New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696
Standard
New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696. / Zhuravleva, Olesya I; Oleinikova, Galina K; Antonov, Alexandr S; Kirichuk, Natalia N; Pelageev, Dmitry N; Rasin, Anton B; Menshov, Alexander S; Popov, Roman S; Kim, Natalya Yu; Chingizova, Ekaterina A; Chingizov, Artur R; Volchkova, Olga O; von Amsberg, Gunhild; Dyshlovoy, Sergey A; Yurchenko, Ekaterina A; Guzhova, Irina V; Yurchenko, Anton N.
In: J FUNGI, Vol. 8, No. 5, 454, 27.04.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696
AU - Zhuravleva, Olesya I
AU - Oleinikova, Galina K
AU - Antonov, Alexandr S
AU - Kirichuk, Natalia N
AU - Pelageev, Dmitry N
AU - Rasin, Anton B
AU - Menshov, Alexander S
AU - Popov, Roman S
AU - Kim, Natalya Yu
AU - Chingizova, Ekaterina A
AU - Chingizov, Artur R
AU - Volchkova, Olga O
AU - von Amsberg, Gunhild
AU - Dyshlovoy, Sergey A
AU - Yurchenko, Ekaterina A
AU - Guzhova, Irina V
AU - Yurchenko, Anton N
PY - 2022/4/27
Y1 - 2022/4/27
N2 - Six new polyketides acrucipentyns A-F (1-6) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A-F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of Staphylococcus aureus and decreased LDH release from human keratinocytes HaCaT in S. aureus skin infection in an in vitro model.
AB - Six new polyketides acrucipentyns A-F (1-6) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A-F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of Staphylococcus aureus and decreased LDH release from human keratinocytes HaCaT in S. aureus skin infection in an in vitro model.
U2 - 10.3390/jof8050454
DO - 10.3390/jof8050454
M3 - SCORING: Journal article
C2 - 35628710
VL - 8
JO - J FUNGI
JF - J FUNGI
SN - 2309-608X
IS - 5
M1 - 454
ER -