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Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload

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Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload. / Sado, Daniel M; Maestrini, Viviana; Piechnik, Stefan K; Banypersad, Sanjay M; White, Steven K; Flett, Andrew S; Robson, Matthew D; Neubauer, Stefan; Ariti, Cono; Arai, Andrew; Kellman, Peter; Yamamura, Jin; Schoennagel, Bjoern P; Shah, Farrukh; Davis, Bernard; Trompeter, Sara; Walker, Malcolm; Porter, John; Moon, James C.

In: J MAGN RESON IMAGING, Vol. 41, No. 6, 06.2015, p. 1505-11.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sado, DM, Maestrini, V, Piechnik, SK, Banypersad, SM, White, SK, Flett, AS, Robson, MD, Neubauer, S, Ariti, C, Arai, A, Kellman, P, Yamamura, J, Schoennagel, BP, Shah, F, Davis, B, Trompeter, S, Walker, M, Porter, J & Moon, JC 2015, 'Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload', J MAGN RESON IMAGING, vol. 41, no. 6, pp. 1505-11. https://doi.org/10.1002/jmri.24727

APA

Sado, D. M., Maestrini, V., Piechnik, S. K., Banypersad, S. M., White, S. K., Flett, A. S., Robson, M. D., Neubauer, S., Ariti, C., Arai, A., Kellman, P., Yamamura, J., Schoennagel, B. P., Shah, F., Davis, B., Trompeter, S., Walker, M., Porter, J., & Moon, J. C. (2015). Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload. J MAGN RESON IMAGING, 41(6), 1505-11. https://doi.org/10.1002/jmri.24727

Vancouver

Sado DM, Maestrini V, Piechnik SK, Banypersad SM, White SK, Flett AS et al. Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload. J MAGN RESON IMAGING. 2015 Jun;41(6):1505-11. https://doi.org/10.1002/jmri.24727

Bibtex

@article{fcad0922379a46d29dbb6c615f1e6084,
title = "Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload",
abstract = "PURPOSE: To explore the use and reproducibility of magnetic resonance-derived myocardial T1 mapping in patients with iron overload.MATERIALS AND METHODS: The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty-five patients underwent repeat scanning for reproducibility. T1 mapping used the shortened modified Look-Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. T2 * was performed using a commercially available sequence. The analysis of the T2 * interstudy reproducibility data was performed by two different research groups using two different methods.RESULTS: Myocardial T1 was lower in patients than healthy volunteers (836 ± 138 msec vs. 968 ± 32 msec, P < 0.0001). Myocardial T1 correlated with T2 * (R = 0.79, P < 0.0001). No patient with low T2 * had normal T1 , but 32% (n = 28) of cases characterized by a normal T2 * had low myocardial T1 . Interstudy reproducibility of either T1 sequence was significantly better than T2 *, with the results suggesting that the use of T1 in clinical trials could decrease potential sample sizes by 7-fold.CONCLUSION: Myocardial T1 mapping is an alternative method for cardiac iron quantification. T1 mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of T1 has potential implications for clinical trial design and therapeutic monitoring.",
author = "Sado, {Daniel M} and Viviana Maestrini and Piechnik, {Stefan K} and Banypersad, {Sanjay M} and White, {Steven K} and Flett, {Andrew S} and Robson, {Matthew D} and Stefan Neubauer and Cono Ariti and Andrew Arai and Peter Kellman and Jin Yamamura and Schoennagel, {Bjoern P} and Farrukh Shah and Bernard Davis and Sara Trompeter and Malcolm Walker and John Porter and Moon, {James C}",
note = "{\textcopyright} 2014 Wiley Periodicals, Inc.",
year = "2015",
month = jun,
doi = "10.1002/jmri.24727",
language = "English",
volume = "41",
pages = "1505--11",
journal = "J MAGN RESON IMAGING",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload

AU - Sado, Daniel M

AU - Maestrini, Viviana

AU - Piechnik, Stefan K

AU - Banypersad, Sanjay M

AU - White, Steven K

AU - Flett, Andrew S

AU - Robson, Matthew D

AU - Neubauer, Stefan

AU - Ariti, Cono

AU - Arai, Andrew

AU - Kellman, Peter

AU - Yamamura, Jin

AU - Schoennagel, Bjoern P

AU - Shah, Farrukh

AU - Davis, Bernard

AU - Trompeter, Sara

AU - Walker, Malcolm

AU - Porter, John

AU - Moon, James C

N1 - © 2014 Wiley Periodicals, Inc.

PY - 2015/6

Y1 - 2015/6

N2 - PURPOSE: To explore the use and reproducibility of magnetic resonance-derived myocardial T1 mapping in patients with iron overload.MATERIALS AND METHODS: The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty-five patients underwent repeat scanning for reproducibility. T1 mapping used the shortened modified Look-Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. T2 * was performed using a commercially available sequence. The analysis of the T2 * interstudy reproducibility data was performed by two different research groups using two different methods.RESULTS: Myocardial T1 was lower in patients than healthy volunteers (836 ± 138 msec vs. 968 ± 32 msec, P < 0.0001). Myocardial T1 correlated with T2 * (R = 0.79, P < 0.0001). No patient with low T2 * had normal T1 , but 32% (n = 28) of cases characterized by a normal T2 * had low myocardial T1 . Interstudy reproducibility of either T1 sequence was significantly better than T2 *, with the results suggesting that the use of T1 in clinical trials could decrease potential sample sizes by 7-fold.CONCLUSION: Myocardial T1 mapping is an alternative method for cardiac iron quantification. T1 mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of T1 has potential implications for clinical trial design and therapeutic monitoring.

AB - PURPOSE: To explore the use and reproducibility of magnetic resonance-derived myocardial T1 mapping in patients with iron overload.MATERIALS AND METHODS: The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty-five patients underwent repeat scanning for reproducibility. T1 mapping used the shortened modified Look-Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. T2 * was performed using a commercially available sequence. The analysis of the T2 * interstudy reproducibility data was performed by two different research groups using two different methods.RESULTS: Myocardial T1 was lower in patients than healthy volunteers (836 ± 138 msec vs. 968 ± 32 msec, P < 0.0001). Myocardial T1 correlated with T2 * (R = 0.79, P < 0.0001). No patient with low T2 * had normal T1 , but 32% (n = 28) of cases characterized by a normal T2 * had low myocardial T1 . Interstudy reproducibility of either T1 sequence was significantly better than T2 *, with the results suggesting that the use of T1 in clinical trials could decrease potential sample sizes by 7-fold.CONCLUSION: Myocardial T1 mapping is an alternative method for cardiac iron quantification. T1 mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of T1 has potential implications for clinical trial design and therapeutic monitoring.

U2 - 10.1002/jmri.24727

DO - 10.1002/jmri.24727

M3 - SCORING: Journal article

C2 - 25104503

VL - 41

SP - 1505

EP - 1511

JO - J MAGN RESON IMAGING

JF - J MAGN RESON IMAGING

SN - 1053-1807

IS - 6

ER -