Nitroalkylation--a redox sensitive signaling pathway
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Nitroalkylation--a redox sensitive signaling pathway. / Geisler, Anne C; Rudolph, Tanja K.
In: Biochim Biophys Acta, Vol. 1820, No. 6, 06.2012, p. 777-784.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Nitroalkylation--a redox sensitive signaling pathway
AU - Geisler, Anne C
AU - Rudolph, Tanja K
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2012/6
Y1 - 2012/6
N2 - Redox-sensitive posttranslational modification emerged as important signaling mechanisms. Besides other posttranslational modifications nitroalkylation by nitrated fatty acids mediate favorable anti-inflammatory effects. This review gives an overview of the generation and the reactivity of nitrated fatty acids. Additionally, it provides insights into the so far described pathways regulated by nitrated fatty acids. This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation.
AB - Redox-sensitive posttranslational modification emerged as important signaling mechanisms. Besides other posttranslational modifications nitroalkylation by nitrated fatty acids mediate favorable anti-inflammatory effects. This review gives an overview of the generation and the reactivity of nitrated fatty acids. Additionally, it provides insights into the so far described pathways regulated by nitrated fatty acids. This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation.
KW - Alkylation
KW - Animals
KW - Fatty Acids/metabolism
KW - Heme Oxygenase-1/metabolism
KW - Humans
KW - Matrix Metalloproteinases/genetics
KW - NF-E2-Related Factor 2/metabolism
KW - NF-kappa B/metabolism
KW - Nitrates/metabolism
KW - Nitric Oxide/chemistry
KW - Nitrosation/physiology
KW - Oxidation-Reduction
KW - PPAR gamma/metabolism
KW - Protein Processing, Post-Translational
KW - STAT1 Transcription Factor/antagonists & inhibitors
KW - Signal Transduction
U2 - 10.1016/j.bbagen.2011.06.014
DO - 10.1016/j.bbagen.2011.06.014
M3 - SCORING: Review article
C2 - 21723375
VL - 1820
SP - 777
EP - 784
JO - Biochim Biophys Acta
JF - Biochim Biophys Acta
SN - 0006-3002
IS - 6
ER -