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New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis

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New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis. / Heinrich, Fabian; Roedl, Kevin; Jarczak, Dominik; Goebels, Hanna-Lisa; Heinemann, Axel; Schäfer, Ulrich; Ludwig, Frank; Bachmann, Martin; Bein, Berthold; Weber, Christian Friedrich; Sydow, Karsten; Bota, Marc; Paschen, Hans-Richard; Weerth, Andreas de; Veit, Carsten; Detsch, Oliver; Brand, Philipp-Alexander; Kluge, Stefan; Ondruschka, Benjamin; Wichmann, Dominic.

In: VIRUSES-BASEL, Vol. 14, No. 4, 811, 14.04.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heinrich, F, Roedl, K, Jarczak, D, Goebels, H-L, Heinemann, A, Schäfer, U, Ludwig, F, Bachmann, M, Bein, B, Weber, CF, Sydow, K, Bota, M, Paschen, H-R, Weerth, AD, Veit, C, Detsch, O, Brand, P-A, Kluge, S, Ondruschka, B & Wichmann, D 2022, 'New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis', VIRUSES-BASEL, vol. 14, no. 4, 811. https://doi.org/10.3390/v14040811

APA

Heinrich, F., Roedl, K., Jarczak, D., Goebels, H-L., Heinemann, A., Schäfer, U., Ludwig, F., Bachmann, M., Bein, B., Weber, C. F., Sydow, K., Bota, M., Paschen, H-R., Weerth, A. D., Veit, C., Detsch, O., Brand, P-A., Kluge, S., Ondruschka, B., & Wichmann, D. (2022). New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis. VIRUSES-BASEL, 14(4), [811]. https://doi.org/10.3390/v14040811

Vancouver

Heinrich F, Roedl K, Jarczak D, Goebels H-L, Heinemann A, Schäfer U et al. New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis. VIRUSES-BASEL. 2022 Apr 14;14(4). 811. https://doi.org/10.3390/v14040811

Bibtex

@article{ff639019ffb946b29d6269b00753da67,
title = "New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis",
abstract = "Critically ill COVID-19 patients are at high risk for venous thromboembolism (VTE), namely deep vein thrombosis (DVT) and/or pulmonary embolism (PE), and death. The optimal anticoagulation strategy in critically ill patients with COVID-19 remains unknown. This study investigated the ante mortem incidence as well as postmortem prevalence of VTE, the factors predictive of VTE, and the impact of changed anticoagulation practice on patient survival. We conducted a consecutive retrospective analysis of postmortem COVID-19 (n = 64) and non-COVID-19 (n = 67) patients, as well as ante mortem COVID-19 (n = 170) patients admitted to the University Medical Center Hamburg-Eppendorf (Hamburg, Germany). Baseline patient characteristics, parameters related to the intensive care unit (ICU) stay, and the clinical and autoptic presence of VTE were evaluated and statistically compared between groups. The occurrence of VTE in critically ill COVID-19 patients is confirmed in both ante mortem (17%) and postmortem (38%) cohorts. Accordingly, comparing the postmortem prevalence of VTE between age- and sex-matched COVID-19 (43%) and non-COVID-19 (0%) cohorts, we found the statistically significant increased prevalence of VTE in critically ill COVID-19 cohorts (p = 0.001). A change in anticoagulation practice was associated with the statistically significant prolongation of survival time (HR: 2.55, [95% CI 1.41-4.61], p = 0.01) and a reduction in VTE occurrence (54% vs. 25%; p = 0.02). In summary, in the autopsy as well as clinical cohort of critically ill patients with COVID-19, we found that VTE was a frequent finding. A change in anticoagulation practice was associated with a statistically significantly prolonged survival time.",
author = "Fabian Heinrich and Kevin Roedl and Dominik Jarczak and Hanna-Lisa Goebels and Axel Heinemann and Ulrich Sch{\"a}fer and Frank Ludwig and Martin Bachmann and Berthold Bein and Weber, {Christian Friedrich} and Karsten Sydow and Marc Bota and Hans-Richard Paschen and Weerth, {Andreas de} and Carsten Veit and Oliver Detsch and Philipp-Alexander Brand and Stefan Kluge and Benjamin Ondruschka and Dominic Wichmann",
year = "2022",
month = apr,
day = "14",
doi = "10.3390/v14040811",
language = "English",
volume = "14",
journal = "VIRUSES-BASEL",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19 - A Large Postmortem and Clinical Analysis

