Research ExplorerPublicationsNomograms predicting Overall Survival and Cancer-specific Su...

Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis

Standard

Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis. / Li, Yuqiang; Liu, Wenxue; Zhao, Lilan; Güngör, Cenap; Xu, Yang; Song, Xiangping; Wang, Dan; Zhou, Zhongyi; Zhou, Yuan; Li, Chenglong; Pei, Qian; Tan, Fengbo; Pei, Haiping.

In: J CANCER, Vol. 11, No. 21, 2020, p. 6213-6225.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Li, Y, Liu, W, Zhao, L, Güngör, C, Xu, Y, Song, X, Wang, D, Zhou, Z, Zhou, Y, Li, C, Pei, Q, Tan, F & Pei, H 2020, 'Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis', J CANCER, vol. 11, no. 21, pp. 6213-6225. https://doi.org/10.7150/jca.46155

APA

Li, Y., Liu, W., Zhao, L., Güngör, C., Xu, Y., Song, X., Wang, D., Zhou, Z., Zhou, Y., Li, C., Pei, Q., Tan, F., & Pei, H. (2020). Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis. J CANCER, 11(21), 6213-6225. https://doi.org/10.7150/jca.46155

Vancouver

Li Y, Liu W, Zhao L, Güngör C, Xu Y, Song X et al. Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis. J CANCER. 2020;11(21):6213-6225. https://doi.org/10.7150/jca.46155

Bibtex

@article{c41fb33396af4304b8f4a715433e6c84,
title = "Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis",
abstract = "Background: Colorectal cancer (CRC) ranks as the third most frequent cancer type and the second leading cause of cancer-related death worldwide. The liver is the most common metastatic site of CRC with 20%-34% of patients suffering synchronous liver metastasis. Patients with colorectal liver-limited metastasis account for one-third of deaths from colorectal cancer. Moreover, some evidence indicated that CRC patients with synchronous liver disease encounter a worse prognosis and more disseminated disease state comparing with metastatic liver disease that develops metachronously. Methods: Data in this retrospective analysis were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms were constructed with basis from a multivariate Cox regression analysis. The prognostic nomograms were validated by C-index, time-dependent receiver operating characteristic (ROC) curve, decision curve analysis (DCA) and calibration curves. Results: A total of 9,958 CRC patients with synchronous liver-limited metastasis were extracted from the SEER database during 2010-2016. Both overall survival (OS) and cancer-specific survival (CSS) were significantly correlated with age, marital status, race, tumor location, pathological grade, histologic type, T stage, N stage, surgery for primary tumor, surgery for liver metastasis, chemotherapy and CEA. All of the significant variables were used to create the nomograms predicting OS and CSS. C-index values, time-dependent ROC curves, DCA curves and calibration curves, proved the superiority of the nomograms. Conclusions: Our research investigated a national cohort of almost 10,000 patients to create and verify nomograms based on pathological, therapeutic and demographic features to predict OS and CSS for synchronous colorectal liver-limited metastasis (SCLLM). The nomograms may act as an excellent tool to integrate clinical characteristics to guide the therapeutic choice for SCLLM patients.",
author = "Yuqiang Li and Wenxue Liu and Lilan Zhao and Cenap G{\"u}ng{\"o}r and Yang Xu and Xiangping Song and Dan Wang and Zhongyi Zhou and Yuan Zhou and Chenglong Li and Qian Pei and Fengbo Tan and Haiping Pei",
note = "{\textcopyright} The author(s).",
year = "2020",
doi = "10.7150/jca.46155",
language = "English",
volume = "11",
pages = "6213--6225",
journal = "J CANCER",
issn = "1837-9664",
publisher = "IVYSPRING INT PUBL ",
number = "21",

}

RIS

TY - JOUR

T1 - Nomograms predicting Overall Survival and Cancer-specific Survival for Synchronous Colorectal Liver-limited Metastasis

AU - Li, Yuqiang

AU - Liu, Wenxue

AU - Zhao, Lilan

AU - Güngör, Cenap

AU - Xu, Yang

AU - Song, Xiangping

AU - Wang, Dan

AU - Zhou, Zhongyi

AU - Zhou, Yuan

AU - Li, Chenglong

AU - Pei, Qian

AU - Tan, Fengbo

AU - Pei, Haiping

N1 - © The author(s).

