Nierenzysten und zystische Nierenerkrankungen bei Kindern (AWMF S2k-Leitlinie)
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Nierenzysten und zystische Nierenerkrankungen bei Kindern (AWMF S2k-Leitlinie). / Gimpel, Charlotte; Bergmann, Carsten; Brinkert, Florian; Cetiner, Metin; Gembruch, Ulrich; Haffner, Dieter; Kemper, Markus; König, Jens; Liebau, Max; Maier, Rolf Felix; Oh, Jun; Pape, Lars; Riechardt, Silke; Rolle, Udo; Rossi, Rainer; Stegmann, Joachim; Vester, Udo; Kaisenberg, Constantin von; Weber, Stefanie; Schaefer, Franz.
In: KLIN PADIATR, Vol. 232, No. 5, 09.2020, p. 228-248.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Nierenzysten und zystische Nierenerkrankungen bei Kindern (AWMF S2k-Leitlinie)
AU - Gimpel, Charlotte
AU - Bergmann, Carsten
AU - Brinkert, Florian
AU - Cetiner, Metin
AU - Gembruch, Ulrich
AU - Haffner, Dieter
AU - Kemper, Markus
AU - König, Jens
AU - Liebau, Max
AU - Maier, Rolf Felix
AU - Oh, Jun
AU - Pape, Lars
AU - Riechardt, Silke
AU - Rolle, Udo
AU - Rossi, Rainer
AU - Stegmann, Joachim
AU - Vester, Udo
AU - Kaisenberg, Constantin von
AU - Weber, Stefanie
AU - Schaefer, Franz
N1 - Thieme. All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - This consensus-based guideline was developed by all relevant German pediatric medical societies. Ultrasound is the standard imaging modality for pre- and postnatal kidney cysts and should also exclude extrarenal manifestations in the abdomen and internal genital organs. MRI has selected indications. Suspicion of a cystic kidney disease should prompt consultation of a pediatric nephrologist. Prenatal management must be tailored to very different degrees of disease severity. After renal oligohydramnios, we recommend delivery in a perinatal center. Neonates should not be denied renal replacement therapy solely because of their age. Children with unilateral multicystic dysplastic kidney do not require routine further imaging or nephrectomy, but long-term nephrology follow-up (as do children with uni- or bilateral kidney hypo-/dysplasia with cysts). ARPKD (autosomal recessive polycystic kidney disease), nephronophthisis, Bardet-Biedl syndrome and HNF1B mutations cause relevant extrarenal disease and genetic testing is advisable. Children with tuberous sclerosis complex, tumor predisposition (e. g. von Hippel Lindau syndrome) or high risk of acquired kidney cysts should have regular ultrasounds. Even asymptomatic children of parents with ADPKD (autosomal dominant PKD) should be monitored for hypertension and proteinuria. Presymptomatic diagnostic ultrasound or genetic examination for ADPKD in minors should only be done after thorough counselling. Simple cysts are very rare in children and ADPKD in a parent should be excluded. Complex renal cysts require further investigation.
AB - This consensus-based guideline was developed by all relevant German pediatric medical societies. Ultrasound is the standard imaging modality for pre- and postnatal kidney cysts and should also exclude extrarenal manifestations in the abdomen and internal genital organs. MRI has selected indications. Suspicion of a cystic kidney disease should prompt consultation of a pediatric nephrologist. Prenatal management must be tailored to very different degrees of disease severity. After renal oligohydramnios, we recommend delivery in a perinatal center. Neonates should not be denied renal replacement therapy solely because of their age. Children with unilateral multicystic dysplastic kidney do not require routine further imaging or nephrectomy, but long-term nephrology follow-up (as do children with uni- or bilateral kidney hypo-/dysplasia with cysts). ARPKD (autosomal recessive polycystic kidney disease), nephronophthisis, Bardet-Biedl syndrome and HNF1B mutations cause relevant extrarenal disease and genetic testing is advisable. Children with tuberous sclerosis complex, tumor predisposition (e. g. von Hippel Lindau syndrome) or high risk of acquired kidney cysts should have regular ultrasounds. Even asymptomatic children of parents with ADPKD (autosomal dominant PKD) should be monitored for hypertension and proteinuria. Presymptomatic diagnostic ultrasound or genetic examination for ADPKD in minors should only be done after thorough counselling. Simple cysts are very rare in children and ADPKD in a parent should be excluded. Complex renal cysts require further investigation.
KW - Child
KW - Cysts/pathology
KW - Female
KW - Humans
KW - Infant, Newborn
KW - Kidney Neoplasms/pathology
KW - Male
KW - Polycystic Kidney, Autosomal Dominant/diagnosis
KW - Polycystic Kidney, Autosomal Recessive/diagnosis
KW - Practice Guidelines as Topic
KW - Pregnancy
KW - Societies, Medical
U2 - 10.1055/a-1179-0728
DO - 10.1055/a-1179-0728
M3 - SCORING: Zeitschriftenaufsatz
C2 - 32659844
VL - 232
SP - 228
EP - 248
JO - KLIN PADIATR
JF - KLIN PADIATR
SN - 0300-8630
IS - 5
ER -
