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No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

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No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. / Khan, Wasim; Giampietro, Vincent; Ginestet, Cedric; Dell'Acqua, Flavio; Bouls, David; Newhouse, Steven; Dobson, Richard; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Conrod, Patricia; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Anreas; Ittermann, Bernd; Lemaître, Hervé; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Smolka, Michael N; Ströhle, Andreas; Gallinat, Jean; Westman, Eric; Schumann, Gunther; Lovestone, Simon; Simmons, Andrew; IMAGEN Consortium.

In: J ALZHEIMERS DIS, Vol. 40, No. 1, 2014, p. 37-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Khan, W, Giampietro, V, Ginestet, C, Dell'Acqua, F, Bouls, D, Newhouse, S, Dobson, R, Banaschewski, T, Barker, GJ, Bokde, ALW, Büchel, C, Conrod, P, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lemaître, H, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Smolka, MN, Ströhle, A, Gallinat, J, Westman, E, Schumann, G, Lovestone, S, Simmons, A & IMAGEN Consortium 2014, 'No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents', J ALZHEIMERS DIS, vol. 40, no. 1, pp. 37-43. https://doi.org/10.3233/JAD-131841

APA

Khan, W., Giampietro, V., Ginestet, C., Dell'Acqua, F., Bouls, D., Newhouse, S., Dobson, R., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaître, H., ... IMAGEN Consortium (2014). No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. J ALZHEIMERS DIS, 40(1), 37-43. https://doi.org/10.3233/JAD-131841

Vancouver

Khan W, Giampietro V, Ginestet C, Dell'Acqua F, Bouls D, Newhouse S et al. No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. J ALZHEIMERS DIS. 2014;40(1):37-43. https://doi.org/10.3233/JAD-131841

Bibtex

@article{02b07e1abc9e4eb7b5d22768fc9dc629,
title = "No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents",
abstract = "Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.",
author = "Wasim Khan and Vincent Giampietro and Cedric Ginestet and Flavio Dell'Acqua and David Bouls and Steven Newhouse and Richard Dobson and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Christian B{\"u}chel and Patricia Conrod and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Anreas Heinz and Bernd Ittermann and Herv{\'e} Lema{\^i}tre and Frauke Nees and Tomas Paus and Zdenka Pausova and Marcella Rietschel and Smolka, {Michael N} and Andreas Str{\"o}hle and Jean Gallinat and Eric Westman and Gunther Schumann and Simon Lovestone and Andrew Simmons and {IMAGEN Consortium}",
year = "2014",
doi = "10.3233/JAD-131841",
language = "English",
volume = "40",
pages = "37--43",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "1",

}

RIS

TY - JOUR

T1 - No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

AU - Khan, Wasim

AU - Giampietro, Vincent

AU - Ginestet, Cedric

AU - Dell'Acqua, Flavio

AU - Bouls, David

AU - Newhouse, Steven

AU - Dobson, Richard

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Anreas

AU - Ittermann, Bernd

AU - Lemaître, Hervé

AU - Nees, Frauke

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Gallinat, Jean

AU - Westman, Eric

AU - Schumann, Gunther

AU - Lovestone, Simon

AU - Simmons, Andrew

AU - IMAGEN Consortium

PY - 2014

Y1 - 2014

N2 - Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.

AB - Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.

U2 - 10.3233/JAD-131841

DO - 10.3233/JAD-131841

M3 - SCORING: Journal article

C2 - 24326516

VL - 40

SP - 37

EP - 43

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 1

ER -