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Next-Generation optical imaging with short-wave infrared quantum dots

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Next-Generation optical imaging with short-wave infrared quantum dots. / Bruns, Oliver T; Bischof, Thomas S; Harris, Daniel K; Franke, Daniel; Shi, Yanxiang; Riedemann, Lars; Bartelt, Alexander; Jaworski, Frank B; Carr, Jessica A; Rowlands, Christopher J; Wilson, Mark W B; Chen, Ou; Wei, He; Hwang, Gyu Weon; Montana, Daniel M; Coropceanu, Igor; Achorn, Odin B; Kloepper, Jonas; Heeren, Joerg; So, Peter T C; Fukumura, Dai; Jensen, Klavs F; Jain, Rakesh K; Bawendi, Moungi G.

In: NAT BIOMED ENG, Vol. 1, No. 4, 2017, p. UNSP 0056.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bruns, OT, Bischof, TS, Harris, DK, Franke, D, Shi, Y, Riedemann, L, Bartelt, A, Jaworski, FB, Carr, JA, Rowlands, CJ, Wilson, MWB, Chen, O, Wei, H, Hwang, GW, Montana, DM, Coropceanu, I, Achorn, OB, Kloepper, J, Heeren, J, So, PTC, Fukumura, D, Jensen, KF, Jain, RK & Bawendi, MG 2017, 'Next-Generation optical imaging with short-wave infrared quantum dots', NAT BIOMED ENG, vol. 1, no. 4, pp. UNSP 0056. https://doi.org/10.1038/s41551-017-0056

APA

Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., Wilson, M. W. B., Chen, O., Wei, H., Hwang, G. W., Montana, D. M., Coropceanu, I., Achorn, O. B., Kloepper, J., Heeren, J., ... Bawendi, M. G. (2017). Next-Generation optical imaging with short-wave infrared quantum dots. NAT BIOMED ENG, 1(4), UNSP 0056. https://doi.org/10.1038/s41551-017-0056

Vancouver

Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L et al. Next-Generation optical imaging with short-wave infrared quantum dots. NAT BIOMED ENG. 2017;1(4):UNSP 0056. https://doi.org/10.1038/s41551-017-0056

Bibtex

@article{aae848a5476b414199d422a2ab5cc8d1,
title = "Next-Generation optical imaging with short-wave infrared quantum dots",
abstract = "Forin vivoimaging, the short-wavelength infrared region (SWIR; 1000-2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.",
keywords = "Journal Article",
author = "Bruns, {Oliver T} and Bischof, {Thomas S} and Harris, {Daniel K} and Daniel Franke and Yanxiang Shi and Lars Riedemann and Alexander Bartelt and Jaworski, {Frank B} and Carr, {Jessica A} and Rowlands, {Christopher J} and Wilson, {Mark W B} and Ou Chen and He Wei and Hwang, {Gyu Weon} and Montana, {Daniel M} and Igor Coropceanu and Achorn, {Odin B} and Jonas Kloepper and Joerg Heeren and So, {Peter T C} and Dai Fukumura and Jensen, {Klavs F} and Jain, {Rakesh K} and Bawendi, {Moungi G}",
year = "2017",
doi = "10.1038/s41551-017-0056",
language = "English",
volume = "1",
pages = "UNSP 0056",
journal = "NAT BIOMED ENG",
issn = "2157-846X",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Next-Generation optical imaging with short-wave infrared quantum dots

AU - Bruns, Oliver T

AU - Bischof, Thomas S

AU - Harris, Daniel K

AU - Franke, Daniel

AU - Shi, Yanxiang

AU - Riedemann, Lars

AU - Bartelt, Alexander

AU - Jaworski, Frank B

AU - Carr, Jessica A

AU - Rowlands, Christopher J

AU - Wilson, Mark W B

AU - Chen, Ou

AU - Wei, He

AU - Hwang, Gyu Weon

AU - Montana, Daniel M

AU - Coropceanu, Igor

AU - Achorn, Odin B

AU - Kloepper, Jonas

AU - Heeren, Joerg

AU - So, Peter T C

AU - Fukumura, Dai

AU - Jensen, Klavs F

AU - Jain, Rakesh K

AU - Bawendi, Moungi G

PY - 2017

Y1 - 2017

N2 - Forin vivoimaging, the short-wavelength infrared region (SWIR; 1000-2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.

AB - Forin vivoimaging, the short-wavelength infrared region (SWIR; 1000-2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.

KW - Journal Article

U2 - 10.1038/s41551-017-0056

DO - 10.1038/s41551-017-0056

M3 - SCORING: Journal article

C2 - 29119058

VL - 1

SP - UNSP 0056

JO - NAT BIOMED ENG

JF - NAT BIOMED ENG

SN - 2157-846X

IS - 4

ER -