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No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study

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No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study. / Dong, Jing; Gharahkhani, Puya; Chow, Wong-Ho; Gammon, Marilie D; Liu, Geoffrey; Caldas, Carlos; Wu, Anna H; Ye, Weimin; Onstad, Lynn; Anderson, Lesley A; Bernstein, Leslie; Pharoah, Paul D; Risch, Harvey A; Corley, Douglas A; Fitzgerald, Rebecca C; Iyer, Prasad G; Reid, Brian J; Lagergren, Jesper; Shaheen, Nicholas J; Vaughan, Thomas L; MacGregor, Stuart; Love, Sharon; Palles, Claire; Tomlinson, Ian; Gockel, Ines; May, Andrea; Gerges, Christian; Anders, Mario; Böhmer, Anne C; Becker, Jessica; Kreuser, Nicole; Thieme, Rene; Noder, Tania; Venerito, Marino; Veits, Lothar; Schmidt, Thomas; Schmidt, Claudia; Izbicki, Jakob R; Hölscher, Arnulf H; Lang, Hauke; Lorenz, Dietmar; Schumacher, Brigitte; Mayershofer, Rupert; Vashist, Yogesh; Ott, Katja; Vieth, Michael; Weismüller, Josef; Nöthen, Markus M; Moebus, Susanne; Knapp, Michael; Peters, Wilbert H M; Neuhaus, Horst; Rösch, Thomas; Ell, Christian; Jankowski, Janusz; Schumacher, Johannes; Neale, Rachel E; Whiteman, David C; Thrift, Aaron P; Stomach and Oesophageal Cancer Study (SOCS) consortium.

In: CLIN GASTROENTEROL H, Vol. 17, No. 11, 10.2019, p. 2227-2235.e1.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dong, J, Gharahkhani, P, Chow, W-H, Gammon, MD, Liu, G, Caldas, C, Wu, AH, Ye, W, Onstad, L, Anderson, LA, Bernstein, L, Pharoah, PD, Risch, HA, Corley, DA, Fitzgerald, RC, Iyer, PG, Reid, BJ, Lagergren, J, Shaheen, NJ, Vaughan, TL, MacGregor, S, Love, S, Palles, C, Tomlinson, I, Gockel, I, May, A, Gerges, C, Anders, M, Böhmer, AC, Becker, J, Kreuser, N, Thieme, R, Noder, T, Venerito, M, Veits, L, Schmidt, T, Schmidt, C, Izbicki, JR, Hölscher, AH, Lang, H, Lorenz, D, Schumacher, B, Mayershofer, R, Vashist, Y, Ott, K, Vieth, M, Weismüller, J, Nöthen, MM, Moebus, S, Knapp, M, Peters, WHM, Neuhaus, H, Rösch, T, Ell, C, Jankowski, J, Schumacher, J, Neale, RE, Whiteman, DC, Thrift, AP & Stomach and Oesophageal Cancer Study (SOCS) consortium 2019, 'No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study', CLIN GASTROENTEROL H, vol. 17, no. 11, pp. 2227-2235.e1. https://doi.org/10.1016/j.cgh.2019.01.041

APA

Dong, J., Gharahkhani, P., Chow, W-H., Gammon, M. D., Liu, G., Caldas, C., Wu, A. H., Ye, W., Onstad, L., Anderson, L. A., Bernstein, L., Pharoah, P. D., Risch, H. A., Corley, D. A., Fitzgerald, R. C., Iyer, P. G., Reid, B. J., Lagergren, J., Shaheen, N. J., ... Stomach and Oesophageal Cancer Study (SOCS) consortium (2019). No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study. CLIN GASTROENTEROL H, 17(11), 2227-2235.e1. https://doi.org/10.1016/j.cgh.2019.01.041

Vancouver

Dong J, Gharahkhani P, Chow W-H, Gammon MD, Liu G, Caldas C et al. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study. CLIN GASTROENTEROL H. 2019 Oct;17(11):2227-2235.e1. https://doi.org/10.1016/j.cgh.2019.01.041

