acquisition time is relatively short. Furthermore, a plethora of fluorescent imaging agents is available including unspecific, target-specific, and activatable imaging probes. With these probes, biological processes such as inflammation, cell death or enzyme activity, and many others can be visualized in living animals. This review offers an overview of current approaches in NFI of stroke pathophysiology in animal models of cerebral ischemia. First, the instrumentation and the different types of imaging agents for NFI are described. Second, a short introduction to animal models of stroke is provided. Third, examples for NFI in animal models of stroke are given. Finally, the use of NFI in human stroke is critically discussed.

U2 - 10.2174/092986712803341494

DO - 10.2174/092986712803341494

M3 - SCORING: Journal article

C2 - 22873664

VL - 19

SP - 4786

EP - 4793

JO - CURR TOP MED CHEM

JF - CURR TOP MED CHEM

SN - 1568-0266

IS - 28

ER -