New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
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New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689. / Zhuravleva, Olesya I; Antonov, Alexandr S; Trang, Vo Thi Dieu; Pivkin, Mikhail V; Khudyakova, Yuliya V; Denisenko, Vladimir A; Popov, Roman S; Kim, Natalya Y; Yurchenko, Ekaterina A; Gerasimenko, Andrey V; Udovenko, Anatoly A; Amsberg, Gunhild von; Dyshlovoy, Sergey A; Afiyatullov, Shamil S.
In: MAR DRUGS, Vol. 19, No. 1, 32, 12.01.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
AU - Zhuravleva, Olesya I
AU - Antonov, Alexandr S
AU - Trang, Vo Thi Dieu
AU - Pivkin, Mikhail V
AU - Khudyakova, Yuliya V
AU - Denisenko, Vladimir A
AU - Popov, Roman S
AU - Kim, Natalya Y
AU - Yurchenko, Ekaterina A
AU - Gerasimenko, Andrey V
AU - Udovenko, Anatoly A
AU - Amsberg, Gunhild von
AU - Dyshlovoy, Sergey A
AU - Afiyatullov, Shamil S
PY - 2021/1/12
Y1 - 2021/1/12
N2 - Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4-6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30-39%.
AB - Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4-6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30-39%.
U2 - 10.3390/md19010032
DO - 10.3390/md19010032
M3 - SCORING: Journal article
C2 - 33445521
VL - 19
JO - MAR DRUGS
JF - MAR DRUGS
SN - 1660-3397
IS - 1
M1 - 32
ER -