PY - 2020

Y1 - 2020

N2 - Background: Colorectal cancer (CRC) ranks as the third most frequent cancer type and the second leading cause of cancer-related death worldwide. The liver is the most common metastatic site of CRC with 20%-34% of patients suffering synchronous liver metastasis. Patients with colorectal liver-limited metastasis account for one-third of deaths from colorectal cancer. Moreover, some evidence indicated that CRC patients with synchronous liver disease encounter a worse prognosis and more disseminated disease state comparing with metastatic liver disease that develops metachronously. Methods: Data in this retrospective analysis were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms were constructed with basis from a multivariate Cox regression analysis. The prognostic nomograms were validated by C-index, time-dependent receiver operating characteristic (ROC) curve, decision curve analysis (DCA) and calibration curves. Results: A total of 9,958 CRC patients with synchronous liver-limited metastasis were extracted from the SEER database during 2010-2016. Both overall survival (OS) and cancer-specific survival (CSS) were significantly correlated with age, marital status, race, tumor location, pathological grade, histologic type, T stage, N stage, surgery for primary tumor, surgery for liver metastasis, chemotherapy and CEA. All of the significant variables were used to create the nomograms predicting OS and CSS. C-index values, time-dependent ROC curves, DCA curves and calibration curves, proved the superiority of the nomograms. Conclusions: Our research investigated a national cohort of almost 10,000 patients to create and verify nomograms based on pathological, therapeutic and demographic features to predict OS and CSS for synchronous colorectal liver-limited metastasis (SCLLM). The nomograms may act as an excellent tool to integrate clinical characteristics to guide the therapeutic choice for SCLLM patients.

AB - Background: Colorectal cancer (CRC) ranks as the third most frequent cancer type and the second leading cause of cancer-related death worldwide. The liver is the most common metastatic site of CRC with 20%-34% of patients suffering synchronous liver metastasis. Patients with colorectal liver-limited metastasis account for one-third of deaths from colorectal cancer. Moreover, some evidence indicated that CRC patients with synchronous liver disease encounter a worse prognosis and more disseminated disease state comparing with metastatic liver disease that develops metachronously. Methods: Data in this retrospective analysis were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms were constructed with basis from a multivariate Cox regression analysis. The prognostic nomograms were validated by C-index, time-dependent receiver operating characteristic (ROC) curve, decision curve analysis (DCA) and calibration curves. Results: A total of 9,958 CRC patients with synchronous liver-limited metastasis were extracted from the SEER database during 2010-2016. Both overall survival (OS) and cancer-specific survival (CSS) were significantly correlated with age, marital status, race, tumor location, pathological grade, histologic type, T stage, N stage, surgery for primary tumor, surgery for liver metastasis, chemotherapy and CEA. All of the significant variables were used to create the nomograms predicting OS and CSS. C-index values, time-dependent ROC curves, DCA curves and calibration curves, proved the superiority of the nomograms. Conclusions: Our research investigated a national cohort of almost 10,000 patients to create and verify nomograms based on pathological, therapeutic and demographic features to predict OS and CSS for synchronous colorectal liver-limited metastasis (SCLLM). The nomograms may act as an excellent tool to integrate clinical characteristics to guide the therapeutic choice for SCLLM patients.

U2 - 10.7150/jca.46155

DO - 10.7150/jca.46155

M3 - SCORING: Journal article

C2 - 33033504

VL - 11

SP - 6213

EP - 6225

JO - J CANCER

JF - J CANCER

SN - 1837-9664

IS - 21

ER -