Bibtex

@article{43e61cc8a1df4bb3813a080be73c90c1,
title = "No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study",
abstract = "BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC.RESULTS: Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18).CONCLUSIONS: In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.",
keywords = "Journal Article",
author = "Jing Dong and Puya Gharahkhani and Wong-Ho Chow and Gammon, {Marilie D} and Geoffrey Liu and Carlos Caldas and Wu, {Anna H} and Weimin Ye and Lynn Onstad and Anderson, {Lesley A} and Leslie Bernstein and Pharoah, {Paul D} and Risch, {Harvey A} and Corley, {Douglas A} and Fitzgerald, {Rebecca C} and Iyer, {Prasad G} and Reid, {Brian J} and Jesper Lagergren and Shaheen, {Nicholas J} and Vaughan, {Thomas L} and Stuart MacGregor and Sharon Love and Claire Palles and Ian Tomlinson and Ines Gockel and Andrea May and Christian Gerges and Mario Anders and B{\"o}hmer, {Anne C} and Jessica Becker and Nicole Kreuser and Rene Thieme and Tania Noder and Marino Venerito and Lothar Veits and Thomas Schmidt and Claudia Schmidt and Izbicki, {Jakob R} and H{\"o}lscher, {Arnulf H} and Hauke Lang and Dietmar Lorenz and Brigitte Schumacher and Rupert Mayershofer and Yogesh Vashist and Katja Ott and Michael Vieth and Josef Weism{\"u}ller and N{\"o}then, {Markus M} and Susanne Moebus and Michael Knapp and Peters, {Wilbert H M} and Horst Neuhaus and Thomas R{\"o}sch and Christian Ell and Janusz Jankowski and Johannes Schumacher and Neale, {Rachel E} and Whiteman, {David C} and Thrift, {Aaron P} and {Stomach and Oesophageal Cancer Study (SOCS) consortium}",
note = "Copyright {\textcopyright} 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = oct,
doi = "10.1016/j.cgh.2019.01.041",
language = "English",
volume = "17",
pages = "2227--2235.e1",
journal = "CLIN GASTROENTEROL H",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study

AU - Dong, Jing

AU - Gharahkhani, Puya

AU - Chow, Wong-Ho

AU - Gammon, Marilie D

AU - Liu, Geoffrey

AU - Caldas, Carlos

AU - Wu, Anna H

AU - Ye, Weimin

AU - Onstad, Lynn

AU - Anderson, Lesley A

AU - Bernstein, Leslie

AU - Pharoah, Paul D

AU - Risch, Harvey A

AU - Corley, Douglas A

AU - Fitzgerald, Rebecca C

AU - Iyer, Prasad G

AU - Reid, Brian J

AU - Lagergren, Jesper

AU - Shaheen, Nicholas J

AU - Vaughan, Thomas L

AU - MacGregor, Stuart

AU - Love, Sharon

AU - Palles, Claire

AU - Tomlinson, Ian

AU - Gockel, Ines

AU - May, Andrea

AU - Gerges, Christian

AU - Anders, Mario

AU - Böhmer, Anne C

AU - Becker, Jessica

AU - Kreuser, Nicole

AU - Thieme, Rene

AU - Noder, Tania

AU - Venerito, Marino

AU - Veits, Lothar

AU - Schmidt, Thomas

AU - Schmidt, Claudia

AU - Izbicki, Jakob R

AU - Hölscher, Arnulf H

AU - Lang, Hauke

AU - Lorenz, Dietmar

AU - Schumacher, Brigitte

AU - Mayershofer, Rupert

AU - Vashist, Yogesh

AU - Ott, Katja

AU - Vieth, Michael

AU - Weismüller, Josef

AU - Nöthen, Markus M

AU - Moebus, Susanne

AU - Knapp, Michael

AU - Peters, Wilbert H M

AU - Neuhaus, Horst

AU - Rösch, Thomas

AU - Ell, Christian

AU - Jankowski, Janusz

AU - Schumacher, Johannes

AU - Neale, Rachel E

AU - Whiteman, David C

AU - Thrift, Aaron P

AU - Stomach and Oesophageal Cancer Study (SOCS) consortium

N1 - Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC.RESULTS: Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18).CONCLUSIONS: In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.

AB - BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC.RESULTS: Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18).CONCLUSIONS: In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.

KW - Journal Article

U2 - 10.1016/j.cgh.2019.01.041

DO - 10.1016/j.cgh.2019.01.041

M3 - SCORING: Journal article

C2 - 30716477

VL - 17

SP - 2227-2235.e1

JO - CLIN GASTROENTEROL H

JF - CLIN GASTROENTEROL H

SN - 1542-3565

IS - 11

ER -