Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery

Nina Sauer; Jörg Flitsch; Inga Döing; Viola Dannheim; Till Burkhardt; Jens Aberle

doi:10.1016/j.ghir.2014.03.001

Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery

Standard

Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery. / Sauer, Nina; Flitsch, Jörg; Döing, Inga; Dannheim, Viola; Burkhardt, Till; Aberle, Jens.

In: GROWTH HORM IGF RES, Vol. 24, No. 2-3, 2014, p. 71-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sauer, N, Flitsch, J, Döing, I, Dannheim, V, Burkhardt, T & Aberle, J 2014, 'Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery', GROWTH HORM IGF RES, vol. 24, no. 2-3, pp. 71-5. https://doi.org/10.1016/j.ghir.2014.03.001

APA

Sauer, N., Flitsch, J., Döing, I., Dannheim, V., Burkhardt, T., & Aberle, J. (2014). Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery. GROWTH HORM IGF RES, 24(2-3), 71-5. https://doi.org/10.1016/j.ghir.2014.03.001

Vancouver

Sauer N, Flitsch J, Döing I, Dannheim V, Burkhardt T, Aberle J. Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery. GROWTH HORM IGF RES. 2014;24(2-3):71-5. https://doi.org/10.1016/j.ghir.2014.03.001

Bibtex

@article{18a2ceed6ed943c4a61698da690e9905,

title = "Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery",

abstract = "PURPOSE: Data suggests that substitution of GH in GH-deficient patients may improve quality-of-life and reduce insufficiency-associated-symptoms. Unlike in corticotroph, thyreotroph, or gonadotroph-insufficiency, GH-substitution is usually not started within the first 6-12months after surgery. We aimed to investigate the effect of early-GH-substitution on body-composition, metabolic and pituitary-laboratory-tests, and quality-of-life.METHODS: Data was reviewed from 21 adult-patients who were diagnosed with insufficiency of GH-axis using insulin-hypoglycemia-test. We retrospectively assessed body-composition, metabolic and pituitary-laboratory-tests and quality-of-life for a period of 52-weeks after pituitary-surgery in patients with early GH-substitution (= treated-group, 11-patients) and no GH-substitution (= untreated group, 10-patients).RESULTS: Follow-up-IGF-I-levels of the treated-group stayed within the normal range and differed significantly from the untreated-group. Bioelectrical-impedance-analysis showed a significant decrease of impedance, a significant increase of lean-body-mass and a significant difference in health status in the treated group (p<0.05). Average increase in HDL-level was 2.1mg/dl in the untreated compared to an average decrease of 0.2mg/dl in the treated-group. Lp(a)-levels were reduced by 4.1mg/dl in the treated and by 2.7mg/dl in the untreated-group. Both groups showed an initial-mean-life-satisfaction below average (-0.9 and -1.2). Within one year after surgery mean-health-status improved in both groups. The difference in health-status after 1-year compared to the health-status of the previous year was statistically different between both groups with a greater benefit in the treated-group. Finally there was a trend detectably pointing towards an improvement in pituitary-function (LH- and FSH-recovery) if GH was substituted.CONCLUSION: Early GH-substitution leads to a significant improvement in quality-of-life and body-composition after pituitary-surgery. It is possible that pituitary-function recovers more with early-GH-substitution.",

author = "Nina Sauer and J{\"o}rg Flitsch and Inga D{\"o}ing and Viola Dannheim and Till Burkhardt and Jens Aberle",

year = "2014",

doi = "10.1016/j.ghir.2014.03.001",

language = "English",

volume = "24",

pages = "71--5",

journal = "GROWTH HORM IGF RES",

issn = "1096-6374",

publisher = "Churchill Livingstone",

number = "2-3",

}

RIS

TY - JOUR

T1 - Non-functioning pituitary macroadenomas: Benefit from early growth hormone substitution after surgery