AU - Heinrich, Fabian

AU - Roedl, Kevin

AU - Jarczak, Dominik

AU - Goebels, Hanna-Lisa

AU - Heinemann, Axel

AU - Schäfer, Ulrich

AU - Ludwig, Frank

AU - Bachmann, Martin

AU - Bein, Berthold

AU - Weber, Christian Friedrich

AU - Sydow, Karsten

AU - Bota, Marc

AU - Paschen, Hans-Richard

AU - Weerth, Andreas de

AU - Veit, Carsten

AU - Detsch, Oliver

AU - Brand, Philipp-Alexander

AU - Kluge, Stefan

AU - Ondruschka, Benjamin

AU - Wichmann, Dominic

PY - 2022/4/14

Y1 - 2022/4/14

N2 - Critically ill COVID-19 patients are at high risk for venous thromboembolism (VTE), namely deep vein thrombosis (DVT) and/or pulmonary embolism (PE), and death. The optimal anticoagulation strategy in critically ill patients with COVID-19 remains unknown. This study investigated the ante mortem incidence as well as postmortem prevalence of VTE, the factors predictive of VTE, and the impact of changed anticoagulation practice on patient survival. We conducted a consecutive retrospective analysis of postmortem COVID-19 (n = 64) and non-COVID-19 (n = 67) patients, as well as ante mortem COVID-19 (n = 170) patients admitted to the University Medical Center Hamburg-Eppendorf (Hamburg, Germany). Baseline patient characteristics, parameters related to the intensive care unit (ICU) stay, and the clinical and autoptic presence of VTE were evaluated and statistically compared between groups. The occurrence of VTE in critically ill COVID-19 patients is confirmed in both ante mortem (17%) and postmortem (38%) cohorts. Accordingly, comparing the postmortem prevalence of VTE between age- and sex-matched COVID-19 (43%) and non-COVID-19 (0%) cohorts, we found the statistically significant increased prevalence of VTE in critically ill COVID-19 cohorts (p = 0.001). A change in anticoagulation practice was associated with the statistically significant prolongation of survival time (HR: 2.55, [95% CI 1.41-4.61], p = 0.01) and a reduction in VTE occurrence (54% vs. 25%; p = 0.02). In summary, in the autopsy as well as clinical cohort of critically ill patients with COVID-19, we found that VTE was a frequent finding. A change in anticoagulation practice was associated with a statistically significantly prolonged survival time.

AB - Critically ill COVID-19 patients are at high risk for venous thromboembolism (VTE), namely deep vein thrombosis (DVT) and/or pulmonary embolism (PE), and death. The optimal anticoagulation strategy in critically ill patients with COVID-19 remains unknown. This study investigated the ante mortem incidence as well as postmortem prevalence of VTE, the factors predictive of VTE, and the impact of changed anticoagulation practice on patient survival. We conducted a consecutive retrospective analysis of postmortem COVID-19 (n = 64) and non-COVID-19 (n = 67) patients, as well as ante mortem COVID-19 (n = 170) patients admitted to the University Medical Center Hamburg-Eppendorf (Hamburg, Germany). Baseline patient characteristics, parameters related to the intensive care unit (ICU) stay, and the clinical and autoptic presence of VTE were evaluated and statistically compared between groups. The occurrence of VTE in critically ill COVID-19 patients is confirmed in both ante mortem (17%) and postmortem (38%) cohorts. Accordingly, comparing the postmortem prevalence of VTE between age- and sex-matched COVID-19 (43%) and non-COVID-19 (0%) cohorts, we found the statistically significant increased prevalence of VTE in critically ill COVID-19 cohorts (p = 0.001). A change in anticoagulation practice was associated with the statistically significant prolongation of survival time (HR: 2.55, [95% CI 1.41-4.61], p = 0.01) and a reduction in VTE occurrence (54% vs. 25%; p = 0.02). In summary, in the autopsy as well as clinical cohort of critically ill patients with COVID-19, we found that VTE was a frequent finding. A change in anticoagulation practice was associated with a statistically significantly prolonged survival time.

UR - https://www.mdpi.com/1999-4915/14/4/811

U2 - 10.3390/v14040811

DO - 10.3390/v14040811

M3 - SCORING: Journal article

VL - 14

JO - VIRUSES-BASEL

JF - VIRUSES-BASEL

SN - 1999-4915

IS - 4

M1 - 811

ER -