AU - Sauer, Nina

AU - Flitsch, Jörg

AU - Döing, Inga

AU - Dannheim, Viola

AU - Burkhardt, Till

AU - Aberle, Jens

PY - 2014

Y1 - 2014

N2 - PURPOSE: Data suggests that substitution of GH in GH-deficient patients may improve quality-of-life and reduce insufficiency-associated-symptoms. Unlike in corticotroph, thyreotroph, or gonadotroph-insufficiency, GH-substitution is usually not started within the first 6-12months after surgery. We aimed to investigate the effect of early-GH-substitution on body-composition, metabolic and pituitary-laboratory-tests, and quality-of-life.METHODS: Data was reviewed from 21 adult-patients who were diagnosed with insufficiency of GH-axis using insulin-hypoglycemia-test. We retrospectively assessed body-composition, metabolic and pituitary-laboratory-tests and quality-of-life for a period of 52-weeks after pituitary-surgery in patients with early GH-substitution (= treated-group, 11-patients) and no GH-substitution (= untreated group, 10-patients).RESULTS: Follow-up-IGF-I-levels of the treated-group stayed within the normal range and differed significantly from the untreated-group. Bioelectrical-impedance-analysis showed a significant decrease of impedance, a significant increase of lean-body-mass and a significant difference in health status in the treated group (p<0.05). Average increase in HDL-level was 2.1mg/dl in the untreated compared to an average decrease of 0.2mg/dl in the treated-group. Lp(a)-levels were reduced by 4.1mg/dl in the treated and by 2.7mg/dl in the untreated-group. Both groups showed an initial-mean-life-satisfaction below average (-0.9 and -1.2). Within one year after surgery mean-health-status improved in both groups. The difference in health-status after 1-year compared to the health-status of the previous year was statistically different between both groups with a greater benefit in the treated-group. Finally there was a trend detectably pointing towards an improvement in pituitary-function (LH- and FSH-recovery) if GH was substituted.CONCLUSION: Early GH-substitution leads to a significant improvement in quality-of-life and body-composition after pituitary-surgery. It is possible that pituitary-function recovers more with early-GH-substitution.

AB - PURPOSE: Data suggests that substitution of GH in GH-deficient patients may improve quality-of-life and reduce insufficiency-associated-symptoms. Unlike in corticotroph, thyreotroph, or gonadotroph-insufficiency, GH-substitution is usually not started within the first 6-12months after surgery. We aimed to investigate the effect of early-GH-substitution on body-composition, metabolic and pituitary-laboratory-tests, and quality-of-life.METHODS: Data was reviewed from 21 adult-patients who were diagnosed with insufficiency of GH-axis using insulin-hypoglycemia-test. We retrospectively assessed body-composition, metabolic and pituitary-laboratory-tests and quality-of-life for a period of 52-weeks after pituitary-surgery in patients with early GH-substitution (= treated-group, 11-patients) and no GH-substitution (= untreated group, 10-patients).RESULTS: Follow-up-IGF-I-levels of the treated-group stayed within the normal range and differed significantly from the untreated-group. Bioelectrical-impedance-analysis showed a significant decrease of impedance, a significant increase of lean-body-mass and a significant difference in health status in the treated group (p<0.05). Average increase in HDL-level was 2.1mg/dl in the untreated compared to an average decrease of 0.2mg/dl in the treated-group. Lp(a)-levels were reduced by 4.1mg/dl in the treated and by 2.7mg/dl in the untreated-group. Both groups showed an initial-mean-life-satisfaction below average (-0.9 and -1.2). Within one year after surgery mean-health-status improved in both groups. The difference in health-status after 1-year compared to the health-status of the previous year was statistically different between both groups with a greater benefit in the treated-group. Finally there was a trend detectably pointing towards an improvement in pituitary-function (LH- and FSH-recovery) if GH was substituted.CONCLUSION: Early GH-substitution leads to a significant improvement in quality-of-life and body-composition after pituitary-surgery. It is possible that pituitary-function recovers more with early-GH-substitution.

U2 - 10.1016/j.ghir.2014.03.001

DO - 10.1016/j.ghir.2014.03.001

M3 - SCORING: Journal article

C2 - 24726277

VL - 24

SP - 71

EP - 75

JO - GROWTH HORM IGF RES

JF - GROWTH HORM IGF RES

SN - 1096-6374

IS - 2-3

ER -